Echocardiography and N-terminal-pro-brain natriuretic peptide in assessment of left ventricular diastolic dysfunction in stable COPD in relation to disease severity
Introduction: Left ventricular diastolic dysfunction (LVDD) is found to be frequent in COPD patients. Relationship between airflow obstruction and cardiovascular risk can be explained by inflammation which is considered one of systemic manifestations of COPD. Objective: To assess the LVDD in COPD pa...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0422763816302667 |
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| author | Gehan H. AboEl-Magd Timoor Hassan Mohamed H. Aly Maaly M. Mabrouk |
| author_facet | Gehan H. AboEl-Magd Timoor Hassan Mohamed H. Aly Maaly M. Mabrouk |
| author_sort | Gehan H. AboEl-Magd |
| collection | DOAJ |
| description | Introduction: Left ventricular diastolic dysfunction (LVDD) is found to be frequent in COPD patients. Relationship between airflow obstruction and cardiovascular risk can be explained by inflammation which is considered one of systemic manifestations of COPD.
Objective: To assess the LVDD in COPD patients in relation to disease severity using echocardiography, N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high sensitive C-reactive protein (hs-CRP).
Patients and methods: This prospective study was carried out on 60 stable COPD patients who were recruited from outpatient chest clinics, Tanta University Hospitals. Diagnosis of COPD was made according to criteria of the Global Initiative for Chronic Obstructive Lung Disease. Patients were subjected to medical history and physical examination, chest X ray, pulmonary functions, ECG and echocardiography. Blood samples were withdrawn for assessment of NT-proBNP and hs-CRP.
Results: Diastolic function of the heart was evaluated by echocardiography using: isovolumetric relaxation time (IVRT), deceleration time of early transmitral flow, ratio of the peak velocity of the early E wave/A wave which suggested that LVDD was recorded more in severe/very severe compared to mild/moderate COPD. Significant positive correlations were found between Nt-pro BNP and hs-CRP, IVRT, deceleration time of early transmitral flow and E/A wave ratio. Sensitivity, specificity and accuracy were 83.1, 90 and 0.94% for Nt-pro BNP.
Conclusions: Evaluation of NT-proBNP was important for detection of LVDD in COPD patients, which was correlated with disease severity. Echocardiographic assessment of COPD patients, especially in combination with NT-proBNP can be considered as good diagnostic tools of LVDD in COPD. |
| first_indexed | 2024-12-19T22:56:24Z |
| format | Article |
| id | doaj.art-eb2760ffca784e22afefdc2e45f1edc5 |
| institution | Directory Open Access Journal |
| issn | 0422-7638 |
| language | English |
| last_indexed | 2024-12-19T22:56:24Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj.art-eb2760ffca784e22afefdc2e45f1edc52022-12-21T20:02:38ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382017-01-01661758010.1016/j.ejcdt.2016.12.007Echocardiography and N-terminal-pro-brain natriuretic peptide in assessment of left ventricular diastolic dysfunction in stable COPD in relation to disease severityGehan H. AboEl-Magd0Timoor Hassan1Mohamed H. Aly2Maaly M. Mabrouk3Chest Diseases Department, Faculty of Medicine, Tanta University, EgyptCardiology Department, Faculty of Medicine, Tanta University, EgyptInternal Medicine Department, Qena Faculty of Medicine, South Valley University, EgyptClinical Pathology Department, Faculty of Medicine, Tanta University, EgyptIntroduction: Left ventricular diastolic dysfunction (LVDD) is found to be frequent in COPD patients. Relationship between airflow obstruction and cardiovascular risk can be explained by inflammation which is considered one of systemic manifestations of COPD. Objective: To assess the LVDD in COPD patients in relation to disease severity using echocardiography, N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high sensitive C-reactive protein (hs-CRP). Patients and methods: This prospective study was carried out on 60 stable COPD patients who were recruited from outpatient chest clinics, Tanta University Hospitals. Diagnosis of COPD was made according to criteria of the Global Initiative for Chronic Obstructive Lung Disease. Patients were subjected to medical history and physical examination, chest X ray, pulmonary functions, ECG and echocardiography. Blood samples were withdrawn for assessment of NT-proBNP and hs-CRP. Results: Diastolic function of the heart was evaluated by echocardiography using: isovolumetric relaxation time (IVRT), deceleration time of early transmitral flow, ratio of the peak velocity of the early E wave/A wave which suggested that LVDD was recorded more in severe/very severe compared to mild/moderate COPD. Significant positive correlations were found between Nt-pro BNP and hs-CRP, IVRT, deceleration time of early transmitral flow and E/A wave ratio. Sensitivity, specificity and accuracy were 83.1, 90 and 0.94% for Nt-pro BNP. Conclusions: Evaluation of NT-proBNP was important for detection of LVDD in COPD patients, which was correlated with disease severity. Echocardiographic assessment of COPD patients, especially in combination with NT-proBNP can be considered as good diagnostic tools of LVDD in COPD.http://www.sciencedirect.com/science/article/pii/S0422763816302667COPDLeft ventricular diastolic dysfunctionNT-proBNPhs-CRPEchocardiography |
| spellingShingle | Gehan H. AboEl-Magd Timoor Hassan Mohamed H. Aly Maaly M. Mabrouk Echocardiography and N-terminal-pro-brain natriuretic peptide in assessment of left ventricular diastolic dysfunction in stable COPD in relation to disease severity Egyptian Journal of Chest Disease and Tuberculosis COPD Left ventricular diastolic dysfunction NT-proBNP hs-CRP Echocardiography |
| title | Echocardiography and N-terminal-pro-brain natriuretic peptide in assessment of left ventricular diastolic dysfunction in stable COPD in relation to disease severity |
| title_full | Echocardiography and N-terminal-pro-brain natriuretic peptide in assessment of left ventricular diastolic dysfunction in stable COPD in relation to disease severity |
| title_fullStr | Echocardiography and N-terminal-pro-brain natriuretic peptide in assessment of left ventricular diastolic dysfunction in stable COPD in relation to disease severity |
| title_full_unstemmed | Echocardiography and N-terminal-pro-brain natriuretic peptide in assessment of left ventricular diastolic dysfunction in stable COPD in relation to disease severity |
| title_short | Echocardiography and N-terminal-pro-brain natriuretic peptide in assessment of left ventricular diastolic dysfunction in stable COPD in relation to disease severity |
| title_sort | echocardiography and n terminal pro brain natriuretic peptide in assessment of left ventricular diastolic dysfunction in stable copd in relation to disease severity |
| topic | COPD Left ventricular diastolic dysfunction NT-proBNP hs-CRP Echocardiography |
| url | http://www.sciencedirect.com/science/article/pii/S0422763816302667 |
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