Anti-Inflammatory Effect of Fermented Cabbage Extract Containing Nitric Oxide Metabolites with Silica
The aim of this study was to evaluate the anti-inflammatory effect of fermented cabbage extract (FC) containing nitric oxide metabolites with silica (FCS) on 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis (AD) in BALB/c mice. Atopic dermatitis-like allergic contact dermatitis was...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/2/775 |
| _version_ | 1797339910808535040 |
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| author | Yun-Seong Lee Byeong-Jun Ji Hyun-Ock Pae Mu-Weon Cheon Guangpeng Xu Hyun-Soo Chun Sooah Kim |
| author_facet | Yun-Seong Lee Byeong-Jun Ji Hyun-Ock Pae Mu-Weon Cheon Guangpeng Xu Hyun-Soo Chun Sooah Kim |
| author_sort | Yun-Seong Lee |
| collection | DOAJ |
| description | The aim of this study was to evaluate the anti-inflammatory effect of fermented cabbage extract (FC) containing nitric oxide metabolites with silica (FCS) on 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis (AD) in BALB/c mice. Atopic dermatitis-like allergic contact dermatitis was induced by DNFB challenge in the ear after DNFB sensitization on the dorsal skin of mice. FCS alleviated the severity of atopic dermatitis-like skin lesions. In addition, epidermis thickness of the ear and penetration of inflammatory cells in atopic dermatitis-like skin lesions were decreased after topical application of FCS. The serum levels of TNF-α and IL-4 were measured in atopic dermatitis mice using ELISA kits, which were observed to be significantly decreased after topical application of FCS. This study demonstrates that the FCS can be used as a potential therapeutic for the treatment and prevention of AD. |
| first_indexed | 2024-03-08T09:54:19Z |
| format | Article |
| id | doaj.art-eb0d7604ab05445f81627d0f923eace8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T09:54:19Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-eb0d7604ab05445f81627d0f923eace82024-01-29T13:54:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-01-0125277510.3390/ijms25020775Anti-Inflammatory Effect of Fermented Cabbage Extract Containing Nitric Oxide Metabolites with SilicaYun-Seong Lee0Byeong-Jun Ji1Hyun-Ock Pae2Mu-Weon Cheon3Guangpeng Xu4Hyun-Soo Chun5Sooah Kim6Department of Microbiology and Immunology, School of Medicine, Wonkwang University, Iksan 54538, Republic of KoreaHumanEnos LLC., Wanju 55347, Republic of KoreaDepartment of Microbiology and Immunology, School of Medicine, Wonkwang University, Iksan 54538, Republic of KoreaDepartment of Chemistry, KwangWoon University, Seoul 01897, Republic of KoreaDepartment of Environment Science & Biotechnology, Jeonju University, Jeonju 55069, Republic of KoreaHumanEnos LLC., Wanju 55347, Republic of KoreaDepartment of Environment Science & Biotechnology, Jeonju University, Jeonju 55069, Republic of KoreaThe aim of this study was to evaluate the anti-inflammatory effect of fermented cabbage extract (FC) containing nitric oxide metabolites with silica (FCS) on 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis (AD) in BALB/c mice. Atopic dermatitis-like allergic contact dermatitis was induced by DNFB challenge in the ear after DNFB sensitization on the dorsal skin of mice. FCS alleviated the severity of atopic dermatitis-like skin lesions. In addition, epidermis thickness of the ear and penetration of inflammatory cells in atopic dermatitis-like skin lesions were decreased after topical application of FCS. The serum levels of TNF-α and IL-4 were measured in atopic dermatitis mice using ELISA kits, which were observed to be significantly decreased after topical application of FCS. This study demonstrates that the FCS can be used as a potential therapeutic for the treatment and prevention of AD.https://www.mdpi.com/1422-0067/25/2/775atopic dermatitisfermented cabbage extractnitric oxide metabolitessilicaanti-inflammatory |
| spellingShingle | Yun-Seong Lee Byeong-Jun Ji Hyun-Ock Pae Mu-Weon Cheon Guangpeng Xu Hyun-Soo Chun Sooah Kim Anti-Inflammatory Effect of Fermented Cabbage Extract Containing Nitric Oxide Metabolites with Silica International Journal of Molecular Sciences atopic dermatitis fermented cabbage extract nitric oxide metabolites silica anti-inflammatory |
| title | Anti-Inflammatory Effect of Fermented Cabbage Extract Containing Nitric Oxide Metabolites with Silica |
| title_full | Anti-Inflammatory Effect of Fermented Cabbage Extract Containing Nitric Oxide Metabolites with Silica |
| title_fullStr | Anti-Inflammatory Effect of Fermented Cabbage Extract Containing Nitric Oxide Metabolites with Silica |
| title_full_unstemmed | Anti-Inflammatory Effect of Fermented Cabbage Extract Containing Nitric Oxide Metabolites with Silica |
| title_short | Anti-Inflammatory Effect of Fermented Cabbage Extract Containing Nitric Oxide Metabolites with Silica |
| title_sort | anti inflammatory effect of fermented cabbage extract containing nitric oxide metabolites with silica |
| topic | atopic dermatitis fermented cabbage extract nitric oxide metabolites silica anti-inflammatory |
| url | https://www.mdpi.com/1422-0067/25/2/775 |
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