Vitamin K Deficiency Induced by Warfarin Is Associated With Cognitive and Behavioral Perturbations, and Alterations in Brain Sphingolipids in Rats

Vitamin K Deficiency Induced by Warfarin Is Associated With Cognitive and Behavioral Perturbations, and Alterations in Brain Sphingolipids in Rats

Initially discovered for its role in blood coagulation, there is now convincing evidence that vitamin K (VK) has important actions in the nervous system. In brain, VK is present in the form of menaquinone-4 (MK-4), a byproduct of the main dietary source, phylloquinone. It contributes to the biologic...

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Bibliographic Details
Main Authors: Sahar Tamadon-Nejad, Bouchra Ouliass, Joseph Rochford, Guylaine Ferland
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
vitamin K
menaquinone-4
nutritional deficiency
brain
cognition
sphingolipids
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00213/full

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