Epigenetics in Pancreatic Ductal Adenocarcinoma: Impact on Biology and Utilization in Diagnostics and Treatment

Epigenetics in Pancreatic Ductal Adenocarcinoma: Impact on Biology and Utilization in Diagnostics and Treatment

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies with high potential of metastases and therapeutic resistance. Although genetic mutations drive PDAC initiation, they alone do not explain its aggressive nature. Epigenetic mechanisms, including aberrant DNA methylatio...

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Bibliographic Details
Main Authors: Asmaa Elrakaybi, Dietrich A. Ruess, Michael Lübbert, Michael Quante, Heiko Becker
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
epigenetics
cfDNA methylation
DNMT inhibitors
HDAC inhibitors
retinoids
Online Access:https://www.mdpi.com/2072-6694/14/23/5926

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