Genotype Distribution and Prevalence of Human Papillomavirus in Head and Neck Cancer Samples from Istanbul, Turkey
Human papillomavirus (HPV)-associated tumors account for a significant proportion of head and neck squamous cell carcinomas (HNSCC) in developed countries. In recent years, there has been a rise of HPV infections associated with HNSCC, especially HPV16, which is the most commonly detected type in or...
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MDPI AG
2021-11-01
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| Online Access: | https://www.mdpi.com/2076-0817/10/12/1533 |
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| author | Muammer Osman Köksal Başak Keskin Yalçın Fahriye Keskin Sevgi Çiftçi Ibrahim Yağcı Seyhan Özakkoyunlu Hasçiçek Bora Başaran Kemal Değer Ali Ağaçfidan Alexander Quaas Baki Akgül |
| author_facet | Muammer Osman Köksal Başak Keskin Yalçın Fahriye Keskin Sevgi Çiftçi Ibrahim Yağcı Seyhan Özakkoyunlu Hasçiçek Bora Başaran Kemal Değer Ali Ağaçfidan Alexander Quaas Baki Akgül |
| author_sort | Muammer Osman Köksal |
| collection | DOAJ |
| description | Human papillomavirus (HPV)-associated tumors account for a significant proportion of head and neck squamous cell carcinomas (HNSCC) in developed countries. In recent years, there has been a rise of HPV infections associated with HNSCC, especially HPV16, which is the most commonly detected type in oral and oropharyngeal cancers. To investigate the frequency of HPV-driven HNSCC among patients living in Turkey, HPV DNA positivity and p16INK4A expression were assessed in primary tumor biopsies (n = 106). Eighteen out of one hundred and six (19%) HNSCC tumors showed p16INK4A overexpression, and 26/106 cases (24.5%) were positive for HPV DNA. Sixteen out of twenty-six samples were positive for both HPV DNA and p16INK4A staining. HPV16 could be isolated from 22/26 samples (84.6%) and was found to be the most frequently detected HPV type. This study represents the largest cohort of Turkish patients with HNSCC characterized according to HPV status and p16INK4A expression. Our data suggest that HPV16 infection, along with smoking, contribute to the development of HNSCC. |
| first_indexed | 2024-03-10T03:22:55Z |
| format | Article |
| id | doaj.art-eb0312ff82034d0c8a62e483dd5e7063 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T03:22:55Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-eb0312ff82034d0c8a62e483dd5e70632023-11-23T10:00:14ZengMDPI AGPathogens2076-08172021-11-011012153310.3390/pathogens10121533Genotype Distribution and Prevalence of Human Papillomavirus in Head and Neck Cancer Samples from Istanbul, TurkeyMuammer Osman Köksal0Başak Keskin Yalçın1Fahriye Keskin2Sevgi Çiftçi3Ibrahim Yağcı4Seyhan Özakkoyunlu Hasçiçek5Bora Başaran6Kemal Değer7Ali Ağaçfidan8Alexander Quaas9Baki Akgül10Department of Medical Microbiology, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, TurkeyDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Istanbul University, 34116 Istanbul, TurkeyUnit of Microbiology, Istanbul Faculty of Dentistry, Istanbul University, 34116 Istanbul, TurkeyUnit of Microbiology, Istanbul Faculty of Dentistry, Istanbul University, 34116 Istanbul, TurkeyDepartment of Otorhinolaryngology & Head and Neck Surgery, Sisli Hamidiye Training and Research Hospital, University of Health and Science, 34371 Istanbul, TurkeyDepartment of Pathology, Sisli Hamidiye Training and Research Hospital, University of Health and Science, 34371 Istanbul, TurkeyDepartment of Otorhinolaryngology & Head and Neck Surgery, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, TurkeyDepartment of Otorhinolaryngology & Head and Neck Surgery, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, TurkeyDepartment of Medical Microbiology, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, TurkeyInstitute of Pathology, University Hospital Cologne, 50937 Cologne, GermanyInstitute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, 50935 Cologne, GermanyHuman papillomavirus (HPV)-associated tumors account for a significant proportion of head and neck squamous cell carcinomas (HNSCC) in developed countries. In recent years, there has been a rise of HPV infections associated with HNSCC, especially HPV16, which is the most commonly detected type in oral and oropharyngeal cancers. To investigate the frequency of HPV-driven HNSCC among patients living in Turkey, HPV DNA positivity and p16INK4A expression were assessed in primary tumor biopsies (n = 106). Eighteen out of one hundred and six (19%) HNSCC tumors showed p16INK4A overexpression, and 26/106 cases (24.5%) were positive for HPV DNA. Sixteen out of twenty-six samples were positive for both HPV DNA and p16INK4A staining. HPV16 could be isolated from 22/26 samples (84.6%) and was found to be the most frequently detected HPV type. This study represents the largest cohort of Turkish patients with HNSCC characterized according to HPV status and p16INK4A expression. Our data suggest that HPV16 infection, along with smoking, contribute to the development of HNSCC.https://www.mdpi.com/2076-0817/10/12/1533head and neck squamous cell carcinoma (HNSCC)human papillomavirus (HPV)oral cavityoropharyngeal squamous cell carcinoma (OPSCC)p16INK4A |
| spellingShingle | Muammer Osman Köksal Başak Keskin Yalçın Fahriye Keskin Sevgi Çiftçi Ibrahim Yağcı Seyhan Özakkoyunlu Hasçiçek Bora Başaran Kemal Değer Ali Ağaçfidan Alexander Quaas Baki Akgül Genotype Distribution and Prevalence of Human Papillomavirus in Head and Neck Cancer Samples from Istanbul, Turkey Pathogens head and neck squamous cell carcinoma (HNSCC) human papillomavirus (HPV) oral cavity oropharyngeal squamous cell carcinoma (OPSCC) p16INK4A |
| title | Genotype Distribution and Prevalence of Human Papillomavirus in Head and Neck Cancer Samples from Istanbul, Turkey |
| title_full | Genotype Distribution and Prevalence of Human Papillomavirus in Head and Neck Cancer Samples from Istanbul, Turkey |
| title_fullStr | Genotype Distribution and Prevalence of Human Papillomavirus in Head and Neck Cancer Samples from Istanbul, Turkey |
| title_full_unstemmed | Genotype Distribution and Prevalence of Human Papillomavirus in Head and Neck Cancer Samples from Istanbul, Turkey |
| title_short | Genotype Distribution and Prevalence of Human Papillomavirus in Head and Neck Cancer Samples from Istanbul, Turkey |
| title_sort | genotype distribution and prevalence of human papillomavirus in head and neck cancer samples from istanbul turkey |
| topic | head and neck squamous cell carcinoma (HNSCC) human papillomavirus (HPV) oral cavity oropharyngeal squamous cell carcinoma (OPSCC) p16INK4A |
| url | https://www.mdpi.com/2076-0817/10/12/1533 |
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