Association of single nucleotide polymorphism in patatin like phopholipase domain containing 3 (PNPLA3) gene with paediatric non-alcoholic fatty liver disease
Background: Non-alcoholic fatty liver disease (NAFLD) is the most unabating cause of chronic liver disease in children and adolescents. This study aimed to examine the association of single nucleotide polymorphism in patatin-like phospholipase domain containing 3 (PNPLA3) gene with paediatric non-a...
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| Format: | Article |
| Language: | English |
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Bangabandhu Sheikh Mujib Medical University
2023-09-01
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| Series: | Bangabandhu Sheikh Mujib Medical University Journal |
| Subjects: | |
| Online Access: | https://banglajol.info/index.php/BSMMUJ/article/view/68260 |
| _version_ | 1797654531330277376 |
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| author | Rubaiyat Alam Kaniz Fathema Md Rukunuzzaman Khan Lamia Nahid Sharmin Mahbuba Lubana Akram Abu Naser Ibne Sattar |
| author_facet | Rubaiyat Alam Kaniz Fathema Md Rukunuzzaman Khan Lamia Nahid Sharmin Mahbuba Lubana Akram Abu Naser Ibne Sattar |
| author_sort | Rubaiyat Alam |
| collection | DOAJ |
| description |
Background: Non-alcoholic fatty liver disease (NAFLD) is the most unabating cause of chronic liver disease in children and adolescents. This study aimed to examine the association of single nucleotide polymorphism in patatin-like phospholipase domain containing 3 (PNPLA3) gene with paediatric non-alcoholic fatty liver disease.
Methods: This case-control study was conducted from June 2021 to December 2022. Fifty-one overweight children aged 6–17 years were recruited in this study and divided into NAFLD (cases) and non-NAFLD (controls) groups based on hepatic steatosis detected by liver ultrasonography. We analysed the rs738409 polymorphism by TaqMan assay and examined its association with NAFLD.
Results: Thirty-one (60.8%) children were in the case group and 20 (39.2%) children were in the control group. Alanine aminotransferase (P<0.001) and triglycerides (P=0.02) were found to be significantly higher in cases. However, no significant association was found between the PNPLA3 rs738409 single nucleotide polymorphism (SNP) and the presence of NAFLD in children.
Conclusion: Our study didn't find any association between PNPLA3 rs 738409 single nucleotide polymorphisms and presence of NAFLD in children, but we discovered that high alanine aminotransferase and triglycerides level can be useful in screening overweight children for NAFLD.
Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 139-143
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| first_indexed | 2024-03-11T17:00:50Z |
| format | Article |
| id | doaj.art-eb23448bcd924126b444ff06e1607a26 |
| institution | Directory Open Access Journal |
| issn | 2074-2908 2224-7750 |
| language | English |
| last_indexed | 2024-03-11T17:00:50Z |
| publishDate | 2023-09-01 |
| publisher | Bangabandhu Sheikh Mujib Medical University |
| record_format | Article |
| series | Bangabandhu Sheikh Mujib Medical University Journal |
| spelling | doaj.art-eb23448bcd924126b444ff06e1607a262023-10-20T11:37:11ZengBangabandhu Sheikh Mujib Medical UniversityBangabandhu Sheikh Mujib Medical University Journal2074-29082224-77502023-09-0116310.3329/bsmmuj.v16i3.68260Association of single nucleotide polymorphism in patatin like phopholipase domain containing 3 (PNPLA3) gene with paediatric non-alcoholic fatty liver diseaseRubaiyat Alam0Kaniz Fathema1Md Rukunuzzaman2Khan Lamia Nahid3Sharmin Mahbuba4Lubana Akram5Abu Naser Ibne Sattar6Department of Paediatric Gastroenterology and Nutrition, Bangabandhu Sheikh Mujib Medical University, Dhaka, BangladeshDepartment of Paediatric Gastroenterology and Nutrition Sir Salimullah medical college & Hospital, Dhaka, BangladeshPediatric Endocrinology wing, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, BangladeshDepartment of Paediatric Gastroenterology and Nutrition, Bangabandhu Sheikh Mujib Medical University, Dhaka, BangladeshPediatric Endocrinology wing, Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, BangladeshDepartment of Paediatric Gastroenterology and Nutrition, Bangabandhu Sheikh Mujib Medical University, Dhaka, BangladeshDepartment of Microbiology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Background: Non-alcoholic fatty liver disease (NAFLD) is the most unabating cause of chronic liver disease in children and adolescents. This study aimed to examine the association of single nucleotide polymorphism in patatin-like phospholipase domain containing 3 (PNPLA3) gene with paediatric non-alcoholic fatty liver disease. Methods: This case-control study was conducted from June 2021 to December 2022. Fifty-one overweight children aged 6–17 years were recruited in this study and divided into NAFLD (cases) and non-NAFLD (controls) groups based on hepatic steatosis detected by liver ultrasonography. We analysed the rs738409 polymorphism by TaqMan assay and examined its association with NAFLD. Results: Thirty-one (60.8%) children were in the case group and 20 (39.2%) children were in the control group. Alanine aminotransferase (P<0.001) and triglycerides (P=0.02) were found to be significantly higher in cases. However, no significant association was found between the PNPLA3 rs738409 single nucleotide polymorphism (SNP) and the presence of NAFLD in children. Conclusion: Our study didn't find any association between PNPLA3 rs 738409 single nucleotide polymorphisms and presence of NAFLD in children, but we discovered that high alanine aminotransferase and triglycerides level can be useful in screening overweight children for NAFLD. Bangabandhu Sheikh Mujib Medical University Journal 2023;16(3): 139-143 https://banglajol.info/index.php/BSMMUJ/article/view/68260children, fatty liver, obesity, PNPLA3 gene, single nucleotide polymorphism |
| spellingShingle | Rubaiyat Alam Kaniz Fathema Md Rukunuzzaman Khan Lamia Nahid Sharmin Mahbuba Lubana Akram Abu Naser Ibne Sattar Association of single nucleotide polymorphism in patatin like phopholipase domain containing 3 (PNPLA3) gene with paediatric non-alcoholic fatty liver disease Bangabandhu Sheikh Mujib Medical University Journal children, fatty liver, obesity, PNPLA3 gene, single nucleotide polymorphism |
| title | Association of single nucleotide polymorphism in patatin like phopholipase domain containing 3 (PNPLA3) gene with paediatric non-alcoholic fatty liver disease |
| title_full | Association of single nucleotide polymorphism in patatin like phopholipase domain containing 3 (PNPLA3) gene with paediatric non-alcoholic fatty liver disease |
| title_fullStr | Association of single nucleotide polymorphism in patatin like phopholipase domain containing 3 (PNPLA3) gene with paediatric non-alcoholic fatty liver disease |
| title_full_unstemmed | Association of single nucleotide polymorphism in patatin like phopholipase domain containing 3 (PNPLA3) gene with paediatric non-alcoholic fatty liver disease |
| title_short | Association of single nucleotide polymorphism in patatin like phopholipase domain containing 3 (PNPLA3) gene with paediatric non-alcoholic fatty liver disease |
| title_sort | association of single nucleotide polymorphism in patatin like phopholipase domain containing 3 pnpla3 gene with paediatric non alcoholic fatty liver disease |
| topic | children, fatty liver, obesity, PNPLA3 gene, single nucleotide polymorphism |
| url | https://banglajol.info/index.php/BSMMUJ/article/view/68260 |
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