Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response

Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic response

Abstract Endothelial-to-mesenchymal transition (EndoMT), the process wherein endothelial cells lose endothelial identity and adopt mesenchymal-like phenotypes, constitutes a critical contributor to cardiac fibrosis. The phenotypic plasticity of endothelial cells can be intricately shaped by alterati...

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Bibliographic Details
Main Authors: Hao Zeng, Ting Pan, Meiling Zhan, Renaguli Hailiwu, Baolin Liu, Hua Yang, Ping Li
Format: Article
Language:English
Published: Nature Publishing Group 2022-09-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-01097-6

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