Chronic Inflammation in Women with Polycystic Ovarian Syndrome
OBJECTIVE: Our aim was to assess whether C-reactive protein (CRP) which is not only a marker of inflammation but a strong predictor of atherosclerosis and coronary heart disease was increased among women with polycystic ovary syndrome (PCOS). STUDY DESIGN This cross-sectional study was carried out o...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Medical Network
2006-12-01
|
| Series: | Gynecology Obstetrics & Reproductive Medicine |
| Subjects: | |
| Online Access: | http://gorm.com.tr/index.php/GORM/article/view/599 |
| _version_ | 1797920398923268096 |
|---|---|
| author | Işık Üstüner Murat Sönmezer Cem Atabekoğlu Ahmet Ergun Sevim Güllü Ruşen Aytaç |
| author_facet | Işık Üstüner Murat Sönmezer Cem Atabekoğlu Ahmet Ergun Sevim Güllü Ruşen Aytaç |
| author_sort | Işık Üstüner |
| collection | DOAJ |
| description | OBJECTIVE: Our aim was to assess whether C-reactive protein (CRP) which is not only a marker of inflammation but a strong predictor of atherosclerosis and coronary heart disease was increased among women with polycystic ovary syndrome (PCOS).
STUDY DESIGN This cross-sectional study was carried out on 18 women with PCOS and 20 healthy subjects matched for body mass index (BMI) and age. Androgenic hormones, anthropometric measurements, metabolic parameters and serum CRP levels were assessed. Further analysis whether there was a correlation between CRP and other parameters was carried out in the PCOS group as well.
RESULTS: The androgenic hormones total testosterone (54.51±13.58 vs. 25.0±14.82 ng/dL, p<0.001), and androstenedione (3.7±1.1 vs. 2.78±1.19 ng/dL, p=0.049) were higher in the study group than in control subjects. Dehydroepiandrostenedione sulfate (DHEAS) (191.66±68.79 vs. 179.85±86.32
mg/dL), fasting insulin (15.1±4.1 vs. 14.5±1.7μIu/mL) and postprandial glucose (105±12.7 mg/dL vs. 97.4±10.8 mg/dL) were similar. Fasting glucose was higher in the study group compared to controls (96.1±7.9 vs. 86.6±8.9 mg/dL, p=0.007). Mean CRP levels were higher in patients with PCOS than in healthy controls (1.40±0.98 mg/dL and 0.88±0.39 mg/dL respectiv ely, p<0.001). Regression analysis revealed no correlation between CRP and other factors studied, except for a positive relationship that existed with BMI (r=0.286, p=0.045).
CONCLUSION: PCOS patients have increased levels of inf lamation marker CRP which may also signal the tendency to develop cardiovascular disease in addition to established risk factors among PCOS patients. |
| first_indexed | 2024-04-10T14:01:36Z |
| format | Article |
| id | doaj.art-eb036bf41d09402faa5abbf860c54a7c |
| institution | Directory Open Access Journal |
| issn | 1300-4751 |
| language | English |
| last_indexed | 2024-04-10T14:01:36Z |
| publishDate | 2006-12-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj.art-eb036bf41d09402faa5abbf860c54a7c2023-02-15T16:10:15ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512006-12-01123533Chronic Inflammation in Women with Polycystic Ovarian SyndromeIşık Üstüner0Murat Sönmezer1Cem Atabekoğlu2Ahmet Ergun3Sevim Güllü4Ruşen Aytaç5Department of Obstetrics & Gynecology, Ankara University School of Medicine, AnkaraDepartment of Obstetrics & Gynecology, Ankara University School of Medicine, AnkaraDepartment of Obstetrics & Gynecology, Ankara University School of Medicine, AnkaraDepartment of Physiology, Ankara University School of Medicine, AnkaraDepartment of Endocrinology and Metabolic Diseases, Ankara University School of Medicine, AnkaraDepartment of Obstetrics & Gynecology, Ankara University School of Medicine, AnkaraOBJECTIVE: Our aim was to assess whether C-reactive protein (CRP) which is not only a marker of inflammation but a strong predictor of atherosclerosis and coronary heart disease was increased among women with polycystic ovary syndrome (PCOS). STUDY DESIGN This cross-sectional study was carried out on 18 women with PCOS and 20 healthy subjects matched for body mass index (BMI) and age. Androgenic hormones, anthropometric measurements, metabolic parameters and serum CRP levels were assessed. Further analysis whether there was a correlation between CRP and other parameters was carried out in the PCOS group as well. RESULTS: The androgenic hormones total testosterone (54.51±13.58 vs. 25.0±14.82 ng/dL, p<0.001), and androstenedione (3.7±1.1 vs. 2.78±1.19 ng/dL, p=0.049) were higher in the study group than in control subjects. Dehydroepiandrostenedione sulfate (DHEAS) (191.66±68.79 vs. 179.85±86.32 mg/dL), fasting insulin (15.1±4.1 vs. 14.5±1.7μIu/mL) and postprandial glucose (105±12.7 mg/dL vs. 97.4±10.8 mg/dL) were similar. Fasting glucose was higher in the study group compared to controls (96.1±7.9 vs. 86.6±8.9 mg/dL, p=0.007). Mean CRP levels were higher in patients with PCOS than in healthy controls (1.40±0.98 mg/dL and 0.88±0.39 mg/dL respectiv ely, p<0.001). Regression analysis revealed no correlation between CRP and other factors studied, except for a positive relationship that existed with BMI (r=0.286, p=0.045). CONCLUSION: PCOS patients have increased levels of inf lamation marker CRP which may also signal the tendency to develop cardiovascular disease in addition to established risk factors among PCOS patients.http://gorm.com.tr/index.php/GORM/article/view/599Chronic inflammation, C-reactive protein, Polycystic ovary syndrome |
| spellingShingle | Işık Üstüner Murat Sönmezer Cem Atabekoğlu Ahmet Ergun Sevim Güllü Ruşen Aytaç Chronic Inflammation in Women with Polycystic Ovarian Syndrome Gynecology Obstetrics & Reproductive Medicine Chronic inflammation, C-reactive protein, Polycystic ovary syndrome |
| title | Chronic Inflammation in Women with Polycystic Ovarian Syndrome |
| title_full | Chronic Inflammation in Women with Polycystic Ovarian Syndrome |
| title_fullStr | Chronic Inflammation in Women with Polycystic Ovarian Syndrome |
| title_full_unstemmed | Chronic Inflammation in Women with Polycystic Ovarian Syndrome |
| title_short | Chronic Inflammation in Women with Polycystic Ovarian Syndrome |
| title_sort | chronic inflammation in women with polycystic ovarian syndrome |
| topic | Chronic inflammation, C-reactive protein, Polycystic ovary syndrome |
| url | http://gorm.com.tr/index.php/GORM/article/view/599 |
| work_keys_str_mv | AT isıkustuner chronicinflammationinwomenwithpolycysticovariansyndrome AT muratsonmezer chronicinflammationinwomenwithpolycysticovariansyndrome AT cematabekoglu chronicinflammationinwomenwithpolycysticovariansyndrome AT ahmetergun chronicinflammationinwomenwithpolycysticovariansyndrome AT sevimgullu chronicinflammationinwomenwithpolycysticovariansyndrome AT rusenaytac chronicinflammationinwomenwithpolycysticovariansyndrome |