Increased levels of the calcification marker Matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease
<p>Abstract</p> <p>Objective and design</p> <p>Low grade inflammation is of pathogenic importance in atherosclerosis and in the development of cardiovascular disease (CVD) and type 2 diabetes (T2D). Matrix GLA protein (MGP), an inhibitor of medial calcification of arter...
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| Format: | Article |
| Language: | English |
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BMC
2010-12-01
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| Series: | Cardiovascular Diabetology |
| Online Access: | http://www.cardiab.com/content/9/1/86 |
| _version_ | 1811251254349791232 |
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| author | Zerahn Bo Rathcke Camilla N Thomsen Stine B Vestergaard Henrik |
| author_facet | Zerahn Bo Rathcke Camilla N Thomsen Stine B Vestergaard Henrik |
| author_sort | Zerahn Bo |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Objective and design</p> <p>Low grade inflammation is of pathogenic importance in atherosclerosis and in the development of cardiovascular disease (CVD) and type 2 diabetes (T2D). Matrix GLA protein (MGP), an inhibitor of medial calcification of arteries, is increased in patients with atherosclerosis. In the present study levels of markers of calcification (MGP) and inflammation (YKL-40, hsCRP) were evaluated in patients with T2 D and/or ischemic heart disease (IHD).</p> <p>Materials and methods</p> <p>The study population consisted of 1) patients with T2D (n = 45); 2) patients with IHD (n = 37); patients with both T2D and IHD (n = 20) and 4) healthy controls (n = 20). Biochemical parameters were measured in venous blood samples.</p> <p>Results</p> <p>Levels of MGP, YKL-40 and hsCRP were increased in patients with IHD and/or T2D (p < 0.0001) and patients with T2D and IHD had higher MGP levels (p < 0.001). In multiple linear regression analyses MGP was associated with patient category (r = 0.36, p < 0.001), and HDL-cholesterol levels (r = 0.29, p < 0.001) adjusting for the significant covariates.</p> <p>Conclusions</p> <p>In patients with T2D and/or IHD we found increased levels of plasma MGP indicative of a progressing calcification process. This process is paralleled by increased levels of YKL-40 and hsCRP, which most likely reflect the concomitant low grade inflammatory state in these patients</p> |
| first_indexed | 2024-04-12T16:17:45Z |
| format | Article |
| id | doaj.art-eb1c0d9c274b416981b9cc5755a5a72f |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-04-12T16:17:45Z |
| publishDate | 2010-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-eb1c0d9c274b416981b9cc5755a5a72f2022-12-22T03:25:41ZengBMCCardiovascular Diabetology1475-28402010-12-01918610.1186/1475-2840-9-86Increased levels of the calcification marker Matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart diseaseZerahn BoRathcke Camilla NThomsen Stine BVestergaard Henrik<p>Abstract</p> <p>Objective and design</p> <p>Low grade inflammation is of pathogenic importance in atherosclerosis and in the development of cardiovascular disease (CVD) and type 2 diabetes (T2D). Matrix GLA protein (MGP), an inhibitor of medial calcification of arteries, is increased in patients with atherosclerosis. In the present study levels of markers of calcification (MGP) and inflammation (YKL-40, hsCRP) were evaluated in patients with T2 D and/or ischemic heart disease (IHD).</p> <p>Materials and methods</p> <p>The study population consisted of 1) patients with T2D (n = 45); 2) patients with IHD (n = 37); patients with both T2D and IHD (n = 20) and 4) healthy controls (n = 20). Biochemical parameters were measured in venous blood samples.</p> <p>Results</p> <p>Levels of MGP, YKL-40 and hsCRP were increased in patients with IHD and/or T2D (p < 0.0001) and patients with T2D and IHD had higher MGP levels (p < 0.001). In multiple linear regression analyses MGP was associated with patient category (r = 0.36, p < 0.001), and HDL-cholesterol levels (r = 0.29, p < 0.001) adjusting for the significant covariates.</p> <p>Conclusions</p> <p>In patients with T2D and/or IHD we found increased levels of plasma MGP indicative of a progressing calcification process. This process is paralleled by increased levels of YKL-40 and hsCRP, which most likely reflect the concomitant low grade inflammatory state in these patients</p>http://www.cardiab.com/content/9/1/86 |
| spellingShingle | Zerahn Bo Rathcke Camilla N Thomsen Stine B Vestergaard Henrik Increased levels of the calcification marker Matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease Cardiovascular Diabetology |
| title | Increased levels of the calcification marker Matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease |
| title_full | Increased levels of the calcification marker Matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease |
| title_fullStr | Increased levels of the calcification marker Matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease |
| title_full_unstemmed | Increased levels of the calcification marker Matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease |
| title_short | Increased levels of the calcification marker Matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease |
| title_sort | increased levels of the calcification marker matrix gla protein and the inflammatory markers ykl 40 and crp in patients with type 2 diabetes and ischemic heart disease |
| url | http://www.cardiab.com/content/9/1/86 |
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