Acid-Sensing Ion Channels in Glial Cells
Acid-sensing ion channels (ASICs) are proton-gated cation channels and key mediators of responses to neuronal injury. ASICs exhibit unique patterns of distribution in the brain, with high expression in neurons and low expression in glial cells. While there has been a lot of focus on ASIC in neurons,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Membranes |
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| Online Access: | https://www.mdpi.com/2077-0375/12/2/119 |
| _version_ | 1827654118536118272 |
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| author | Victoria Cegielski Rohan Chakrabarty Shinghua Ding Michael J. Wacker Paula Monaghan-Nichols Xiang-Ping Chu |
| author_facet | Victoria Cegielski Rohan Chakrabarty Shinghua Ding Michael J. Wacker Paula Monaghan-Nichols Xiang-Ping Chu |
| author_sort | Victoria Cegielski |
| collection | DOAJ |
| description | Acid-sensing ion channels (ASICs) are proton-gated cation channels and key mediators of responses to neuronal injury. ASICs exhibit unique patterns of distribution in the brain, with high expression in neurons and low expression in glial cells. While there has been a lot of focus on ASIC in neurons, less is known about the roles of ASICs in glial cells. ASIC1a is expressed in astrocytes and might contribute to synaptic transmission and long-term potentiation. In oligodendrocytes, constitutive activation of ASIC1a participates in demyelinating diseases. ASIC1a, ASIC2a, and ASIC3, found in microglial cells, could mediate the inflammatory response. Under pathological conditions, ASIC dysregulation in glial cells can contribute to disease states. For example, activation of astrocytic ASIC1a may worsen neurodegeneration and glioma staging, activation of microglial ASIC1a and ASIC2a may perpetuate ischemia and inflammation, while oligodendrocytic ASIC1a might be involved in multiple sclerosis. This review concentrates on the unique ASIC components in each of the glial cells and integrates these glial-specific ASICs with their physiological and pathological conditions. Such knowledge provides promising evidence for targeting of ASICs in individual glial cells as a therapeutic strategy for a diverse range of conditions. |
| first_indexed | 2024-03-09T21:29:02Z |
| format | Article |
| id | doaj.art-eb0d6f01487e4ea4a6a43100456fb1ba |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-09T21:29:02Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-eb0d6f01487e4ea4a6a43100456fb1ba2023-11-23T21:02:08ZengMDPI AGMembranes2077-03752022-01-0112211910.3390/membranes12020119Acid-Sensing Ion Channels in Glial CellsVictoria Cegielski0Rohan Chakrabarty1Shinghua Ding2Michael J. Wacker3Paula Monaghan-Nichols4Xiang-Ping Chu5Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USADepartment of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USADepartment of Biomedical, Biological and Chemical Engineering, University of Missouri-Columbia, Columbia, MO 65211, USADepartment of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USADepartment of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USADepartment of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USAAcid-sensing ion channels (ASICs) are proton-gated cation channels and key mediators of responses to neuronal injury. ASICs exhibit unique patterns of distribution in the brain, with high expression in neurons and low expression in glial cells. While there has been a lot of focus on ASIC in neurons, less is known about the roles of ASICs in glial cells. ASIC1a is expressed in astrocytes and might contribute to synaptic transmission and long-term potentiation. In oligodendrocytes, constitutive activation of ASIC1a participates in demyelinating diseases. ASIC1a, ASIC2a, and ASIC3, found in microglial cells, could mediate the inflammatory response. Under pathological conditions, ASIC dysregulation in glial cells can contribute to disease states. For example, activation of astrocytic ASIC1a may worsen neurodegeneration and glioma staging, activation of microglial ASIC1a and ASIC2a may perpetuate ischemia and inflammation, while oligodendrocytic ASIC1a might be involved in multiple sclerosis. This review concentrates on the unique ASIC components in each of the glial cells and integrates these glial-specific ASICs with their physiological and pathological conditions. Such knowledge provides promising evidence for targeting of ASICs in individual glial cells as a therapeutic strategy for a diverse range of conditions.https://www.mdpi.com/2077-0375/12/2/119acid-sensing ion channelsglial cellsastrocytemicrogliaoligodendrocyteexpression |
| spellingShingle | Victoria Cegielski Rohan Chakrabarty Shinghua Ding Michael J. Wacker Paula Monaghan-Nichols Xiang-Ping Chu Acid-Sensing Ion Channels in Glial Cells Membranes acid-sensing ion channels glial cells astrocyte microglia oligodendrocyte expression |
| title | Acid-Sensing Ion Channels in Glial Cells |
| title_full | Acid-Sensing Ion Channels in Glial Cells |
| title_fullStr | Acid-Sensing Ion Channels in Glial Cells |
| title_full_unstemmed | Acid-Sensing Ion Channels in Glial Cells |
| title_short | Acid-Sensing Ion Channels in Glial Cells |
| title_sort | acid sensing ion channels in glial cells |
| topic | acid-sensing ion channels glial cells astrocyte microglia oligodendrocyte expression |
| url | https://www.mdpi.com/2077-0375/12/2/119 |
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