Kidney Microcirculation as a Target for Innovative Therapies in AKI
Acute kidney injury (AKI) is a serious multifactorial conditions accompanied by the loss of function and damage. The renal microcirculation plays a crucial role in maintaining the kidney’s functional and structural integrity for oxygen and nutrient supply and waste product removal. However, alterati...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/10/18/4041 |
| _version_ | 1797518773663563776 |
|---|---|
| author | Bülent Ergin Sakir Akin Can Ince |
| author_facet | Bülent Ergin Sakir Akin Can Ince |
| author_sort | Bülent Ergin |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is a serious multifactorial conditions accompanied by the loss of function and damage. The renal microcirculation plays a crucial role in maintaining the kidney’s functional and structural integrity for oxygen and nutrient supply and waste product removal. However, alterations in microcirculation and oxygenation due to renal perfusion defects, hypoxia, renal tubular, and endothelial damage can result in AKI and the loss of renal function regardless of systemic hemodynamic changes. The unique structural organization of the renal microvasculature and the presence of autoregulation make it difficult to understand the mechanisms and the occurrence of AKI following disorders such as septic, hemorrhagic, or cardiogenic shock; ischemia/reperfusion; chronic heart failure; cardiorenal syndrome; and hemodilution. In this review, we describe the organization of microcirculation, autoregulation, and pathophysiological alterations leading to AKI. We then suggest innovative therapies focused on the protection of the renal microcirculation and oxygenation to prevent AKI. |
| first_indexed | 2024-03-10T07:34:20Z |
| format | Article |
| id | doaj.art-eb15fec189324933955195b965fc7e80 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T07:34:20Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-eb15fec189324933955195b965fc7e802023-11-22T13:38:36ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-011018404110.3390/jcm10184041Kidney Microcirculation as a Target for Innovative Therapies in AKIBülent Ergin0Sakir Akin1Can Ince2Department of Intensive Care, Laboratory of Translational Intensive Care, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The NetherlandsDepartment of Intensive Care, Haga Teaching Hospital, 2545 AA The Hague, The NetherlandsDepartment of Intensive Care, Laboratory of Translational Intensive Care, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The NetherlandsAcute kidney injury (AKI) is a serious multifactorial conditions accompanied by the loss of function and damage. The renal microcirculation plays a crucial role in maintaining the kidney’s functional and structural integrity for oxygen and nutrient supply and waste product removal. However, alterations in microcirculation and oxygenation due to renal perfusion defects, hypoxia, renal tubular, and endothelial damage can result in AKI and the loss of renal function regardless of systemic hemodynamic changes. The unique structural organization of the renal microvasculature and the presence of autoregulation make it difficult to understand the mechanisms and the occurrence of AKI following disorders such as septic, hemorrhagic, or cardiogenic shock; ischemia/reperfusion; chronic heart failure; cardiorenal syndrome; and hemodilution. In this review, we describe the organization of microcirculation, autoregulation, and pathophysiological alterations leading to AKI. We then suggest innovative therapies focused on the protection of the renal microcirculation and oxygenation to prevent AKI.https://www.mdpi.com/2077-0383/10/18/4041acute kidney injurymicrocirculationoxygenationinnovative therapies |
| spellingShingle | Bülent Ergin Sakir Akin Can Ince Kidney Microcirculation as a Target for Innovative Therapies in AKI Journal of Clinical Medicine acute kidney injury microcirculation oxygenation innovative therapies |
| title | Kidney Microcirculation as a Target for Innovative Therapies in AKI |
| title_full | Kidney Microcirculation as a Target for Innovative Therapies in AKI |
| title_fullStr | Kidney Microcirculation as a Target for Innovative Therapies in AKI |
| title_full_unstemmed | Kidney Microcirculation as a Target for Innovative Therapies in AKI |
| title_short | Kidney Microcirculation as a Target for Innovative Therapies in AKI |
| title_sort | kidney microcirculation as a target for innovative therapies in aki |
| topic | acute kidney injury microcirculation oxygenation innovative therapies |
| url | https://www.mdpi.com/2077-0383/10/18/4041 |
| work_keys_str_mv | AT bulentergin kidneymicrocirculationasatargetforinnovativetherapiesinaki AT sakirakin kidneymicrocirculationasatargetforinnovativetherapiesinaki AT canince kidneymicrocirculationasatargetforinnovativetherapiesinaki |