Cardiovascular Characteristics and Outcomes of Young Patients with COVID-19
Although 18–45-year-old (y-o) patients represent a significant proportion of patients hospitalized for COVID-19, data concerning the young population remain scarce. The Critical COVID France (CCF) study was an observational study including consecutive patients hospitalized for COVID-19 in 24 centers...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/8/12/165 |
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| author | Antonin Trimaille Sophie Ribeyrolles Charles Fauvel Corentin Chaumont Orianne Weizman Thibaut Pommier Joffrey Cellier Laura Geneste Vassili Panagides Wassima Marsou Antoine Deney Sabir Attou Thomas Delmotte Pascale Chemaly Clément Karsenty Gauthier Giordano Alexandre Gautier Pierre Guilleminot Audrey Sagnard Julie Pastier Baptiste Duceau Willy Sutter Victor Waldmann Théo Pezel Delphine Mika Ariel Cohen Guillaume Bonnet the Critical COVID-19 France Investigators |
| author_facet | Antonin Trimaille Sophie Ribeyrolles Charles Fauvel Corentin Chaumont Orianne Weizman Thibaut Pommier Joffrey Cellier Laura Geneste Vassili Panagides Wassima Marsou Antoine Deney Sabir Attou Thomas Delmotte Pascale Chemaly Clément Karsenty Gauthier Giordano Alexandre Gautier Pierre Guilleminot Audrey Sagnard Julie Pastier Baptiste Duceau Willy Sutter Victor Waldmann Théo Pezel Delphine Mika Ariel Cohen Guillaume Bonnet the Critical COVID-19 France Investigators |
| author_sort | Antonin Trimaille |
| collection | DOAJ |
| description | Although 18–45-year-old (y-o) patients represent a significant proportion of patients hospitalized for COVID-19, data concerning the young population remain scarce. The Critical COVID France (CCF) study was an observational study including consecutive patients hospitalized for COVID-19 in 24 centers between 26 February and 20 April 2020. The primary composite outcome included transfer to the intensive care unit (ICU) or in-hospital death. Secondary outcomes were cardiovascular (CV) complications. Among 2868 patients, 321 (11.2%) patients were in the 18–45-y-o range. In comparison with older patients, young patients were more likely to have class 2 obesity and less likely to have hypertension, diabetes and dyslipidemia. The primary outcome occurred less frequently in 18–45-y-o patients in comparison with patients > 45 years old (y/o) (16.8% vs. 30.7%, <i>p</i> < 0.001). The 18–45-y-o patients presented with pericarditis (2.2% vs. 0.5%, <i>p</i> = 0.003) and myocarditis (2.5% vs. 0.6%, <i>p</i> = 0.002) more frequently than patients >45 y/o. Acute heart failure occurred less frequently in 18–45-y-o patients (0.9% vs. 7.2%, <i>p</i> < 0.001), while thrombotic complications were similar in young and older patients. Whereas both transfer to the ICU and in-hospital death occurred less frequently in young patients, COVID-19 seemed to have a particular CV impact in this population. |
| first_indexed | 2024-03-10T03:52:11Z |
| format | Article |
| id | doaj.art-eb1be77898db45918119858cca02b743 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T03:52:11Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-eb1be77898db45918119858cca02b7432023-11-23T08:54:49ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252021-11-0181216510.3390/jcdd8120165Cardiovascular Characteristics and Outcomes of Young Patients with COVID-19Antonin Trimaille0Sophie Ribeyrolles1Charles Fauvel2Corentin Chaumont3Orianne Weizman4Thibaut Pommier5Joffrey Cellier6Laura Geneste7Vassili Panagides8Wassima Marsou9Antoine Deney10Sabir Attou11Thomas Delmotte12Pascale Chemaly13Clément Karsenty14Gauthier Giordano15Alexandre Gautier16Pierre Guilleminot17Audrey Sagnard18Julie Pastier19Baptiste Duceau20Willy Sutter21Victor Waldmann22Théo Pezel23Delphine Mika24Ariel Cohen25Guillaume Bonnet26the Critical COVID-19 France InvestigatorsCentre Hospitalier Régional Universitaire de Strasbourg, 67000 Strasbourg, FranceInstitut Mutualiste Montsouris, 75014 Paris, FranceCentre Hospitalier Universitaire de Rouen, 76000 Rouen, FranceCentre Hospitalier Universitaire de Rouen, 76000 Rouen, FranceCentre Hospitalier Régional Universitaire de Nancy, 54511 Vandœuvre-Lès-Nancy, FranceCentre Hospitalier Universitaire de Dijon, 21000 Dijon, FranceHôpital Européen Georges Pompidou, Université de Paris, 75015 Paris, FranceCentre Hospitalier Universitaire d’Amiens-Picardie, 80000 Amiens, FranceCentre Hospitalier Universitaire de Marseille, 13005 Marseille, FranceFaculté de Médecine et de Maïeutique, GCS-Groupement des Hôpitaux de l’Institut Catholique de Lille, Université Catholique de Lille, 59800 Lille, FranceCentre Hospitalier Universitaire de Toulouse, 31400 Toulouse, FranceCentre Hospitalier Universitaire de Caen-Normandie, 14000 Caen, FranceCentre Hospitalier Universitaire de Reims, 51100 Reims, FranceInstitut Cardiovasculaire Paris Sud, Massy, 91300 Paris, FranceCentre Hospitalier Universitaire de Toulouse, 31400 Toulouse, FranceCentre Hospitalier Régional Universitaire de Nancy, 54511 Vandœuvre-Lès-Nancy, FranceInstitut Cardiovasculaire Paris Sud, Massy, 91300 Paris, FranceCentre Hospitalier Universitaire de Dijon, 21000 Dijon, FranceCentre Hospitalier Universitaire de Dijon, 21000 Dijon, FranceCentre Hospitalier Universitaire de Dijon, 21000 Dijon, FranceParis Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM, UMR-S970, Université de Paris, 75015 Paris, FranceHôpital Européen Georges Pompidou, Université de Paris, 75015 Paris, FranceHôpital Européen Georges Pompidou, Université de Paris, 75015 Paris, FranceHôpital Lariboisière, APHP, Université de Paris, 75010 Paris, FranceSignaling and Cardiovascular Pathophysiology, Inserm, UMR-S 1180, Université Paris-Saclay, Chatenay-Malabry, 92296 Paris, FranceHôpital Saint Antoine, 75012 Paris, FranceParis Cardiovascular Research Center (PARCC), Paris Translational Research Center for Organ Transplantation, INSERM, UMR-S970, Université de Paris, 75015 Paris, FranceAlthough 18–45-year-old (y-o) patients represent a significant proportion of patients hospitalized for COVID-19, data concerning the young population remain scarce. The Critical COVID France (CCF) study was an observational study including consecutive patients hospitalized for COVID-19 in 24 centers between 26 February and 20 April 2020. The primary composite outcome included transfer to the intensive care unit (ICU) or in-hospital death. Secondary outcomes were cardiovascular (CV) complications. Among 2868 patients, 321 (11.2%) patients were in the 18–45-y-o range. In comparison with older patients, young patients were more likely to have class 2 obesity and less likely to have hypertension, diabetes and dyslipidemia. The primary outcome occurred less frequently in 18–45-y-o patients in comparison with patients > 45 years old (y/o) (16.8% vs. 30.7%, <i>p</i> < 0.001). The 18–45-y-o patients presented with pericarditis (2.2% vs. 0.5%, <i>p</i> = 0.003) and myocarditis (2.5% vs. 0.6%, <i>p</i> = 0.002) more frequently than patients >45 y/o. Acute heart failure occurred less frequently in 18–45-y-o patients (0.9% vs. 7.2%, <i>p</i> < 0.001), while thrombotic complications were similar in young and older patients. Whereas both transfer to the ICU and in-hospital death occurred less frequently in young patients, COVID-19 seemed to have a particular CV impact in this population.https://www.mdpi.com/2308-3425/8/12/165COVID-19SARS-CoV-2youngmyocarditispericarditis |
| spellingShingle | Antonin Trimaille Sophie Ribeyrolles Charles Fauvel Corentin Chaumont Orianne Weizman Thibaut Pommier Joffrey Cellier Laura Geneste Vassili Panagides Wassima Marsou Antoine Deney Sabir Attou Thomas Delmotte Pascale Chemaly Clément Karsenty Gauthier Giordano Alexandre Gautier Pierre Guilleminot Audrey Sagnard Julie Pastier Baptiste Duceau Willy Sutter Victor Waldmann Théo Pezel Delphine Mika Ariel Cohen Guillaume Bonnet the Critical COVID-19 France Investigators Cardiovascular Characteristics and Outcomes of Young Patients with COVID-19 Journal of Cardiovascular Development and Disease COVID-19 SARS-CoV-2 young myocarditis pericarditis |
| title | Cardiovascular Characteristics and Outcomes of Young Patients with COVID-19 |
| title_full | Cardiovascular Characteristics and Outcomes of Young Patients with COVID-19 |
| title_fullStr | Cardiovascular Characteristics and Outcomes of Young Patients with COVID-19 |
| title_full_unstemmed | Cardiovascular Characteristics and Outcomes of Young Patients with COVID-19 |
| title_short | Cardiovascular Characteristics and Outcomes of Young Patients with COVID-19 |
| title_sort | cardiovascular characteristics and outcomes of young patients with covid 19 |
| topic | COVID-19 SARS-CoV-2 young myocarditis pericarditis |
| url | https://www.mdpi.com/2308-3425/8/12/165 |
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