Clinicopathologic Characterization of Prostatic Cancer in Dogs
Clinicopathologic data in dogs with prostate cancer (PCa) may aid in the differentiation between tumor types and subsequent treatment decisions; however, these data are often unreported. Demographic, clinicopathologic, cytologic, histologic and survival data from dogs with primary prostatic adenocar...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/14/4/588 |
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| author | Demitria M. Vasilatis Paramita M. Ghosh |
| author_facet | Demitria M. Vasilatis Paramita M. Ghosh |
| author_sort | Demitria M. Vasilatis |
| collection | DOAJ |
| description | Clinicopathologic data in dogs with prostate cancer (PCa) may aid in the differentiation between tumor types and subsequent treatment decisions; however, these data are often unreported. Demographic, clinicopathologic, cytologic, histologic and survival data from dogs with primary prostatic adenocarcinoma (PRAD) (<i>n</i> = 56) and primary prostatic transitional cell carcinoma (P-TCC) (<i>n</i> = 74) were acquired from a tertiary veterinary teaching hospital from 1992 to 2022. Red blood cell distribution width (RDW) to albumin ratio (RAR) was evaluated for diagnostic utility in differentiating between PRAD and P-TCC. Sections from PRAD tumors (<i>n</i> = 50) were stained for androgen receptor (AR) expression, and laboratory data were compared between AR positive (AR+) and AR negative (AR−) groups. RDW was increased in PRAD, while albumin was decreased (<i>p</i> < 0.05). P-TCC was associated with Melamed-Wolinska bodies (MWB) and necrosis on cytology (<i>p</i> < 0.05). RAR had acceptable diagnostic utility in the differentiation of PCa tumors (AUC = 0.7; <i>p</i> < 0.05). Survival rates and metastases were equivocal. AR+ and AR− PRAD tumors did not differ in clinicopathologic data or survival (<i>p</i> > 0.05). In conclusion, hypoalbuminemia was significantly associated with PRAD and decreased survival, while MWB and necrosis were significantly associated with P-TCC on cytology. These clinicopathologic data may help clinicians differentiate between these tumors ante mortem to guide appropriate treatment and intervention. |
| first_indexed | 2024-03-07T22:46:07Z |
| format | Article |
| id | doaj.art-eb23c0c0f3884653aaf6fb95498ce988 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-07T22:46:07Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-eb23c0c0f3884653aaf6fb95498ce9882024-02-23T15:04:45ZengMDPI AGAnimals2076-26152024-02-0114458810.3390/ani14040588Clinicopathologic Characterization of Prostatic Cancer in DogsDemitria M. Vasilatis0Paramita M. Ghosh1Department of Urologic Surgery, School of Medicine, University of California Davis, Sacramento, CA 95718, USADepartment of Urologic Surgery, School of Medicine, University of California Davis, Sacramento, CA 95718, USAClinicopathologic data in dogs with prostate cancer (PCa) may aid in the differentiation between tumor types and subsequent treatment decisions; however, these data are often unreported. Demographic, clinicopathologic, cytologic, histologic and survival data from dogs with primary prostatic adenocarcinoma (PRAD) (<i>n</i> = 56) and primary prostatic transitional cell carcinoma (P-TCC) (<i>n</i> = 74) were acquired from a tertiary veterinary teaching hospital from 1992 to 2022. Red blood cell distribution width (RDW) to albumin ratio (RAR) was evaluated for diagnostic utility in differentiating between PRAD and P-TCC. Sections from PRAD tumors (<i>n</i> = 50) were stained for androgen receptor (AR) expression, and laboratory data were compared between AR positive (AR+) and AR negative (AR−) groups. RDW was increased in PRAD, while albumin was decreased (<i>p</i> < 0.05). P-TCC was associated with Melamed-Wolinska bodies (MWB) and necrosis on cytology (<i>p</i> < 0.05). RAR had acceptable diagnostic utility in the differentiation of PCa tumors (AUC = 0.7; <i>p</i> < 0.05). Survival rates and metastases were equivocal. AR+ and AR− PRAD tumors did not differ in clinicopathologic data or survival (<i>p</i> > 0.05). In conclusion, hypoalbuminemia was significantly associated with PRAD and decreased survival, while MWB and necrosis were significantly associated with P-TCC on cytology. These clinicopathologic data may help clinicians differentiate between these tumors ante mortem to guide appropriate treatment and intervention.https://www.mdpi.com/2076-2615/14/4/588clinical pathologycytologydogprostatic adenocarcinomared blood cell distribution widthred blood cell distribution width to albumin ratio |
| spellingShingle | Demitria M. Vasilatis Paramita M. Ghosh Clinicopathologic Characterization of Prostatic Cancer in Dogs Animals clinical pathology cytology dog prostatic adenocarcinoma red blood cell distribution width red blood cell distribution width to albumin ratio |
| title | Clinicopathologic Characterization of Prostatic Cancer in Dogs |
| title_full | Clinicopathologic Characterization of Prostatic Cancer in Dogs |
| title_fullStr | Clinicopathologic Characterization of Prostatic Cancer in Dogs |
| title_full_unstemmed | Clinicopathologic Characterization of Prostatic Cancer in Dogs |
| title_short | Clinicopathologic Characterization of Prostatic Cancer in Dogs |
| title_sort | clinicopathologic characterization of prostatic cancer in dogs |
| topic | clinical pathology cytology dog prostatic adenocarcinoma red blood cell distribution width red blood cell distribution width to albumin ratio |
| url | https://www.mdpi.com/2076-2615/14/4/588 |
| work_keys_str_mv | AT demitriamvasilatis clinicopathologiccharacterizationofprostaticcancerindogs AT paramitamghosh clinicopathologiccharacterizationofprostaticcancerindogs |