| Summary: | Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) is
an otologic emergency that can lead to loss of function in one of the most
important human senses. Recently, hyperbaric oxygen therapy (HBOT) has gained
popularity with pharmacotherapy in ISSNHL. This study aimed to determine
changes induced in thiol/disulfide homeostasis (TDH, a new biomarker of
systemic oxidative stress) by pharmacotherapy and HBOT in patients with ISSNHL.Methods: This prospective
study analyzed the albumin, total thiol, native thiol, and disulfide levels and
disulfide-native thiol, disulfide-total thiol, and native thiol-total thiol
ratios before and after HBOT with standardizing pharmacotherapy using a new
colorimetric method in patients
with ISSNHL.Results: 41 patients with
ISSNHL including 14 (34.1%) women and 27 (65.9%) men participated in the study.
The mean age of the patients was 48.02 ± 13.10 years. Of them, 24 (58.5%) had
hearing loss in the right ear and 17 (41.5%) had hearing loss in the left ear.
There was a statistically significant decrease in the albumin (p lt;0.001),
total thiol (p lt;0.001), native thiol (p lt;0.001), and disulfide (p lt;0.001)
levels after treatment compared to baseline. There was no statistically
significant difference in the disulfide-native thiol (p=0.148), disulfide-total
thiol (p=0.172), and native thiol-total thiol (p=0.169) ratios after treatment
compared to baseline.
Conclusion: Consequently,
this study demonstrated that the thiol-disulphide balance tended to shift
towards the oxidative side after HBOT and pharmacotherapy compared to baseline in patients with ISSNHL and
that patients with high oxidation level after treatment had better treatment
response.
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