Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia
Human serum paraoxonase 1 (PON1) is an enzyme with esterase activity, and is physically bound to high-density lipoproteins (HDL). It plays a key role in the action of HDL toward protection of lipoprotein and biological membrane against oxidative damage. It may have a protective role against atherosc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=3;spage=402;epage=412;aulast=Kota |
| _version_ | 1818564239734865920 |
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| author | Sunil K Kota Lalit K Meher Siva K Kota Sruti Jammula S. V. S. Krishna Kirtikumar D Modi |
| author_facet | Sunil K Kota Lalit K Meher Siva K Kota Sruti Jammula S. V. S. Krishna Kirtikumar D Modi |
| author_sort | Sunil K Kota |
| collection | DOAJ |
| description | Human serum paraoxonase 1 (PON1) is an enzyme with esterase activity, and is physically bound to high-density lipoproteins (HDL). It plays a key role in the action of HDL toward protection of lipoprotein and biological membrane against oxidative damage. It may have a protective role against atherosclerosis by virtue of its action on hydrolyzing lipid peroxides and preventing accumulation of phospholipids in oxidized low-density lipoprotein (LDL). PON1 is hypothesized to be an indicator of the risk of atherosclerosis and coronary artery disease development. Numerous studies have implicated PON1 activity in relation to various endocrine disorders. The current article reviews the clinical perspectives of PON1 activity with regards to obesity, diabetes mellitus with its complications, and dyslipidemia. |
| first_indexed | 2024-12-14T01:26:32Z |
| format | Article |
| id | doaj.art-eb205e7bd27a4ca3ab5d2675a79e4aad |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-12-14T01:26:32Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-eb205e7bd27a4ca3ab5d2675a79e4aad2022-12-21T23:22:10ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002013-01-0117340241210.4103/2230-8210.111618Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemiaSunil K KotaLalit K MeherSiva K KotaSruti JammulaS. V. S. KrishnaKirtikumar D ModiHuman serum paraoxonase 1 (PON1) is an enzyme with esterase activity, and is physically bound to high-density lipoproteins (HDL). It plays a key role in the action of HDL toward protection of lipoprotein and biological membrane against oxidative damage. It may have a protective role against atherosclerosis by virtue of its action on hydrolyzing lipid peroxides and preventing accumulation of phospholipids in oxidized low-density lipoprotein (LDL). PON1 is hypothesized to be an indicator of the risk of atherosclerosis and coronary artery disease development. Numerous studies have implicated PON1 activity in relation to various endocrine disorders. The current article reviews the clinical perspectives of PON1 activity with regards to obesity, diabetes mellitus with its complications, and dyslipidemia.http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=3;spage=402;epage=412;aulast=KotaDiabetes mellitusdyslipidemiahigh-density lipoproteinobesityparaoxonase |
| spellingShingle | Sunil K Kota Lalit K Meher Siva K Kota Sruti Jammula S. V. S. Krishna Kirtikumar D Modi Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia Indian Journal of Endocrinology and Metabolism Diabetes mellitus dyslipidemia high-density lipoprotein obesity paraoxonase |
| title | Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia |
| title_full | Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia |
| title_fullStr | Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia |
| title_full_unstemmed | Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia |
| title_short | Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia |
| title_sort | implications of serum paraoxonase activity in obesity diabetes mellitus and dyslipidemia |
| topic | Diabetes mellitus dyslipidemia high-density lipoprotein obesity paraoxonase |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=3;spage=402;epage=412;aulast=Kota |
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