Cardioprotective Effects of : A Review of Bioactive Extracts and Compounds
There has been accumulating interest in the application of medicinal plants as alternative medicine to treat various diseases and/or to develop modern medicines. Vitex negundo is one of such medicinal plants that has been of interest to many researchers and has been of use in traditional medicine ....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-05-01
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| Series: | Journal of Evidence-Based Integrative Medicine |
| Online Access: | https://doi.org/10.1177/2515690X231176622 |
| _version_ | 1797809745240784896 |
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| author | Boniface Nyamweya BSc, MSc Dilani Rukshala BSc, MSc Narmada Fernando PhD Rajiva de Silva MBBS, MD Sunil Premawansa PhD Shiroma Handunnetti PhD |
| author_facet | Boniface Nyamweya BSc, MSc Dilani Rukshala BSc, MSc Narmada Fernando PhD Rajiva de Silva MBBS, MD Sunil Premawansa PhD Shiroma Handunnetti PhD |
| author_sort | Boniface Nyamweya BSc, MSc |
| collection | DOAJ |
| description | There has been accumulating interest in the application of medicinal plants as alternative medicine to treat various diseases and/or to develop modern medicines. Vitex negundo is one of such medicinal plants that has been of interest to many researchers and has been of use in traditional medicine . V. negundo is found in Sri Lanka, Madagascar, Malaysia, India, China, The Philippines and East Africa. Therapeutic properties of V. negundo have previously been reviewed. Different parts, preparations and bioactive components of V. negundo possess potential protective and therapeutic effects against cardiovascular disease and related conditions as demonstrated in previous studies. We review the present state of scientific knowledge on the potential use of V. negundo and some of its bioactive components in protecting against cardiovascular diseases and related pathologies. Previous studies in animal and non-animal experimental models, although limited in number and vary in design, seem to support the cardioprotective effect of V. negundo and some of its active components. However, there is need for further preclinical and clinical studies to validate the use of V. negundo and its active constituents in protection and treatment of cardiovascular diseases. Additionally, since only a few V. negundo compounds have been evaluated, specific cardioprotective effects or mechanisms and possible side effects of other V. negundo compounds need to be extensively evaluated. |
| first_indexed | 2024-03-13T06:57:23Z |
| format | Article |
| id | doaj.art-eb2d7c31ff424d76bf908d19c8eebbe5 |
| institution | Directory Open Access Journal |
| issn | 2515-690X |
| language | English |
| last_indexed | 2024-03-13T06:57:23Z |
| publishDate | 2023-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Evidence-Based Integrative Medicine |
| spelling | doaj.art-eb2d7c31ff424d76bf908d19c8eebbe52023-06-07T05:33:24ZengSAGE PublishingJournal of Evidence-Based Integrative Medicine2515-690X2023-05-012810.1177/2515690X231176622Cardioprotective Effects of : A Review of Bioactive Extracts and CompoundsBoniface Nyamweya BSc, MSc0Dilani Rukshala BSc, MSc1Narmada Fernando PhD2Rajiva de Silva MBBS, MD3Sunil Premawansa PhD4Shiroma Handunnetti PhD5 Institute of Biochemistry, Molecular Biology and Biotechnology, , Colombo 03, Sri Lanka Institute of Biochemistry, Molecular Biology and Biotechnology, , Colombo 03, Sri Lanka Institute of Biochemistry, Molecular Biology and Biotechnology, , Colombo 03, Sri Lanka Department of Immunology, Medical Research Institute, Colombo 08, Sri Lanka Departments of Zoology and Environment Sciences, , Colombo 03, Sri Lanka Institute of Biochemistry, Molecular Biology and Biotechnology, , Colombo 03, Sri LankaThere has been accumulating interest in the application of medicinal plants as alternative medicine to treat various diseases and/or to develop modern medicines. Vitex negundo is one of such medicinal plants that has been of interest to many researchers and has been of use in traditional medicine . V. negundo is found in Sri Lanka, Madagascar, Malaysia, India, China, The Philippines and East Africa. Therapeutic properties of V. negundo have previously been reviewed. Different parts, preparations and bioactive components of V. negundo possess potential protective and therapeutic effects against cardiovascular disease and related conditions as demonstrated in previous studies. We review the present state of scientific knowledge on the potential use of V. negundo and some of its bioactive components in protecting against cardiovascular diseases and related pathologies. Previous studies in animal and non-animal experimental models, although limited in number and vary in design, seem to support the cardioprotective effect of V. negundo and some of its active components. However, there is need for further preclinical and clinical studies to validate the use of V. negundo and its active constituents in protection and treatment of cardiovascular diseases. Additionally, since only a few V. negundo compounds have been evaluated, specific cardioprotective effects or mechanisms and possible side effects of other V. negundo compounds need to be extensively evaluated.https://doi.org/10.1177/2515690X231176622 |
| spellingShingle | Boniface Nyamweya BSc, MSc Dilani Rukshala BSc, MSc Narmada Fernando PhD Rajiva de Silva MBBS, MD Sunil Premawansa PhD Shiroma Handunnetti PhD Cardioprotective Effects of : A Review of Bioactive Extracts and Compounds Journal of Evidence-Based Integrative Medicine |
| title | Cardioprotective Effects of : A Review of Bioactive Extracts and Compounds |
| title_full | Cardioprotective Effects of : A Review of Bioactive Extracts and Compounds |
| title_fullStr | Cardioprotective Effects of : A Review of Bioactive Extracts and Compounds |
| title_full_unstemmed | Cardioprotective Effects of : A Review of Bioactive Extracts and Compounds |
| title_short | Cardioprotective Effects of : A Review of Bioactive Extracts and Compounds |
| title_sort | cardioprotective effects of a review of bioactive extracts and compounds |
| url | https://doi.org/10.1177/2515690X231176622 |
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