The Genetic Regulation of Aortic Valve Development and Calcific Disease

The Genetic Regulation of Aortic Valve Development and Calcific Disease

Heart valves are dynamic, highly organized structures required for unidirectional blood flow through the heart. Over an average lifetime, the valve leaflets or cusps open and close over a billion times, however in over 5 million Americans, leaflet function fails due to biomechanical insufficiency in...

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Bibliographic Details
Main Authors:	Vinal Menon, Joy Lincoln
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-11-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	aortic valve calcification extracellular matrix valve interstitial cell valve endothelial cell hemodynamics epigenetics
Online Access:	https://www.frontiersin.org/article/10.3389/fcvm.2018.00162/full

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