Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss
Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) isan otologic emergency that can lead to loss of function in one of the mostimportant human senses. Recently, hyperbaric oxygen therapy (HBOT) has gainedpopularity with pharmacotherapy in ISSNHL. This study aimed to determinechanges...
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SERNEV
2018-10-01
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| Series: | Family Practice and Palliative Care |
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| Online Access: | https://dergipark.org.tr/en/download/article-file/559943 |
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| author | Cigdem Damla Cetinkaya Mehmet Ali Eryilmaz Salim Neselioglu Ruhusen Kutlu Abdullah Arslan İbrahim Solak Ozcan Erel Betul Kozanhan |
| author_facet | Cigdem Damla Cetinkaya Mehmet Ali Eryilmaz Salim Neselioglu Ruhusen Kutlu Abdullah Arslan İbrahim Solak Ozcan Erel Betul Kozanhan |
| author_sort | Cigdem Damla Cetinkaya |
| collection | DOAJ |
| description | Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) isan otologic emergency that can lead to loss of function in one of the mostimportant human senses. Recently, hyperbaric oxygen therapy (HBOT) has gainedpopularity with pharmacotherapy in ISSNHL. This study aimed to determinechanges induced in thiol/disulfide homeostasis (TDH, a new biomarker ofsystemic oxidative stress) by pharmacotherapy and HBOT in patients with ISSNHL.Methods: This prospectivestudy analyzed the albumin, total thiol, native thiol, and disulfide levels anddisulfide-native thiol, disulfide-total thiol, and native thiol-total thiolratios before and after HBOT with standardizing pharmacotherapy using a newcolorimetric method in patientswith ISSNHL.Results: 41 patients withISSNHL including 14 (34.1%) women and 27 (65.9%) men participated in the study.The mean age of the patients was 48.02 ± 13.10 years. Of them, 24 (58.5%) hadhearing loss in the right ear and 17 (41.5%) had hearing loss in the left ear.There was a statistically significant decrease in the albumin (p lt;0.001),total thiol (p lt;0.001), native thiol (p lt;0.001), and disulfide (p lt;0.001)levels after treatment compared to baseline. There was no statisticallysignificant difference in the disulfide-native thiol (p=0.148), disulfide-totalthiol (p=0.172), and native thiol-total thiol (p=0.169) ratios after treatmentcompared to baseline.Conclusion: Consequently,this study demonstrated that the thiol-disulphide balance tended to shifttowards the oxidative side after HBOT and pharmacotherapy compared to baseline in patients with ISSNHL andthat patients with high oxidation level after treatment had better treatmentresponse. |
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| institution | Directory Open Access Journal |
| issn | 2459-1505 |
| language | English |
| last_indexed | 2025-02-18T08:10:49Z |
| publishDate | 2018-10-01 |
| publisher | SERNEV |
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| series | Family Practice and Palliative Care |
| spelling | doaj.art-eb23ce9019b94f7a9508f33c746aaef32024-11-04T07:54:17ZengSERNEVFamily Practice and Palliative Care2459-15052018-10-013313313810.22391/fppc.470360544Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing lossCigdem Damla Cetinkaya0https://orcid.org/0000-0002-6052-4645Mehmet Ali Eryilmaz1https://orcid.org/0000-0002-5280-3943Salim Neselioglu2https://orcid.org/0000-0001-7571-5949Ruhusen Kutlu3https://orcid.org/0000-0002-8502-0232Abdullah Arslan4https://orcid.org/0000-0001-5575-326Xİbrahim Solak5https://orcid.org/0000-0001-5311-0631Ozcan Erel6https://orcid.org/0000-0002-2483-1939Betul Kozanhan7https://orcid.org/0000-0002-5097-9291University of Health Sciences, Training and Research Hospital, Department of Biochemistry, KonyaUniversity of Health Sciences, Training and Research Hospital, Department of General Surgery, KonyaYildirim Beyazit University, Ankara Ataturk Training and Research Hospital, Department of Biochemistry, AnkaraNecmettin Erbakan University, School of Medicine, Department of Family Medicine, KonyaUniversity of Health Sciences, Training and Research Hospital, Department of Underwater and Hyperbaric, KonyaUniversity of Health Sciences, Training and Research Hospital, Department of Family Medicine, KonyaYildirim Beyazit University, Ankara Ataturk Training and Research Hospital, Department of Biochemistry, AnkaraUniversity of Health Sciences, Training and Research Hospital, Department of Anesthesiology, KonyaIntroduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) isan otologic emergency that can lead to loss of function in one of the mostimportant human senses. Recently, hyperbaric oxygen therapy (HBOT) has gainedpopularity with pharmacotherapy in ISSNHL. This study aimed to determinechanges induced in thiol/disulfide homeostasis (TDH, a new biomarker ofsystemic oxidative stress) by pharmacotherapy and HBOT in patients with ISSNHL.Methods: This prospectivestudy analyzed the albumin, total thiol, native thiol, and disulfide levels anddisulfide-native thiol, disulfide-total thiol, and native thiol-total thiolratios before and after HBOT with standardizing pharmacotherapy using a newcolorimetric method in patientswith ISSNHL.Results: 41 patients withISSNHL including 14 (34.1%) women and 27 (65.9%) men participated in the study.The mean age of the patients was 48.02 ± 13.10 years. Of them, 24 (58.5%) hadhearing loss in the right ear and 17 (41.5%) had hearing loss in the left ear.There was a statistically significant decrease in the albumin (p lt;0.001),total thiol (p lt;0.001), native thiol (p lt;0.001), and disulfide (p lt;0.001)levels after treatment compared to baseline. There was no statisticallysignificant difference in the disulfide-native thiol (p=0.148), disulfide-totalthiol (p=0.172), and native thiol-total thiol (p=0.169) ratios after treatmentcompared to baseline.Conclusion: Consequently,this study demonstrated that the thiol-disulphide balance tended to shifttowards the oxidative side after HBOT and pharmacotherapy compared to baseline in patients with ISSNHL andthat patients with high oxidation level after treatment had better treatmentresponse.https://dergipark.org.tr/en/download/article-file/559943idiopathic sudden sensorineural hearing lossoxidative stressthiol/disulfide homeostasishyperbaric oxygen therapyi̇diopatik ani sensorinöral işitme kaybıhiperbarik oksijen tedavisioksidatif strestiyol/disülfit homeostazisihiperbarik oksijen tedavisi |
| spellingShingle | Cigdem Damla Cetinkaya Mehmet Ali Eryilmaz Salim Neselioglu Ruhusen Kutlu Abdullah Arslan İbrahim Solak Ozcan Erel Betul Kozanhan Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss Family Practice and Palliative Care idiopathic sudden sensorineural hearing loss oxidative stress thiol/disulfide homeostasis hyperbaric oxygen therapy i̇diopatik ani sensorinöral işitme kaybı hiperbarik oksijen tedavisi oksidatif stres tiyol/disülfit homeostazisi hiperbarik oksijen tedavisi |
| title | Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss |
| title_full | Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss |
| title_fullStr | Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss |
| title_full_unstemmed | Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss |
| title_short | Effect of hyperbaric oxygen therapy on thiol/disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss |
| title_sort | effect of hyperbaric oxygen therapy on thiol disulfide homeostasis in patients with idiopathic sudden sensorineural hearing loss |
| topic | idiopathic sudden sensorineural hearing loss oxidative stress thiol/disulfide homeostasis hyperbaric oxygen therapy i̇diopatik ani sensorinöral işitme kaybı hiperbarik oksijen tedavisi oksidatif stres tiyol/disülfit homeostazisi hiperbarik oksijen tedavisi |
| url | https://dergipark.org.tr/en/download/article-file/559943 |
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