Assisted Design of Antibody and Protein Therapeutics (ADAPT).
Effective biologic therapeutics require binding affinities that are fine-tuned to their disease-related molecular target. The ADAPT (Assisted Design of Antibody and Protein Therapeutics) platform aids in the selection of mutants that improve/modulate the affinity of antibodies and other biologics. I...
Main Authors: | Victor Vivcharuk, Jason Baardsnes, Christophe Deprez, Traian Sulea, Maria Jaramillo, Christopher R Corbeil, Alaka Mullick, Joanne Magoon, Anne Marcil, Yves Durocher, Maureen D O'Connor-McCourt, Enrico O Purisima |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5531539?pdf=render |
Similar Items
-
Solvated interaction energy: from small-molecule to antibody drug design
by: Enrico O. Purisima, et al.
Published: (2023-06-01) -
Redesigning an antibody H3 loop by virtual screening of a small library of human germline-derived sequences
by: Christopher R. Corbeil, et al.
Published: (2021-11-01) -
Exploring rigid-backbone protein docking in biologics discovery: a test using the DARPin scaffold
by: Francis Gaudreault, et al.
Published: (2023-08-01) -
Coevolved Canonical Loops Conformations of Single-Domain Antibodies: A Tale of Three Pockets Playing Musical Chairs
by: Francis Gaudreault, et al.
Published: (2022-06-01) -
Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates.
by: John C Zwaagstra, et al.
Published: (2019-01-01)