Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract
Here, Khan et al. show that enhanced Zika virus replication in the lower female reproductive tract of mice and macaques associates with low expression of RNA sensing pattern recognition receptors, while IFNAR signaling may be critical in preventing viral dissemination to distal tissues.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12371-7 |
| _version_ | 1818343591873871872 |
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| author | Shahzada Khan Irene Lew Frank Wu Linda Fritts Krystal A. Fontaine Sakshi Tomar Martin Trapecar Hesham M. Shehata Melanie Ott Christopher J. Miller Shomyseh Sanjabi |
| author_facet | Shahzada Khan Irene Lew Frank Wu Linda Fritts Krystal A. Fontaine Sakshi Tomar Martin Trapecar Hesham M. Shehata Melanie Ott Christopher J. Miller Shomyseh Sanjabi |
| author_sort | Shahzada Khan |
| collection | DOAJ |
| description | Here, Khan et al. show that enhanced Zika virus replication in the lower female reproductive tract of mice and macaques associates with low expression of RNA sensing pattern recognition receptors, while IFNAR signaling may be critical in preventing viral dissemination to distal tissues. |
| first_indexed | 2024-12-13T16:33:01Z |
| format | Article |
| id | doaj.art-eb3899d102fc43d5bbcf48369a070e1a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:33:01Z |
| publishDate | 2019-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-eb3899d102fc43d5bbcf48369a070e1a2022-12-21T23:38:28ZengNature PortfolioNature Communications2041-17232019-09-0110111110.1038/s41467-019-12371-7Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tractShahzada Khan0Irene Lew1Frank Wu2Linda Fritts3Krystal A. Fontaine4Sakshi Tomar5Martin Trapecar6Hesham M. Shehata7Melanie Ott8Christopher J. Miller9Shomyseh Sanjabi10Virology and Immunology, Gladstone InstitutesVirology and Immunology, Gladstone InstitutesVirology and Immunology, Gladstone InstitutesCenter for Comparative Medicine, University of California, DavisVirology and Immunology, Gladstone InstitutesVirology and Immunology, Gladstone InstitutesVirology and Immunology, Gladstone InstitutesVirology and Immunology, Gladstone InstitutesVirology and Immunology, Gladstone InstitutesCenter for Comparative Medicine, University of California, DavisVirology and Immunology, Gladstone InstitutesHere, Khan et al. show that enhanced Zika virus replication in the lower female reproductive tract of mice and macaques associates with low expression of RNA sensing pattern recognition receptors, while IFNAR signaling may be critical in preventing viral dissemination to distal tissues.https://doi.org/10.1038/s41467-019-12371-7 |
| spellingShingle | Shahzada Khan Irene Lew Frank Wu Linda Fritts Krystal A. Fontaine Sakshi Tomar Martin Trapecar Hesham M. Shehata Melanie Ott Christopher J. Miller Shomyseh Sanjabi Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract Nature Communications |
| title | Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract |
| title_full | Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract |
| title_fullStr | Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract |
| title_full_unstemmed | Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract |
| title_short | Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract |
| title_sort | low expression of rna sensors impacts zika virus infection in the lower female reproductive tract |
| url | https://doi.org/10.1038/s41467-019-12371-7 |
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