Neutrophil‐to‐lymphocyte ratio and D‐dimer are biomarkers of death risk in severe COVID‐19: A retrospective observational study
Abstract Background and Aims Over 4 million deaths from coronavirus disease (COVID)‐19 have been reported in the world. Several biomarkers have been identified that predict disease severity, but there is still a need to identify biomarkers for death risk in severe COVID‐19. We aim to define amongst...
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| Format: | Article |
| Language: | English |
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Wiley
2022-03-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.514 |
| _version_ | 1827294410902077440 |
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| author | Patrícia Oliveira Cunha Terra Camila Dermínio Donadel Luciana Correa Oliveira Mayra Gonçalves Menegueti Maria Auxiliadora‐Martins Rodrigo Tocantins Calado Gil Cunha De Santis |
| author_facet | Patrícia Oliveira Cunha Terra Camila Dermínio Donadel Luciana Correa Oliveira Mayra Gonçalves Menegueti Maria Auxiliadora‐Martins Rodrigo Tocantins Calado Gil Cunha De Santis |
| author_sort | Patrícia Oliveira Cunha Terra |
| collection | DOAJ |
| description | Abstract Background and Aims Over 4 million deaths from coronavirus disease (COVID)‐19 have been reported in the world. Several biomarkers have been identified that predict disease severity, but there is still a need to identify biomarkers for death risk in severe COVID‐19. We aim to define amongst the biomarkers already identified those which are mostly associated with increased death rate in patients with severe COVID‐19. Methods In this retrospective study conducted in three public hospitals linked to the Medical School of Ribeirão Preto, Brazil, patients with severe COVID‐19 were evaluated regarding biomarkers (neutrophil‐to‐lymphocyte ratio‐NLR, D‐dimer, fibrinogen) of death risk, obtained before administration of corticosteroids. Results Thirty‐nine (32.8%) of the 119 patients included (104 [87.4%] on mechanical ventilation) died during hospitalization. Non‐survivor group had higher median (range) NLR (12.63 [2.6‐115] vs 7.43 [0.43‐31.8]; P = .001), D‐dimer (2.17 [0.27‐20.00] vs 1.57 [0.28‐20.00]; P = .03), but lower fibrinogen (631 [353‐1078] vs 705 [407‐1200]; P = .02). The group with NLR ≥ 10 and D‐dimer ≥ 2 μg/mL had a higher death risk than the group with NLR < 10 and D‐dimer < 2 μg/mL (OR: 5.39; CI 95%: 1.5‐19.42; P = .01). Conclusion High NLR and D‐dimer, especially when combined, are predictors of death risk for patients with severe COVID‐19 and should be incorporated into their evaluation. |
| first_indexed | 2024-03-12T13:33:50Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-04-24T14:01:42Z |
| publishDate | 2022-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-eb1ee78381174df19096c755752867052024-04-03T12:41:03ZengWileyHealth Science Reports2398-88352022-03-0152n/an/a10.1002/hsr2.514Neutrophil‐to‐lymphocyte ratio and D‐dimer are biomarkers of death risk in severe COVID‐19: A retrospective observational studyPatrícia Oliveira Cunha Terra0Camila Dermínio Donadel1Luciana Correa Oliveira2Mayra Gonçalves Menegueti3Maria Auxiliadora‐Martins4Rodrigo Tocantins Calado5Gil Cunha De Santis6Department of Medical Imaging, Hematology, and Oncology Ribeirão Preto Medical School, University of São Paulo São Paulo BrazilDepartment of Medical Imaging, Hematology, and Oncology Ribeirão Preto Medical School, University of São Paulo São Paulo BrazilDepartment of Medical Imaging, Hematology, and Oncology Ribeirão Preto Medical School, University of São Paulo São Paulo BrazilRibeirão Preto Nursing School University of São Paulo São Paulo BrazilDivision of Intensive Medicine Ribeirão Preto Medical School, University of São Paulo São Paulo BrazilDepartment of Medical Imaging, Hematology, and Oncology Ribeirão Preto Medical School, University of São Paulo São Paulo BrazilDepartment of Medical Imaging, Hematology, and Oncology Ribeirão Preto Medical School, University of São Paulo São Paulo BrazilAbstract Background and Aims Over 4 million deaths from coronavirus disease (COVID)‐19 have been reported in the world. Several biomarkers have been identified that predict disease severity, but there is still a need to identify biomarkers for death risk in severe COVID‐19. We aim to define amongst the biomarkers already identified those which are mostly associated with increased death rate in patients with severe COVID‐19. Methods In this retrospective study conducted in three public hospitals linked to the Medical School of Ribeirão Preto, Brazil, patients with severe COVID‐19 were evaluated regarding biomarkers (neutrophil‐to‐lymphocyte ratio‐NLR, D‐dimer, fibrinogen) of death risk, obtained before administration of corticosteroids. Results Thirty‐nine (32.8%) of the 119 patients included (104 [87.4%] on mechanical ventilation) died during hospitalization. Non‐survivor group had higher median (range) NLR (12.63 [2.6‐115] vs 7.43 [0.43‐31.8]; P = .001), D‐dimer (2.17 [0.27‐20.00] vs 1.57 [0.28‐20.00]; P = .03), but lower fibrinogen (631 [353‐1078] vs 705 [407‐1200]; P = .02). The group with NLR ≥ 10 and D‐dimer ≥ 2 μg/mL had a higher death risk than the group with NLR < 10 and D‐dimer < 2 μg/mL (OR: 5.39; CI 95%: 1.5‐19.42; P = .01). Conclusion High NLR and D‐dimer, especially when combined, are predictors of death risk for patients with severe COVID‐19 and should be incorporated into their evaluation.https://doi.org/10.1002/hsr2.514biomarkersCOVID‐19critical careD‐dimerneutrophil‐to‐lymphocyte ratio |
| spellingShingle | Patrícia Oliveira Cunha Terra Camila Dermínio Donadel Luciana Correa Oliveira Mayra Gonçalves Menegueti Maria Auxiliadora‐Martins Rodrigo Tocantins Calado Gil Cunha De Santis Neutrophil‐to‐lymphocyte ratio and D‐dimer are biomarkers of death risk in severe COVID‐19: A retrospective observational study Health Science Reports biomarkers COVID‐19 critical care D‐dimer neutrophil‐to‐lymphocyte ratio |
| title | Neutrophil‐to‐lymphocyte ratio and D‐dimer are biomarkers of death risk in severe COVID‐19: A retrospective observational study |
| title_full | Neutrophil‐to‐lymphocyte ratio and D‐dimer are biomarkers of death risk in severe COVID‐19: A retrospective observational study |
| title_fullStr | Neutrophil‐to‐lymphocyte ratio and D‐dimer are biomarkers of death risk in severe COVID‐19: A retrospective observational study |
| title_full_unstemmed | Neutrophil‐to‐lymphocyte ratio and D‐dimer are biomarkers of death risk in severe COVID‐19: A retrospective observational study |
| title_short | Neutrophil‐to‐lymphocyte ratio and D‐dimer are biomarkers of death risk in severe COVID‐19: A retrospective observational study |
| title_sort | neutrophil to lymphocyte ratio and d dimer are biomarkers of death risk in severe covid 19 a retrospective observational study |
| topic | biomarkers COVID‐19 critical care D‐dimer neutrophil‐to‐lymphocyte ratio |
| url | https://doi.org/10.1002/hsr2.514 |
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