Feed Supplementation with the GHRP-6 Peptide, a Ghrelin Analog, Improves Feed Intake, Growth Performance and Aerobic Metabolism in the Gilthead Sea Bream <i>Sparus aurata</i>
The aquaculture sector has experienced rapid and important growth with the subsequent increase of feeding and nutritional issues for sustaining this activity, mainly related to the use of high quality, safe and environmentally friendly feed ingredients. The use of additives in aquafeeds has proven t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Fishes |
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| Online Access: | https://www.mdpi.com/2410-3888/7/1/31 |
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| author | Leandro Rodríguez-Viera Ignacio Martí Rebeca Martínez Erick Perera Mario Pablo Estrada Juan Miguel Mancera Juan Antonio Martos-Sitcha |
| author_facet | Leandro Rodríguez-Viera Ignacio Martí Rebeca Martínez Erick Perera Mario Pablo Estrada Juan Miguel Mancera Juan Antonio Martos-Sitcha |
| author_sort | Leandro Rodríguez-Viera |
| collection | DOAJ |
| description | The aquaculture sector has experienced rapid and important growth with the subsequent increase of feeding and nutritional issues for sustaining this activity, mainly related to the use of high quality, safe and environmentally friendly feed ingredients. The use of additives in aquafeeds has proven to be a suitable option to improve different productive indicators in farmed fish. In the present study, the effect of adding the GHRP-6 peptide, a ghrelin analog, to a commercial diet of gilthead sea bream (<i>Sparus aurata</i>) was studied at two proportions (100 or 500 μg/kg of feed). Both experimental diets show an increase in growth performance, as well as in feed efficiency after 97 days of experiment. The lower inclusion of GHRP-6 (100 μg/kg) results in a better aerobic metabolism, while the higher inclusion significantly increased plasma GH levels in agreement with the GH secretagogue effects of ghrelin. Similar growth outcome and differences between GHRP-6 levels in aerobic metabolism and GH stimulation suggest that improvements in culture performance by this peptide may occur through different mechanisms. Taken together, this compound can be considered as a viable dietary supplement for increasing production efficiency of sea bream aquaculture, although a better understanding of its dose-specific effects is still required. |
| first_indexed | 2024-03-09T22:00:04Z |
| format | Article |
| id | doaj.art-eb099311018b40569a8dc1e56ad1dbcd |
| institution | Directory Open Access Journal |
| issn | 2410-3888 |
| language | English |
| last_indexed | 2024-03-09T22:00:04Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Fishes |
| spelling | doaj.art-eb099311018b40569a8dc1e56ad1dbcd2023-11-23T19:51:40ZengMDPI AGFishes2410-38882022-01-01713110.3390/fishes7010031Feed Supplementation with the GHRP-6 Peptide, a Ghrelin Analog, Improves Feed Intake, Growth Performance and Aerobic Metabolism in the Gilthead Sea Bream <i>Sparus aurata</i>Leandro Rodríguez-Viera0Ignacio Martí1Rebeca Martínez2Erick Perera3Mario Pablo Estrada4Juan Miguel Mancera5Juan Antonio Martos-Sitcha6Center for Marine Research, University of Havana, Havana 10300, CubaDepartment of Biology, Faculty of Marine and Environmental Sciences, Instituto Universitario de Investigación Marina (INMAR), University of Cadiz, Campus de Excelencia Internacional del Mar (CEIMAR), 11519 Puerto Real, Cadiz, SpainAquatic Biotechnology Project, Center for Genetic Engineering and Biotechnology, Havana 10600, CubaAndalusian Institute of Marine Sciences (ICMAN), Spanish National Research Council (CSIC), 11519 Puerto Real, Cadiz, SpainAquatic Biotechnology Project, Center for Genetic Engineering and Biotechnology, Havana 10600, CubaDepartment of Biology, Faculty of Marine and Environmental Sciences, Instituto Universitario de Investigación Marina (INMAR), University of Cadiz, Campus de Excelencia Internacional del Mar (CEIMAR), 11519 Puerto Real, Cadiz, SpainDepartment of Biology, Faculty of Marine and Environmental Sciences, Instituto Universitario de Investigación Marina (INMAR), University of Cadiz, Campus de Excelencia Internacional del Mar (CEIMAR), 11519 Puerto Real, Cadiz, SpainThe aquaculture sector has experienced rapid and important growth with the subsequent increase of feeding and nutritional issues for sustaining this activity, mainly related to the use of high quality, safe and environmentally friendly feed ingredients. The use of additives in aquafeeds has proven to be a suitable option to improve different productive indicators in farmed fish. In the present study, the effect of adding the GHRP-6 peptide, a ghrelin analog, to a commercial diet of gilthead sea bream (<i>Sparus aurata</i>) was studied at two proportions (100 or 500 μg/kg of feed). Both experimental diets show an increase in growth performance, as well as in feed efficiency after 97 days of experiment. The lower inclusion of GHRP-6 (100 μg/kg) results in a better aerobic metabolism, while the higher inclusion significantly increased plasma GH levels in agreement with the GH secretagogue effects of ghrelin. Similar growth outcome and differences between GHRP-6 levels in aerobic metabolism and GH stimulation suggest that improvements in culture performance by this peptide may occur through different mechanisms. Taken together, this compound can be considered as a viable dietary supplement for increasing production efficiency of sea bream aquaculture, although a better understanding of its dose-specific effects is still required.https://www.mdpi.com/2410-3888/7/1/31aquacultureghrelingilthead sea breamgrowth hormone secretagoguefeed intakemetabolism |
| spellingShingle | Leandro Rodríguez-Viera Ignacio Martí Rebeca Martínez Erick Perera Mario Pablo Estrada Juan Miguel Mancera Juan Antonio Martos-Sitcha Feed Supplementation with the GHRP-6 Peptide, a Ghrelin Analog, Improves Feed Intake, Growth Performance and Aerobic Metabolism in the Gilthead Sea Bream <i>Sparus aurata</i> Fishes aquaculture ghrelin gilthead sea bream growth hormone secretagogue feed intake metabolism |
| title | Feed Supplementation with the GHRP-6 Peptide, a Ghrelin Analog, Improves Feed Intake, Growth Performance and Aerobic Metabolism in the Gilthead Sea Bream <i>Sparus aurata</i> |
| title_full | Feed Supplementation with the GHRP-6 Peptide, a Ghrelin Analog, Improves Feed Intake, Growth Performance and Aerobic Metabolism in the Gilthead Sea Bream <i>Sparus aurata</i> |
| title_fullStr | Feed Supplementation with the GHRP-6 Peptide, a Ghrelin Analog, Improves Feed Intake, Growth Performance and Aerobic Metabolism in the Gilthead Sea Bream <i>Sparus aurata</i> |
| title_full_unstemmed | Feed Supplementation with the GHRP-6 Peptide, a Ghrelin Analog, Improves Feed Intake, Growth Performance and Aerobic Metabolism in the Gilthead Sea Bream <i>Sparus aurata</i> |
| title_short | Feed Supplementation with the GHRP-6 Peptide, a Ghrelin Analog, Improves Feed Intake, Growth Performance and Aerobic Metabolism in the Gilthead Sea Bream <i>Sparus aurata</i> |
| title_sort | feed supplementation with the ghrp 6 peptide a ghrelin analog improves feed intake growth performance and aerobic metabolism in the gilthead sea bream i sparus aurata i |
| topic | aquaculture ghrelin gilthead sea bream growth hormone secretagogue feed intake metabolism |
| url | https://www.mdpi.com/2410-3888/7/1/31 |
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