Comparison between the Effect of Lidocaine or Ropivacaine Hematoma Block and of Different Timings of Administration on Post-Operative Pain in Dogs Undergoing Osteosynthesis of Long-Bone Fractures
Objective: We aimed to compare the efficacy of intra-operative lidocaine hematoma block (HB) to ropivacaine HB and to compare the efficacy of different timings of ropivacaine HB in controlling post-operative pain in dogs undergoing the osteosynthesis of long-bone fractures. Study Design: We conducte...
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MDPI AG
2023-09-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/18/2858 |
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| author | Irene Dimopoulou Tilemachos Anagnostou Ioannis Savvas Panagiota Karamichali Nikitas Prassinos |
| author_facet | Irene Dimopoulou Tilemachos Anagnostou Ioannis Savvas Panagiota Karamichali Nikitas Prassinos |
| author_sort | Irene Dimopoulou |
| collection | DOAJ |
| description | Objective: We aimed to compare the efficacy of intra-operative lidocaine hematoma block (HB) to ropivacaine HB and to compare the efficacy of different timings of ropivacaine HB in controlling post-operative pain in dogs undergoing the osteosynthesis of long-bone fractures. Study Design: We conducted a randomized, blinded, prospective clinical study. Animals: Forty-eight dogs with long-bone fractures were included and were randomly allocated to four groups: lidocaine (L), ropivacaine (Rmid), ropivacaine pre- (Rpre) and ropivacaine post- (Rpost) groups. Methods: The dogs in group L (n = 14) and in group Rmid (n = 11) received a lidocaine or ropivacaine HB, respectively, after fracture reduction and before osteosynthesis material placement. Rpre dogs (n = 11) received ropivacaine HB before fracture reduction, and Rpost dogs (n = 12) received ropivacaine HB after osteosynthesis material placement. Eight post-operative pain assessments were performed using the University of Melbourne Pain Scale (UMPS) and an algometer. Rescue analgesia was administered based on UMPS scoring. For data analysis, the Shapiro–Wilk test of normality, chi-square, Student t test and Split Plot analysis were used. The level of significance was set at α = 0.05. Results: Rescue analgesia was administered to one dog in group L, one in group Rmid and one in group Rpost, with no significant differences detected. Compared to group Rmid, group L dogs exhibited significantly higher mean mechanical pain thresholds (<i>p</i> = 0.049) and lower mean UMPS scores (<i>p</i> = 0.001). Group Rpost dogs had statistically significantly higher mean pain thresholds compared to group Rmid (<i>p</i> = 0.009). Clinical Implications: When performed after fracture reduction and before osteosynthesis material placement, lidocaine HB seems to be more effective than ropivacaine HB in controlling post-operative pain in dogs undergoing osteosynthesis of long-bone fractures. The administration of ropivacaine HB after osteosynthesis material placement seems to be more effective than administration after fracture reduction and before osteosynthesis material placement or administration before fracture reduction in controlling post-operative pain in dogs undergoing osteosynthesis of long-bone fractures. |
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| publishDate | 2023-09-01 |
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| spelling | doaj.art-eb0b7b0ed977475fa8c7759f7eac62a62023-11-19T09:14:35ZengMDPI AGAnimals2076-26152023-09-011318285810.3390/ani13182858Comparison between the Effect of Lidocaine or Ropivacaine Hematoma Block and of Different Timings of Administration on Post-Operative Pain in Dogs Undergoing Osteosynthesis of Long-Bone FracturesIrene Dimopoulou0Tilemachos Anagnostou1Ioannis Savvas2Panagiota Karamichali3Nikitas Prassinos4Anaesthesia, Analgesia, Emergency and Critical Care Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University, 54627 Thessaloniki, GreeceAnaesthesia, Analgesia, Emergency and Critical Care Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University, 54627 Thessaloniki, GreeceAnaesthesia, Analgesia, Emergency and Critical Care Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University, 54627 Thessaloniki, GreeceAnaesthesia, Analgesia, Emergency and Critical Care Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University, 54627 Thessaloniki, GreeceSurgery & Obstetrics Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University, 54627 Thessaloniki, GreeceObjective: We aimed to compare the efficacy of intra-operative lidocaine hematoma block (HB) to ropivacaine HB and to compare the efficacy of different timings of ropivacaine HB in controlling post-operative pain in dogs undergoing the osteosynthesis of long-bone fractures. Study Design: We conducted a randomized, blinded, prospective clinical study. Animals: Forty-eight dogs with long-bone fractures were included and were randomly allocated to four groups: lidocaine (L), ropivacaine (Rmid), ropivacaine pre- (Rpre) and ropivacaine post- (Rpost) groups. Methods: The dogs in group L (n = 14) and in group Rmid (n = 11) received a lidocaine or ropivacaine HB, respectively, after fracture reduction and before osteosynthesis material placement. Rpre dogs (n = 11) received ropivacaine HB before fracture reduction, and Rpost dogs (n = 12) received ropivacaine HB after osteosynthesis material placement. Eight post-operative pain assessments were performed using the University of Melbourne Pain Scale (UMPS) and an algometer. Rescue analgesia was administered based on UMPS scoring. For data analysis, the Shapiro–Wilk test of normality, chi-square, Student t test and Split Plot analysis were used. The level of significance was set at α = 0.05. Results: Rescue analgesia was administered to one dog in group L, one in group Rmid and one in group Rpost, with no significant differences detected. Compared to group Rmid, group L dogs exhibited significantly higher mean mechanical pain thresholds (<i>p</i> = 0.049) and lower mean UMPS scores (<i>p</i> = 0.001). Group Rpost dogs had statistically significantly higher mean pain thresholds compared to group Rmid (<i>p</i> = 0.009). Clinical Implications: When performed after fracture reduction and before osteosynthesis material placement, lidocaine HB seems to be more effective than ropivacaine HB in controlling post-operative pain in dogs undergoing osteosynthesis of long-bone fractures. The administration of ropivacaine HB after osteosynthesis material placement seems to be more effective than administration after fracture reduction and before osteosynthesis material placement or administration before fracture reduction in controlling post-operative pain in dogs undergoing osteosynthesis of long-bone fractures.https://www.mdpi.com/2076-2615/13/18/2858analgesiadoghematoma blocklidocainelocal anaestheticsropivacaine |
| spellingShingle | Irene Dimopoulou Tilemachos Anagnostou Ioannis Savvas Panagiota Karamichali Nikitas Prassinos Comparison between the Effect of Lidocaine or Ropivacaine Hematoma Block and of Different Timings of Administration on Post-Operative Pain in Dogs Undergoing Osteosynthesis of Long-Bone Fractures Animals analgesia dog hematoma block lidocaine local anaesthetics ropivacaine |
| title | Comparison between the Effect of Lidocaine or Ropivacaine Hematoma Block and of Different Timings of Administration on Post-Operative Pain in Dogs Undergoing Osteosynthesis of Long-Bone Fractures |
| title_full | Comparison between the Effect of Lidocaine or Ropivacaine Hematoma Block and of Different Timings of Administration on Post-Operative Pain in Dogs Undergoing Osteosynthesis of Long-Bone Fractures |
| title_fullStr | Comparison between the Effect of Lidocaine or Ropivacaine Hematoma Block and of Different Timings of Administration on Post-Operative Pain in Dogs Undergoing Osteosynthesis of Long-Bone Fractures |
| title_full_unstemmed | Comparison between the Effect of Lidocaine or Ropivacaine Hematoma Block and of Different Timings of Administration on Post-Operative Pain in Dogs Undergoing Osteosynthesis of Long-Bone Fractures |
| title_short | Comparison between the Effect of Lidocaine or Ropivacaine Hematoma Block and of Different Timings of Administration on Post-Operative Pain in Dogs Undergoing Osteosynthesis of Long-Bone Fractures |
| title_sort | comparison between the effect of lidocaine or ropivacaine hematoma block and of different timings of administration on post operative pain in dogs undergoing osteosynthesis of long bone fractures |
| topic | analgesia dog hematoma block lidocaine local anaesthetics ropivacaine |
| url | https://www.mdpi.com/2076-2615/13/18/2858 |
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