Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss
Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) is an otologic emergency that can lead to loss of function in one of the most important human senses. Recently, hyperbaric oxygen therapy (HBOT) has gained popularity with pharmacotherapy in ISSNHL. This study aimed to determine cha...
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| Format: | Article |
| Language: | English |
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SERNEV
2018-10-01
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| Series: | Family Practice and Palliative Care |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/en/download/article-file/559943 |
| _version_ | 1797244669575299072 |
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| author | Cigdem Damla Cetinkaya Mehmet Ali Eryilmaz Salim Neselioglu Ruhusen Kutlu Abdullah Arslan İbrahim Solak Ozcan Erel Betul Kozanhan |
| author_facet | Cigdem Damla Cetinkaya Mehmet Ali Eryilmaz Salim Neselioglu Ruhusen Kutlu Abdullah Arslan İbrahim Solak Ozcan Erel Betul Kozanhan |
| author_sort | Cigdem Damla Cetinkaya |
| collection | DOAJ |
| description | Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) is
an otologic emergency that can lead to loss of function in one of the most
important human senses. Recently, hyperbaric oxygen therapy (HBOT) has gained
popularity with pharmacotherapy in ISSNHL. This study aimed to determine
changes induced in thiol/disulfide homeostasis (TDH, a new biomarker of
systemic oxidative stress) by pharmacotherapy and HBOT in patients with ISSNHL.Methods: This prospective
study analyzed the albumin, total thiol, native thiol, and disulfide levels and
disulfide-native thiol, disulfide-total thiol, and native thiol-total thiol
ratios before and after HBOT with standardizing pharmacotherapy using a new
colorimetric method in patients
with ISSNHL.Results: 41 patients with
ISSNHL including 14 (34.1%) women and 27 (65.9%) men participated in the study.
The mean age of the patients was 48.02 ± 13.10 years. Of them, 24 (58.5%) had
hearing loss in the right ear and 17 (41.5%) had hearing loss in the left ear.
There was a statistically significant decrease in the albumin (p lt;0.001),
total thiol (p lt;0.001), native thiol (p lt;0.001), and disulfide (p lt;0.001)
levels after treatment compared to baseline. There was no statistically
significant difference in the disulfide-native thiol (p=0.148), disulfide-total
thiol (p=0.172), and native thiol-total thiol (p=0.169) ratios after treatment
compared to baseline.
Conclusion: Consequently,
this study demonstrated that the thiol-disulphide balance tended to shift
towards the oxidative side after HBOT and pharmacotherapy compared to baseline in patients with ISSNHL and
that patients with high oxidation level after treatment had better treatment
response. |
| first_indexed | 2024-03-08T18:58:25Z |
| format | Article |
| id | doaj.art-eb23ce9019b94f7a9508f33c746aaef3 |
| institution | Directory Open Access Journal |
| issn | 2459-1505 |
| language | English |
| last_indexed | 2024-04-24T19:14:41Z |
| publishDate | 2018-10-01 |
| publisher | SERNEV |
| record_format | Article |
| series | Family Practice and Palliative Care |
| spelling | doaj.art-eb23ce9019b94f7a9508f33c746aaef32024-03-26T08:15:57ZengSERNEVFamily Practice and Palliative Care2459-15052018-10-013313313810.22391/fppc.470360544Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing lossCigdem Damla Cetinkaya0Mehmet Ali Eryilmaz1Salim Neselioglu2Ruhusen Kutlu3Abdullah Arslan4İbrahim Solak5Ozcan Erel6Betul Kozanhan7University of Health Sciences, Training and Research Hospital, Department of Biochemistry, KonyaUniversity of Health Sciences, Training and Research Hospital, Department of General Surgery, KonyaYildirim Beyazit University, Ankara Ataturk Training and Research Hospital, Department of Biochemistry, AnkaraNecmettin Erbakan University, School of Medicine, Department of Family Medicine, KonyaUniversity of Health Sciences, Training and Research Hospital, Department of Underwater and Hyperbaric, KonyaUniversity of Health Sciences, Training and Research Hospital, Department of Family Medicine, KonyaYildirim Beyazit University, Ankara Ataturk Training and Research Hospital, Department of Biochemistry, AnkaraUniversity of Health Sciences, Training and Research Hospital, Department of Anesthesiology, KonyaIntroduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) is an otologic emergency that can lead to loss of function in one of the most important human senses. Recently, hyperbaric oxygen therapy (HBOT) has gained popularity with pharmacotherapy in ISSNHL. This study aimed to determine changes induced in thiol/disulfide homeostasis (TDH, a new biomarker of systemic oxidative stress) by pharmacotherapy and HBOT in patients with ISSNHL.Methods: This prospective study analyzed the albumin, total thiol, native thiol, and disulfide levels and disulfide-native thiol, disulfide-total thiol, and native thiol-total thiol ratios before and after HBOT with standardizing pharmacotherapy using a new colorimetric method in patients with ISSNHL.Results: 41 patients with ISSNHL including 14 (34.1%) women and 27 (65.9%) men participated in the study. The mean age of the patients was 48.02 ± 13.10 years. Of them, 24 (58.5%) had hearing loss in the right ear and 17 (41.5%) had hearing loss in the left ear. There was a statistically significant decrease in the albumin (p lt;0.001), total thiol (p lt;0.001), native thiol (p lt;0.001), and disulfide (p lt;0.001) levels after treatment compared to baseline. There was no statistically significant difference in the disulfide-native thiol (p=0.148), disulfide-total thiol (p=0.172), and native thiol-total thiol (p=0.169) ratios after treatment compared to baseline. Conclusion: Consequently, this study demonstrated that the thiol-disulphide balance tended to shift towards the oxidative side after HBOT and pharmacotherapy compared to baseline in patients with ISSNHL and that patients with high oxidation level after treatment had better treatment response.https://dergipark.org.tr/en/download/article-file/559943idiopathic sudden sensorineural hearing lossoxidative stressthiol/disulfide homeostasishyperbaric oxygen therapyi̇diopatik ani sensorinöral işitme kaybıhiperbarik oksijen tedavisioksidatif strestiyol/disülfit homeostazisihiperbarik oksijen tedavisi |
| spellingShingle | Cigdem Damla Cetinkaya Mehmet Ali Eryilmaz Salim Neselioglu Ruhusen Kutlu Abdullah Arslan İbrahim Solak Ozcan Erel Betul Kozanhan Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss Family Practice and Palliative Care idiopathic sudden sensorineural hearing loss oxidative stress thiol/disulfide homeostasis hyperbaric oxygen therapy i̇diopatik ani sensorinöral işitme kaybı hiperbarik oksijen tedavisi oksidatif stres tiyol/disülfit homeostazisi hiperbarik oksijen tedavisi |
| title | Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss |
| title_full | Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss |
| title_fullStr | Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss |
| title_full_unstemmed | Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss |
| title_short | Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss |
| title_sort | effect of hyperbaric oxygen therapy on thiol disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss |
| topic | idiopathic sudden sensorineural hearing loss oxidative stress thiol/disulfide homeostasis hyperbaric oxygen therapy i̇diopatik ani sensorinöral işitme kaybı hiperbarik oksijen tedavisi oksidatif stres tiyol/disülfit homeostazisi hiperbarik oksijen tedavisi |
| url | https://dergipark.org.tr/en/download/article-file/559943 |
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