Human leukocyte antigen-associated uveitis in Thai population: Brief review
Human Leukocyte Antigen (HLA) has been associated with several immune-mediated diseases, malignancies and infectious diseases. Due to the HLA complexity and polymorphisms, several types of HLA have been used as the molecular markers in diagnosis. Among different ethnic groups, HLA is genetically div...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Chaing Mai University
2015-01-01
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| Series: | Journal of Associated Medical Sciences |
| Subjects: | |
| Online Access: | https://www.tci-thaijo.org/index.php/bulletinAMS/article/view/59949 |
| _version_ | 1817995546626883584 |
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| author | Nampeung Anukul Nipapan Leetrakool Kessara Pathanapitoon |
| author_facet | Nampeung Anukul Nipapan Leetrakool Kessara Pathanapitoon |
| author_sort | Nampeung Anukul |
| collection | DOAJ |
| description | Human Leukocyte Antigen (HLA) has been associated with several immune-mediated diseases,
malignancies and infectious diseases. Due to the HLA complexity and polymorphisms, several types
of HLA have been used as the molecular markers in diagnosis. Among different ethnic groups, HLA is
genetically diverse resulting in the differences of disease susceptibility. The study of HLA in Thai population
will help an understanding of diseases pathogenesis and the genetic linkage leading to the development
of genetic markers that are specific to Thai population. Vogt-Koyanagi-Harada (VKH) syndrome,
HLA-B27-associated acute anterior uveitis (AAU) and Behçet’s disease (BD) were found to be the major
causes of non-infectious and autoimmune-related uveitis in Thai patients. Several etiologic studies in
Western, European and other Asian populations reported the strong association between HLA-DR4 and
VKH, HLA-B27 and AAU as well as HLA-B51 and BD. However, few in HLA-B27 and none in HLA-B51 and
HLA-DR4 related uveitis study have been reported in Thailand. This briefly review discusses the association
of HLA and non-infectious uveitis among populations and future research aspects for Thai populations.
Bull Chiang Mai Assoc Med Sci 2015; 48(1): 10-17. Doi: 10.14456/jams.2015.6 |
| first_indexed | 2024-04-14T02:07:32Z |
| format | Article |
| id | doaj.art-eb322d6ee79d48d1b9f1ba334205d43e |
| institution | Directory Open Access Journal |
| issn | 2539-6056 2539-6056 |
| language | English |
| last_indexed | 2024-04-14T02:07:32Z |
| publishDate | 2015-01-01 |
| publisher | Chaing Mai University |
| record_format | Article |
| series | Journal of Associated Medical Sciences |
| spelling | doaj.art-eb322d6ee79d48d1b9f1ba334205d43e2022-12-22T02:18:37ZengChaing Mai UniversityJournal of Associated Medical Sciences2539-60562539-60562015-01-01481101059949Human leukocyte antigen-associated uveitis in Thai population: Brief reviewNampeung Anukul0Nipapan Leetrakool1Kessara Pathanapitoon21 Division of Transfusion Sciences, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University 2 HLA Laboratory, Blood Bank Section, Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Chiang Mai University 3 Department of Ophthalmology, Faculty of Medicine, Chiang Mai University1 Division of Transfusion Sciences, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University 2 HLA Laboratory, Blood Bank Section, Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Chiang Mai University 3 Department of Ophthalmology, Faculty of Medicine, Chiang Mai University1 Division of Transfusion Sciences, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University 2 HLA Laboratory, Blood Bank Section, Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Chiang Mai University 3 Department of Ophthalmology, Faculty of Medicine, Chiang Mai UniversityHuman Leukocyte Antigen (HLA) has been associated with several immune-mediated diseases, malignancies and infectious diseases. Due to the HLA complexity and polymorphisms, several types of HLA have been used as the molecular markers in diagnosis. Among different ethnic groups, HLA is genetically diverse resulting in the differences of disease susceptibility. The study of HLA in Thai population will help an understanding of diseases pathogenesis and the genetic linkage leading to the development of genetic markers that are specific to Thai population. Vogt-Koyanagi-Harada (VKH) syndrome, HLA-B27-associated acute anterior uveitis (AAU) and Behçet’s disease (BD) were found to be the major causes of non-infectious and autoimmune-related uveitis in Thai patients. Several etiologic studies in Western, European and other Asian populations reported the strong association between HLA-DR4 and VKH, HLA-B27 and AAU as well as HLA-B51 and BD. However, few in HLA-B27 and none in HLA-B51 and HLA-DR4 related uveitis study have been reported in Thailand. This briefly review discusses the association of HLA and non-infectious uveitis among populations and future research aspects for Thai populations. Bull Chiang Mai Assoc Med Sci 2015; 48(1): 10-17. Doi: 10.14456/jams.2015.6https://www.tci-thaijo.org/index.php/bulletinAMS/article/view/59949Human leukocyte antigenHLAuveitisdisease association |
| spellingShingle | Nampeung Anukul Nipapan Leetrakool Kessara Pathanapitoon Human leukocyte antigen-associated uveitis in Thai population: Brief review Journal of Associated Medical Sciences Human leukocyte antigen HLA uveitis disease association |
| title | Human leukocyte antigen-associated uveitis in Thai population: Brief review |
| title_full | Human leukocyte antigen-associated uveitis in Thai population: Brief review |
| title_fullStr | Human leukocyte antigen-associated uveitis in Thai population: Brief review |
| title_full_unstemmed | Human leukocyte antigen-associated uveitis in Thai population: Brief review |
| title_short | Human leukocyte antigen-associated uveitis in Thai population: Brief review |
| title_sort | human leukocyte antigen associated uveitis in thai population brief review |
| topic | Human leukocyte antigen HLA uveitis disease association |
| url | https://www.tci-thaijo.org/index.php/bulletinAMS/article/view/59949 |
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