Therapeutic response of immunoglobulin 4-related aortitis and pancreatitis demonstrated by diffusion-weighted MRI

Immunoglobulin (IgG) 4-related disease is a systemic inflammatory disease, and it affects vascular system as aortitis, periaortitis, or aneurysm. However, due to a lack of serum biomarker on aortic damage and the multiorgan involvement, it is difficult to assess aortic inflammatory activity of IgG4-...

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Bibliographic Details
Main Authors: Shogo Doi, Yasuyoshi Kuroiwa, PhD, Kazunori Kusumoto, MD, Atsushi Yamashita, MD, PhD, Eiji Furukoji, MD, PhD, Hiroshi Tai, MD, Yasushi Kihara, MD, Toshinori Hirai, MD, PhD, Yujiro Asada, MD, PhD, Takuroh Imamura, MD, PhD
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Radiology Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S1930043319302365
Description
Summary:Immunoglobulin (IgG) 4-related disease is a systemic inflammatory disease, and it affects vascular system as aortitis, periaortitis, or aneurysm. However, due to a lack of serum biomarker on aortic damage and the multiorgan involvement, it is difficult to assess aortic inflammatory activity of IgG4-related disease. We described a case of IgG4-related pancreatitis and aortitis, which was visualized with magnetic resonance merged image of diffusion weighted and T1 weighted images. The aortic signal intensity or apparent diffusion coefficient value reduced or increased after oral prednisone administration, respectively. Magnetic resonance diffusion weighted image and apparent diffusion coefficient may be a useful imaging tool for assessment of vascular inflammation in IgG4-related aortitis. Keywords: Immunoglobulin (IgG) 4-related disease, Aortitis, Magnetic resonance imaging, Diffusion weighted imaging
ISSN:1930-0433