Hybrid Drug Delivery Patches Based on Spherical Cellulose Nanocrystals and Colloid Titania—Synthesis and Antibacterial Properties
Spherical cellulose nanocrystal-based hybrids grafted with titania nanoparticles were successfully produced for topical drug delivery. The conventional analytical filter paper was used as a precursor material for cellulose nanocrystals (CNC) production. Cellulose nanocrystals were extracted via a si...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-04-01
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| Series: | Nanomaterials |
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| Online Access: | http://www.mdpi.com/2079-4991/8/4/228 |
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| author | Olga L. Evdokimova Fredric G. Svensson Alexander V. Agafonov Sebastian Håkansson Gulaim A. Seisenbaeva Vadim G. Kessler |
| author_facet | Olga L. Evdokimova Fredric G. Svensson Alexander V. Agafonov Sebastian Håkansson Gulaim A. Seisenbaeva Vadim G. Kessler |
| author_sort | Olga L. Evdokimova |
| collection | DOAJ |
| description | Spherical cellulose nanocrystal-based hybrids grafted with titania nanoparticles were successfully produced for topical drug delivery. The conventional analytical filter paper was used as a precursor material for cellulose nanocrystals (CNC) production. Cellulose nanocrystals were extracted via a simple and quick two-step process based on first the complexation with Cu(II) solution in aqueous ammonia followed by acid hydrolysis with diluted H2SO4. Triclosan was selected as a model drug for complexation with titania and further introduction into the nanocellulose based composite. Obtained materials were characterized by a broad variety of microscopic, spectroscopic, and thermal analysis methods. The drug release studies showed long-term release profiles of triclosan from the titania based nanocomposite that agreed with Higuchi model. The bacterial susceptibility tests demonstrated that released triclosan retained its antibacterial activity against Escherichia coli and Staphylococcus aureus. It was found that a small amount of titania significantly improved the antibacterial activity of obtained nanocomposites, even without immobilization of model drug. Thus, the developed hybrid patches are highly promising candidates for potential application as antibacterial agents. |
| first_indexed | 2024-12-10T19:21:27Z |
| format | Article |
| id | doaj.art-eb34ecd960d744c98c8966fb19948e45 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-10T19:21:27Z |
| publishDate | 2018-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-eb34ecd960d744c98c8966fb19948e452022-12-22T01:36:28ZengMDPI AGNanomaterials2079-49912018-04-018422810.3390/nano8040228nano8040228Hybrid Drug Delivery Patches Based on Spherical Cellulose Nanocrystals and Colloid Titania—Synthesis and Antibacterial PropertiesOlga L. Evdokimova0Fredric G. Svensson1Alexander V. Agafonov2Sebastian Håkansson3Gulaim A. Seisenbaeva4Vadim G. Kessler5G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, Akademicheskaya St.1, 153045 Ivanovo, RussiaDepartment of Molecular Sciences, BioCenter, Swedish University of Agricultural Science, 750 07 Uppsala, SwedenG.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, Akademicheskaya St.1, 153045 Ivanovo, RussiaDepartment of Molecular Sciences, BioCenter, Swedish University of Agricultural Science, 750 07 Uppsala, SwedenDepartment of Molecular Sciences, BioCenter, Swedish University of Agricultural Science, 750 07 Uppsala, SwedenDepartment of Molecular Sciences, BioCenter, Swedish University of Agricultural Science, 750 07 Uppsala, SwedenSpherical cellulose nanocrystal-based hybrids grafted with titania nanoparticles were successfully produced for topical drug delivery. The conventional analytical filter paper was used as a precursor material for cellulose nanocrystals (CNC) production. Cellulose nanocrystals were extracted via a simple and quick two-step process based on first the complexation with Cu(II) solution in aqueous ammonia followed by acid hydrolysis with diluted H2SO4. Triclosan was selected as a model drug for complexation with titania and further introduction into the nanocellulose based composite. Obtained materials were characterized by a broad variety of microscopic, spectroscopic, and thermal analysis methods. The drug release studies showed long-term release profiles of triclosan from the titania based nanocomposite that agreed with Higuchi model. The bacterial susceptibility tests demonstrated that released triclosan retained its antibacterial activity against Escherichia coli and Staphylococcus aureus. It was found that a small amount of titania significantly improved the antibacterial activity of obtained nanocomposites, even without immobilization of model drug. Thus, the developed hybrid patches are highly promising candidates for potential application as antibacterial agents.http://www.mdpi.com/2079-4991/8/4/228titaniacellulose nanocrystalsdrug deliverybioactivitytriclosan |
| spellingShingle | Olga L. Evdokimova Fredric G. Svensson Alexander V. Agafonov Sebastian Håkansson Gulaim A. Seisenbaeva Vadim G. Kessler Hybrid Drug Delivery Patches Based on Spherical Cellulose Nanocrystals and Colloid Titania—Synthesis and Antibacterial Properties Nanomaterials titania cellulose nanocrystals drug delivery bioactivity triclosan |
| title | Hybrid Drug Delivery Patches Based on Spherical Cellulose Nanocrystals and Colloid Titania—Synthesis and Antibacterial Properties |
| title_full | Hybrid Drug Delivery Patches Based on Spherical Cellulose Nanocrystals and Colloid Titania—Synthesis and Antibacterial Properties |
| title_fullStr | Hybrid Drug Delivery Patches Based on Spherical Cellulose Nanocrystals and Colloid Titania—Synthesis and Antibacterial Properties |
| title_full_unstemmed | Hybrid Drug Delivery Patches Based on Spherical Cellulose Nanocrystals and Colloid Titania—Synthesis and Antibacterial Properties |
| title_short | Hybrid Drug Delivery Patches Based on Spherical Cellulose Nanocrystals and Colloid Titania—Synthesis and Antibacterial Properties |
| title_sort | hybrid drug delivery patches based on spherical cellulose nanocrystals and colloid titania synthesis and antibacterial properties |
| topic | titania cellulose nanocrystals drug delivery bioactivity triclosan |
| url | http://www.mdpi.com/2079-4991/8/4/228 |
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