Does overnight duty affect vascular endothelial function?
Abstract Background The reactive hyperemia index (RHI), which is obtained from the measurement of peripheral arterial tonometry (PAT), is highly associated with the percentage change in the end-diastolic arterial diameter (%flow-mediated dilatation) at reactive hyperemia. Low RHI is reported to be a...
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-021-02277-y |
| _version_ | 1818984827036106752 |
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| author | A. Garu Eri Nitta Yuri Yoshida Erika Yata Akari Tsunematsu Tsuyoshi Araki Atsushi Nagai Shozo Yano |
| author_facet | A. Garu Eri Nitta Yuri Yoshida Erika Yata Akari Tsunematsu Tsuyoshi Araki Atsushi Nagai Shozo Yano |
| author_sort | A. Garu |
| collection | DOAJ |
| description | Abstract Background The reactive hyperemia index (RHI), which is obtained from the measurement of peripheral arterial tonometry (PAT), is highly associated with the percentage change in the end-diastolic arterial diameter (%flow-mediated dilatation) at reactive hyperemia. Low RHI is reported to be a mortality risk in patients with a high risk of cardiovascular (CV) disease. CV events are thought to be induced by physical and mental stress, including long-term fatigue and lack of sleep. However, the relationship between fatigue, lack of sleep, and endothelial function has not yet been established. Methods Healthy hospital workers (n = 13, 6 men and 7 women) with an average age of 31.6 years were assigned to this study after they provided written informed consent. During the study period, we conducted 72 measurements of reactive hyperemia-peripheral arterial tonometry (RH-PAT) in the morning before or after their duty. At each measurement of the RH-PAT, we recorded the participants’ hours of sleep and evaluated their degree of fatigue using a visual analog scale (VAS). Results Although the VAS was significantly less (36 ± 16% and 64 ± 12%, p < 0.001) and the hours of sleep were longer (6.0 ± 1.1 h and 2.3 ± 1.0 h, p < 0.001) before duty compared to those after duty, the RHI was comparable between them (2.12 ± 0.53 vs. 1.97 ± 0.50, p = 0.21). The VAS score was significantly higher in participants with low RHI (< 1.67) than in those with normal RHI (≥ 2.07) (59 ± 13% and 46 ± 21%, respectively, p < 0.05). However, binary logistic regression showed no significant association between low RHI and the VAS when adjusted for systemic blood pressure (SBP) and heart rate variability (HRV). In a simple regression analysis, the RHI was significantly correlated with the VAS score but not with sleep duration. A multiple linear regression analysis also showed no significant association between the RHI and VAS scores after adjustment for SBP and HRV. Conclusions Vascular endothelial function was not associated with overnight duty, hours of sleep, or degree of fatigue in healthy young adults. Since the RHI may be decreased in severe fatigue conditions through autonomic nerve activity, one should consider the physical and mental conditions of the examinee when evaluating the RH-PAT results. |
| first_indexed | 2024-12-20T18:25:11Z |
| format | Article |
| id | doaj.art-eb07233b008a402489dcc25f7c1092f7 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-20T18:25:11Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-eb07233b008a402489dcc25f7c1092f72022-12-21T19:30:12ZengBMCBMC Cardiovascular Disorders1471-22612021-09-012111910.1186/s12872-021-02277-yDoes overnight duty affect vascular endothelial function?A. Garu0Eri Nitta1Yuri Yoshida2Erika Yata3Akari Tsunematsu4Tsuyoshi Araki5Atsushi Nagai6Shozo Yano7Department of Neurology, Faculty of Medicine, Shimane UniversityDepartment of Clinical Laboratory Medicine, Shimane University HospitalDepartment of Clinical Laboratory Medicine, Shimane University HospitalDepartment of Clinical Laboratory Medicine, Shimane University HospitalDepartment of Clinical Laboratory Medicine, Shimane University HospitalDepartment of Clinical Laboratory Medicine, Shimane University HospitalDepartment of Neurology, Faculty of Medicine, Shimane UniversityDepartment of Clinical Laboratory Medicine, Shimane University HospitalAbstract Background The reactive hyperemia index (RHI), which is obtained from the measurement of peripheral arterial tonometry (PAT), is highly associated with the percentage change in the end-diastolic arterial diameter (%flow-mediated dilatation) at reactive hyperemia. Low RHI is reported to be a mortality risk in patients with a high risk of cardiovascular (CV) disease. CV events are thought to be induced by physical and mental stress, including long-term fatigue and lack of sleep. However, the relationship between fatigue, lack of sleep, and endothelial function has not yet been established. Methods Healthy hospital workers (n = 13, 6 men and 7 women) with an average age of 31.6 years were assigned to this study after they provided written informed consent. During the study period, we conducted 72 measurements of reactive hyperemia-peripheral arterial tonometry (RH-PAT) in the morning before or after their duty. At each measurement of the RH-PAT, we recorded the participants’ hours of sleep and evaluated their degree of fatigue using a visual analog scale (VAS). Results Although the VAS was significantly less (36 ± 16% and 64 ± 12%, p < 0.001) and the hours of sleep were longer (6.0 ± 1.1 h and 2.3 ± 1.0 h, p < 0.001) before duty compared to those after duty, the RHI was comparable between them (2.12 ± 0.53 vs. 1.97 ± 0.50, p = 0.21). The VAS score was significantly higher in participants with low RHI (< 1.67) than in those with normal RHI (≥ 2.07) (59 ± 13% and 46 ± 21%, respectively, p < 0.05). However, binary logistic regression showed no significant association between low RHI and the VAS when adjusted for systemic blood pressure (SBP) and heart rate variability (HRV). In a simple regression analysis, the RHI was significantly correlated with the VAS score but not with sleep duration. A multiple linear regression analysis also showed no significant association between the RHI and VAS scores after adjustment for SBP and HRV. Conclusions Vascular endothelial function was not associated with overnight duty, hours of sleep, or degree of fatigue in healthy young adults. Since the RHI may be decreased in severe fatigue conditions through autonomic nerve activity, one should consider the physical and mental conditions of the examinee when evaluating the RH-PAT results.https://doi.org/10.1186/s12872-021-02277-yReactive hyperemia index (RHI)Peripheral arterial tonometry (PAT)Vascular endothelial functionFatigueSleep |
| spellingShingle | A. Garu Eri Nitta Yuri Yoshida Erika Yata Akari Tsunematsu Tsuyoshi Araki Atsushi Nagai Shozo Yano Does overnight duty affect vascular endothelial function? BMC Cardiovascular Disorders Reactive hyperemia index (RHI) Peripheral arterial tonometry (PAT) Vascular endothelial function Fatigue Sleep |
| title | Does overnight duty affect vascular endothelial function? |
| title_full | Does overnight duty affect vascular endothelial function? |
| title_fullStr | Does overnight duty affect vascular endothelial function? |
| title_full_unstemmed | Does overnight duty affect vascular endothelial function? |
| title_short | Does overnight duty affect vascular endothelial function? |
| title_sort | does overnight duty affect vascular endothelial function |
| topic | Reactive hyperemia index (RHI) Peripheral arterial tonometry (PAT) Vascular endothelial function Fatigue Sleep |
| url | https://doi.org/10.1186/s12872-021-02277-y |
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