Inflammatory Cytokine Profile and Plasticity of Brain and Spinal Microglia in Response to ATP and Glutamate

Inflammatory Cytokine Profile and Plasticity of Brain and Spinal Microglia in Response to ATP and Glutamate

Microglia are the primary cells in the central nervous system that identify and respond to injury or damage. Such a perturbation in the nervous system induces the release of molecules including ATP and glutamate that act as damage-associated molecular patterns (DAMPs). DAMPs are detected by microgli...

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Bibliographic Details
Main Authors: Sam Joshva Baskar Jesudasan, Somnath J. Gupta, Matthew A. Churchward, Kathryn G. Todd, Ian R. Winship
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
microglia
adenosine tri phosphate
glutamate
inflammation
spinal cord
brain
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.634020/full

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