MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma
MicroRNAs (miRNA) are small non-coding RNAs that are 20–23 nucleotides in length, functioning as regulators of oncogenes or tumor suppressor genes. They are molecular modulators that regulate gene expression by suppressing gene translation through gene silencing/degradation, or by promoting translat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/2/244 |
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| author | Botle Precious Setlai Rodney Hull Rui Manuel Reis Cyril Agbor Melvin Anyasi Ambele Thanyani Victor Mulaudzi Zodwa Dlamini |
| author_facet | Botle Precious Setlai Rodney Hull Rui Manuel Reis Cyril Agbor Melvin Anyasi Ambele Thanyani Victor Mulaudzi Zodwa Dlamini |
| author_sort | Botle Precious Setlai |
| collection | DOAJ |
| description | MicroRNAs (miRNA) are small non-coding RNAs that are 20–23 nucleotides in length, functioning as regulators of oncogenes or tumor suppressor genes. They are molecular modulators that regulate gene expression by suppressing gene translation through gene silencing/degradation, or by promoting translation of messenger RNA (mRNA) into proteins. Circulating miRNAs have attracted attention as possible prognostic markers of cancer, which could aid in the early detection of the disease. Epithelial to mesenchymal transition (EMT) has been implicated in tumorigenic processes, primarily by promoting tumor invasiveness and metastatic activity; this is a process that could be manipulated to halt or prevent brain metastasis. Studies show that miRNAs influence the function of EMT in glioblastomas. Thus, miRNA-related EMT can be exploited as a potential therapeutic target in glioblastomas. This review points out the interrelation between miRNA and EMT signatures, and how they can be used as reliable molecular signatures for diagnostic purposes or targeted therapy in glioblastomas. |
| first_indexed | 2024-03-09T21:53:18Z |
| format | Article |
| id | doaj.art-eb088c7c067747c5a63dff6570d8482b |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T21:53:18Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-eb088c7c067747c5a63dff6570d8482b2023-11-23T20:03:51ZengMDPI AGGenes2073-44252022-01-0113224410.3390/genes13020244MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in GlioblastomaBotle Precious Setlai0Rodney Hull1Rui Manuel Reis2Cyril Agbor3Melvin Anyasi Ambele4Thanyani Victor Mulaudzi5Zodwa Dlamini6Department of Surgery, Level 7, Bridge E, Steve Biko Academic Hospital, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Arcadia 0007, South AfricaSAMRC Precision Oncology Research Unit (PORU), Precision Oncology and Cancer Prevention (POCP), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0028, South AfricaSAMRC Precision Oncology Research Unit (PORU), Precision Oncology and Cancer Prevention (POCP), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0028, South AfricaDepartment of Surgery, Level 7, Bridge E, Steve Biko Academic Hospital, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Arcadia 0007, South AfricaDepartment of Oral Pathology and Oral Biology, School of Dentistry, Faculty of Health Sciences, University of Pretoria, P.O. Box 1266, Pretoria 0001, South AfricaDepartment of Surgery, Level 7, Bridge E, Steve Biko Academic Hospital, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Arcadia 0007, South AfricaSAMRC Precision Oncology Research Unit (PORU), Precision Oncology and Cancer Prevention (POCP), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0028, South AfricaMicroRNAs (miRNA) are small non-coding RNAs that are 20–23 nucleotides in length, functioning as regulators of oncogenes or tumor suppressor genes. They are molecular modulators that regulate gene expression by suppressing gene translation through gene silencing/degradation, or by promoting translation of messenger RNA (mRNA) into proteins. Circulating miRNAs have attracted attention as possible prognostic markers of cancer, which could aid in the early detection of the disease. Epithelial to mesenchymal transition (EMT) has been implicated in tumorigenic processes, primarily by promoting tumor invasiveness and metastatic activity; this is a process that could be manipulated to halt or prevent brain metastasis. Studies show that miRNAs influence the function of EMT in glioblastomas. Thus, miRNA-related EMT can be exploited as a potential therapeutic target in glioblastomas. This review points out the interrelation between miRNA and EMT signatures, and how they can be used as reliable molecular signatures for diagnostic purposes or targeted therapy in glioblastomas.https://www.mdpi.com/2073-4425/13/2/244microRNAEMTangiogenesisdrug resistance |
| spellingShingle | Botle Precious Setlai Rodney Hull Rui Manuel Reis Cyril Agbor Melvin Anyasi Ambele Thanyani Victor Mulaudzi Zodwa Dlamini MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma Genes microRNA EMT angiogenesis drug resistance |
| title | MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma |
| title_full | MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma |
| title_fullStr | MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma |
| title_full_unstemmed | MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma |
| title_short | MicroRNA Interrelated Epithelial Mesenchymal Transition (EMT) in Glioblastoma |
| title_sort | microrna interrelated epithelial mesenchymal transition emt in glioblastoma |
| topic | microRNA EMT angiogenesis drug resistance |
| url | https://www.mdpi.com/2073-4425/13/2/244 |
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