Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells

Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells

Soluble CD83 (sCD83) is the extracellular domain of the membrane-bound CD83 molecule, and known for its immunoregulatory functions. Whether and how sCD83 participates in the pathogenesis of uveitis, a serious inflammatory disease of the eye that can cause visual disability and blindness, is unknown....

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Bibliographic Details
Main Authors: Wei Lin, Konrad Buscher, Beibei Wang, Zhichao Fan, Nannan Song, Peng Li, Yingying Yue, Bingqing Li, Cuiling Li, Hongsheng Bi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
soluble CD83
dendritic cells
calcium response
filamentous actin
T cells
experimental autoimmune uveitis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01567/full

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