Quantitative Proteomics Reveal That CB2R Agonist JWH-133 Downregulates NF-κB Activation, Oxidative Stress, and Lysosomal Exocytosis from HIV-Infected Macrophages
HIV-associated neurocognitive disorders (HAND) affect 15–55% of HIV-positive patients and effective therapies are unavailable. HIV-infected monocyte-derived macrophages (MDM) invade the brain of these individuals, promoting neurotoxicity. We demonstrated an increased expression of cathepsin B (CATB)...
Main Authors: | Lester J. Rosario-Rodríguez, Yadira M. Cantres-Rosario, Kelvin Carrasquillo-Carrión, Ana E. Rodríguez-De Jesús, Luz J. Cartagena-Isern, Luis A. García-Requena, Abiel Roche-Lima, Loyda M. Meléndez |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2024-03-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/25/6/3246 |
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