Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application
N4 macrocyclic complexes of Al and Zn phthalocyanines with symmetrical imine and imidazole moiety at the periphery were synthesized. The synthesized ligands, complexes, and polymers were purified and characterized to study the structure of the molecule. These synthesized complexes were used for phot...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2021.647331/full |
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| author | Keshavananda Prabhu C. P. Manjunatha Nemakal Muthumuni Managa Tebello Nyokong Lokesh Koodlur Sannegowda |
| author_facet | Keshavananda Prabhu C. P. Manjunatha Nemakal Muthumuni Managa Tebello Nyokong Lokesh Koodlur Sannegowda |
| author_sort | Keshavananda Prabhu C. P. |
| collection | DOAJ |
| description | N4 macrocyclic complexes of Al and Zn phthalocyanines with symmetrical imine and imidazole moiety at the periphery were synthesized. The synthesized ligands, complexes, and polymers were purified and characterized to study the structure of the molecule. These synthesized complexes were used for photodynamic therapy application as the diamagnetic Zn and Al have the ability to produce and stabilize singlet oxygen species. The synthesized N4 molecules of aluminum iminomethoxy phenyl phthalocyanine and aluminum ethyl phenyl benzimidazolephthalocyanine showed better activity against MCF-7 cells. These results suggest that this assay may be used as an early biomarker of clinical response. |
| first_indexed | 2024-12-19T10:12:34Z |
| format | Article |
| id | doaj.art-eb34cc9581e44c2da247c01d0969178a |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-12-19T10:12:34Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-eb34cc9581e44c2da247c01d0969178a2022-12-21T20:26:20ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-06-01910.3389/fchem.2021.647331647331Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy ApplicationKeshavananda Prabhu C. P.0Manjunatha Nemakal1Muthumuni Managa2Tebello Nyokong3Lokesh Koodlur Sannegowda4Department of Studies in Chemistry, Vijayanagara Sri Krishnadevaraya University, Ballari, IndiaDepartment of Studies in Chemistry, Vijayanagara Sri Krishnadevaraya University, Ballari, IndiaDepartment of Chemistry, Institute for Nanotechnology Innovation, Rhodes University, Makhanda, South AfricaDepartment of Chemistry, Institute for Nanotechnology Innovation, Rhodes University, Makhanda, South AfricaDepartment of Studies in Chemistry, Vijayanagara Sri Krishnadevaraya University, Ballari, IndiaN4 macrocyclic complexes of Al and Zn phthalocyanines with symmetrical imine and imidazole moiety at the periphery were synthesized. The synthesized ligands, complexes, and polymers were purified and characterized to study the structure of the molecule. These synthesized complexes were used for photodynamic therapy application as the diamagnetic Zn and Al have the ability to produce and stabilize singlet oxygen species. The synthesized N4 molecules of aluminum iminomethoxy phenyl phthalocyanine and aluminum ethyl phenyl benzimidazolephthalocyanine showed better activity against MCF-7 cells. These results suggest that this assay may be used as an early biomarker of clinical response.https://www.frontiersin.org/articles/10.3389/fchem.2021.647331/fullphthalocyaninephotodynamic therapysinglet oxygenquantum yieldinfrared spectra |
| spellingShingle | Keshavananda Prabhu C. P. Manjunatha Nemakal Muthumuni Managa Tebello Nyokong Lokesh Koodlur Sannegowda Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application Frontiers in Chemistry phthalocyanine photodynamic therapy singlet oxygen quantum yield infrared spectra |
| title | Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application |
| title_full | Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application |
| title_fullStr | Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application |
| title_full_unstemmed | Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application |
| title_short | Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application |
| title_sort | symmetrically substituted zn and al phthalocyanines and polymers for photodynamic therapy application |
| topic | phthalocyanine photodynamic therapy singlet oxygen quantum yield infrared spectra |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2021.647331/full |
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