Research progress on the role of NLRP3 inflammasome in the treatment of ischemia-reperfusion injury
NOD-like receptor protein 3(NLRP3) inflammasome, as a protein complex that constitutes the innate immune system, can mediate inflammatory responses by regulating the maturation and release of IL-1β and IL-18, which are the basic for multiple pathological injury. A variety of injury factors generated...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2023-04-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-4-706.pdf |
| Summary: | NOD-like receptor protein 3(NLRP3) inflammasome, as a protein complex that constitutes the innate immune system, can mediate inflammatory responses by regulating the maturation and release of IL-1β and IL-18, which are the basic for multiple pathological injury. A variety of injury factors generated during ischemia-reperfusion injury (I/RI) can activate the NLRP3 inflammasome, resulting in the excessive release of IL-1β and IL-18, which in turn leads to an inflammatory cascade to aggravate the damage of various tissues and organs. Inhibition of NLRP3 inflammasome activation has become an effective method to alleviate organ I/RI. Therefore, exploring the detailed mechanism of NLRP3 inflammasome-mediated I/RI can provide a theoretical basis for the prevention and treatment of organ I/RI. |
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| ISSN: | 1001-6325 |