Separation of 103Ru from a proton irradiated thorium matrix: A potential source of Auger therapy radionuclide 103mRh.
Ruthenium-103 is the parent isotope of 103mRh (t1/2 56.1 min), an isotope of interest for Auger electron therapy. During the proton irradiation of thorium targets, large amounts of 103Ru are generated through proton induced fission. The development of a two part chemical separation process to isolat...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5741265?pdf=render |
| _version_ | 1828337493652537344 |
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| author | Tara Mastren Valery Radchenko Philip D Hopkins Jonathan W Engle John W Weidner Roy Copping Mark Brugh F Meiring Nortier Eva R Birnbaum Kevin D John Michael Ernst-Heinrich Fassbender |
| author_facet | Tara Mastren Valery Radchenko Philip D Hopkins Jonathan W Engle John W Weidner Roy Copping Mark Brugh F Meiring Nortier Eva R Birnbaum Kevin D John Michael Ernst-Heinrich Fassbender |
| author_sort | Tara Mastren |
| collection | DOAJ |
| description | Ruthenium-103 is the parent isotope of 103mRh (t1/2 56.1 min), an isotope of interest for Auger electron therapy. During the proton irradiation of thorium targets, large amounts of 103Ru are generated through proton induced fission. The development of a two part chemical separation process to isolate 103Ru in high yield and purity from a proton irradiated thorium matrix on an analytical scale is described herein. The first part employed an anion exchange column to remove cationic actinide/lanthanide impurities along with the majority of the transition metal fission products. Secondly, an extraction chromatographic column utilizing diglycolamide functional groups was used to decontaminate 103Ru from the remaining impurities. This method resulted in a final radiochemical yield of 83 ± 5% of 103Ru with a purity of 99.9%. Additionally, measured nuclear reaction cross sections for the formation of 103Ru and 106Ru via the 232Th(p,f)103,106Ru reactions are reported within. |
| first_indexed | 2024-04-13T22:16:01Z |
| format | Article |
| id | doaj.art-eb2b44ace77b4b0190e5973af9c40b82 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T22:16:01Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-eb2b44ace77b4b0190e5973af9c40b822022-12-22T02:27:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011212e019030810.1371/journal.pone.0190308Separation of 103Ru from a proton irradiated thorium matrix: A potential source of Auger therapy radionuclide 103mRh.Tara MastrenValery RadchenkoPhilip D HopkinsJonathan W EngleJohn W WeidnerRoy CoppingMark BrughF Meiring NortierEva R BirnbaumKevin D JohnMichael Ernst-Heinrich FassbenderRuthenium-103 is the parent isotope of 103mRh (t1/2 56.1 min), an isotope of interest for Auger electron therapy. During the proton irradiation of thorium targets, large amounts of 103Ru are generated through proton induced fission. The development of a two part chemical separation process to isolate 103Ru in high yield and purity from a proton irradiated thorium matrix on an analytical scale is described herein. The first part employed an anion exchange column to remove cationic actinide/lanthanide impurities along with the majority of the transition metal fission products. Secondly, an extraction chromatographic column utilizing diglycolamide functional groups was used to decontaminate 103Ru from the remaining impurities. This method resulted in a final radiochemical yield of 83 ± 5% of 103Ru with a purity of 99.9%. Additionally, measured nuclear reaction cross sections for the formation of 103Ru and 106Ru via the 232Th(p,f)103,106Ru reactions are reported within.http://europepmc.org/articles/PMC5741265?pdf=render |
| spellingShingle | Tara Mastren Valery Radchenko Philip D Hopkins Jonathan W Engle John W Weidner Roy Copping Mark Brugh F Meiring Nortier Eva R Birnbaum Kevin D John Michael Ernst-Heinrich Fassbender Separation of 103Ru from a proton irradiated thorium matrix: A potential source of Auger therapy radionuclide 103mRh. PLoS ONE |
| title | Separation of 103Ru from a proton irradiated thorium matrix: A potential source of Auger therapy radionuclide 103mRh. |
| title_full | Separation of 103Ru from a proton irradiated thorium matrix: A potential source of Auger therapy radionuclide 103mRh. |
| title_fullStr | Separation of 103Ru from a proton irradiated thorium matrix: A potential source of Auger therapy radionuclide 103mRh. |
| title_full_unstemmed | Separation of 103Ru from a proton irradiated thorium matrix: A potential source of Auger therapy radionuclide 103mRh. |
| title_short | Separation of 103Ru from a proton irradiated thorium matrix: A potential source of Auger therapy radionuclide 103mRh. |
| title_sort | separation of 103ru from a proton irradiated thorium matrix a potential source of auger therapy radionuclide 103mrh |
| url | http://europepmc.org/articles/PMC5741265?pdf=render |
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