Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis
Breast cancer is the most common cancer in women and the second most common cancer overall. Although advancements in the early diagnosis and therapy of breast cancer have occurred in recent years, the prognosis of breast cancer bone metastasis remains poor and this type of cancer is rarely cured. Th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.894283/full |
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| author | Yu Wenhui Xie Zhongyu Chen Kai Cai Zhaopeng Li Jinteng Ma Mengjun Su Zepeng Che Yunshu Wang Peng Wu Yanfeng Shen Huiyong |
| author_facet | Yu Wenhui Xie Zhongyu Chen Kai Cai Zhaopeng Li Jinteng Ma Mengjun Su Zepeng Che Yunshu Wang Peng Wu Yanfeng Shen Huiyong |
| author_sort | Yu Wenhui |
| collection | DOAJ |
| description | Breast cancer is the most common cancer in women and the second most common cancer overall. Although advancements in the early diagnosis and therapy of breast cancer have occurred in recent years, the prognosis of breast cancer bone metastasis remains poor and this type of cancer is rarely cured. The gut microbiota is indispensable for internal homeostasis and regulates various biological processes. Understanding the gut microbiota profiles in normal controls (NCs), breast cancer patients with no metastasis (BNs), and breast cancer patients with bone metastasis (BMs) may shed light on the development of diagnostic and therapeutic targets for breast cancer and bone metastasis. We comprehensively analyzed the gut microbiota from NCs, BNs, and BMs and found that the community diversity decreased in the order of NCs, BNs, and BMs. Streptococcus, Campylobacter and Moraxellaceae showed higher abundances in BNs and BMs than in NCs. The lack of Megamonas and Akkermansia in the BM compared with those in the NC and BN groups was considered related to bone metastasis. Additionally, based on the distinct gut microbiota profiles, we predicted that lipid transportation and metabolism, as well as folate biosynthesis, participate in breast cancer occurrence and that steroid hormone biosynthesis influences bone metastasis. Our study demonstrated that variations in gut microbiota are associated with breast cancer occurrence and bone metastasis, providing attractive targets to develop therapeutic and diagnostic methods. |
| first_indexed | 2024-04-12T15:38:18Z |
| format | Article |
| id | doaj.art-eb25744a3420436eb0461d018e0d3723 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-12T15:38:18Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-eb25744a3420436eb0461d018e0d37232022-12-22T03:26:53ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-05-011310.3389/fmicb.2022.894283894283Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone MetastasisYu Wenhui0Xie Zhongyu1Chen Kai2Cai Zhaopeng3Li Jinteng4Ma Mengjun5Su Zepeng6Che Yunshu7Wang Peng8Wu Yanfeng9Shen Huiyong10Department of Orthopedics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaDepartment of Orthopedics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaBreast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Orthopedics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaDepartment of Orthopedics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaDepartment of Orthopedics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaDepartment of Orthopedics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaDepartment of Orthopedics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaDepartment of Orthopedics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaCenter for Biotherapy, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaDepartment of Orthopedics, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaBreast cancer is the most common cancer in women and the second most common cancer overall. Although advancements in the early diagnosis and therapy of breast cancer have occurred in recent years, the prognosis of breast cancer bone metastasis remains poor and this type of cancer is rarely cured. The gut microbiota is indispensable for internal homeostasis and regulates various biological processes. Understanding the gut microbiota profiles in normal controls (NCs), breast cancer patients with no metastasis (BNs), and breast cancer patients with bone metastasis (BMs) may shed light on the development of diagnostic and therapeutic targets for breast cancer and bone metastasis. We comprehensively analyzed the gut microbiota from NCs, BNs, and BMs and found that the community diversity decreased in the order of NCs, BNs, and BMs. Streptococcus, Campylobacter and Moraxellaceae showed higher abundances in BNs and BMs than in NCs. The lack of Megamonas and Akkermansia in the BM compared with those in the NC and BN groups was considered related to bone metastasis. Additionally, based on the distinct gut microbiota profiles, we predicted that lipid transportation and metabolism, as well as folate biosynthesis, participate in breast cancer occurrence and that steroid hormone biosynthesis influences bone metastasis. Our study demonstrated that variations in gut microbiota are associated with breast cancer occurrence and bone metastasis, providing attractive targets to develop therapeutic and diagnostic methods.https://www.frontiersin.org/articles/10.3389/fmicb.2022.894283/fullgut microbiotabone metastasis (BM)breast cancer neoadjuvant therapy16S rRNA sequencingPICRUSt (functional genes) |
| spellingShingle | Yu Wenhui Xie Zhongyu Chen Kai Cai Zhaopeng Li Jinteng Ma Mengjun Su Zepeng Che Yunshu Wang Peng Wu Yanfeng Shen Huiyong Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis Frontiers in Microbiology gut microbiota bone metastasis (BM) breast cancer neoadjuvant therapy 16S rRNA sequencing PICRUSt (functional genes) |
| title | Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis |
| title_full | Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis |
| title_fullStr | Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis |
| title_full_unstemmed | Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis |
| title_short | Variations in the Gut Microbiota in Breast Cancer Occurrence and Bone Metastasis |
| title_sort | variations in the gut microbiota in breast cancer occurrence and bone metastasis |
| topic | gut microbiota bone metastasis (BM) breast cancer neoadjuvant therapy 16S rRNA sequencing PICRUSt (functional genes) |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.894283/full |
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