Reactivating a positive feedback loop VTA-BLA-NAc circuit associated with positive experience ameliorates the attenuated reward sensitivity induced by chronic stress

Reactivating a positive feedback loop VTA-BLA-NAc circuit associated with positive experience ameliorates the attenuated reward sensitivity induced by chronic stress

Both genetic predisposition and life events, particularly life stress, are thought to increase the risk for depression. Reward sensitivity appears to be attenuated in major depressive disorder (MDD), suggesting deficits in reward processing in these patients. We identified the VTA-BLA-NAc circuit as...

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Bibliographic Details
Main Authors: Linshan Sun, Jingjing You, Fengjiao Sun, Minghu Cui, Jiangong Wang, Wentao Wang, Dan Wang, Dunjiang Liu, Zhicheng Xu, Changyun Qiu, Bin Liu, Haijing Yan
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Neurobiology of Stress
Subjects:
Reward insensitivity
Chronic stress
VTA-BLA-NAc circuit
Positive feedback loop
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289521000783

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