Clinical research of drug-coated balloon after rotational atherectomy for severe coronary artery calcification
Abstract Background Current research results show that drug-coated balloons (DCB) have unique advantages in the treatment of in-stent restenosis, small vessel disease, bifurcation lesions, and de novo lesions, but the data regarding rotational atherectomy (RA) followed by DCB treatment in calcified...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-023-03071-8 |
| _version_ | 1797946124147884032 |
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| author | Haozhe Dong Yingguang Shan Shenzhen Gong Ran Li Yiming Li Xupeng Lu Guoju Sun |
| author_facet | Haozhe Dong Yingguang Shan Shenzhen Gong Ran Li Yiming Li Xupeng Lu Guoju Sun |
| author_sort | Haozhe Dong |
| collection | DOAJ |
| description | Abstract Background Current research results show that drug-coated balloons (DCB) have unique advantages in the treatment of in-stent restenosis, small vessel disease, bifurcation lesions, and de novo lesions, but the data regarding rotational atherectomy (RA) followed by DCB treatment in calcified lesions, especially severe coronary artery calcification (CAC), are limited. Methods A retrospective study was conducted on 318 individuals with severe CAC who underwent RA-assisted PCI at the First Affiliated Hospital of Zhengzhou University from May 2018 to July 2021. Among them, 57 patients (RA/DCB group) were treated with DCB, and 261 patients (RA/DES group) were treated with drug-eluting stents (DES). The two groups' clinical baseline data, lesion characteristics, intraoperative complications, in-hospital adverse events, and major adverse cardiovascular and cerebrovascular events (MACCE) were compared throughout the follow-up period. Results The baseline clinical data, intraoperative complications, and in-hospital adverse events were not significantly different between the two groups. The anatomical categories in the RA/DES group were more complex and included left main coronary disease, bifurcation disease, and multivessel disease. Although target lesion revascularization (13.79% vs. 7.02%) and MACCE (18.77% vs. 12.28%) occurred more frequently in the RA/DES group than in the RA/DCB group, there was no statistically significant difference (p > 0.05). Multivariate Cox regression analysis showed that bifurcation lesions (HR 2.284, 95% CI 1.063–4.908, p = 0.034), total length of DCB/DES (HR 1.023, 95% CI 1.005–1.047, p = 0.014) and SYNTAX score (HR 1.047, 95% CI 1.013–1.082, p = 0.006) were independent risk factors for MACCE during the follow-up period. Conclusion Drug-coated balloon treatment after rotational atherectomy appears safe and effective in selected severe coronary artery calcification. |
| first_indexed | 2024-04-10T21:05:56Z |
| format | Article |
| id | doaj.art-eb2fa14c960041f9ab54792c08727d46 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-10T21:05:56Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-eb2fa14c960041f9ab54792c08727d462023-01-22T12:04:09ZengBMCBMC Cardiovascular Disorders1471-22612023-01-012311810.1186/s12872-023-03071-8Clinical research of drug-coated balloon after rotational atherectomy for severe coronary artery calcificationHaozhe Dong0Yingguang Shan1Shenzhen Gong2Ran Li3Yiming Li4Xupeng Lu5Guoju Sun6Department of Cardiovascular Medicine, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Zhengzhou UniversityAbstract Background Current research results show that drug-coated balloons (DCB) have unique advantages in the treatment of in-stent restenosis, small vessel disease, bifurcation lesions, and de novo lesions, but the data regarding rotational atherectomy (RA) followed by DCB treatment in calcified lesions, especially severe coronary artery calcification (CAC), are limited. Methods A retrospective study was conducted on 318 individuals with severe CAC who underwent RA-assisted PCI at the First Affiliated Hospital of Zhengzhou University from May 2018 to July 2021. Among them, 57 patients (RA/DCB group) were treated with DCB, and 261 patients (RA/DES group) were treated with drug-eluting stents (DES). The two groups' clinical baseline data, lesion characteristics, intraoperative complications, in-hospital adverse events, and major adverse cardiovascular and cerebrovascular events (MACCE) were compared throughout the follow-up period. Results The baseline clinical data, intraoperative complications, and in-hospital adverse events were not significantly different between the two groups. The anatomical categories in the RA/DES group were more complex and included left main coronary disease, bifurcation disease, and multivessel disease. Although target lesion revascularization (13.79% vs. 7.02%) and MACCE (18.77% vs. 12.28%) occurred more frequently in the RA/DES group than in the RA/DCB group, there was no statistically significant difference (p > 0.05). Multivariate Cox regression analysis showed that bifurcation lesions (HR 2.284, 95% CI 1.063–4.908, p = 0.034), total length of DCB/DES (HR 1.023, 95% CI 1.005–1.047, p = 0.014) and SYNTAX score (HR 1.047, 95% CI 1.013–1.082, p = 0.006) were independent risk factors for MACCE during the follow-up period. Conclusion Drug-coated balloon treatment after rotational atherectomy appears safe and effective in selected severe coronary artery calcification.https://doi.org/10.1186/s12872-023-03071-8Drug-coated balloonCoronary calcified calcificationRotational atherectomyDrug-eluting stent |
| spellingShingle | Haozhe Dong Yingguang Shan Shenzhen Gong Ran Li Yiming Li Xupeng Lu Guoju Sun Clinical research of drug-coated balloon after rotational atherectomy for severe coronary artery calcification BMC Cardiovascular Disorders Drug-coated balloon Coronary calcified calcification Rotational atherectomy Drug-eluting stent |
| title | Clinical research of drug-coated balloon after rotational atherectomy for severe coronary artery calcification |
| title_full | Clinical research of drug-coated balloon after rotational atherectomy for severe coronary artery calcification |
| title_fullStr | Clinical research of drug-coated balloon after rotational atherectomy for severe coronary artery calcification |
| title_full_unstemmed | Clinical research of drug-coated balloon after rotational atherectomy for severe coronary artery calcification |
| title_short | Clinical research of drug-coated balloon after rotational atherectomy for severe coronary artery calcification |
| title_sort | clinical research of drug coated balloon after rotational atherectomy for severe coronary artery calcification |
| topic | Drug-coated balloon Coronary calcified calcification Rotational atherectomy Drug-eluting stent |
| url | https://doi.org/10.1186/s12872-023-03071-8 |
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