Novel donors of nitric oxide derived of S-nitrosocysteine possessing antioxidant activities
Novel S-nitrosothiols possessing a phenolic function were investigated as nitric oxide (NO) donors. A study of NO release from these derivatives was carried out by electron spin resonance (ESR). All compounds gave rise to a characteristic three-line ESR signal in the presence of the complex [Fe(II)(...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
1999-11-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100011 |
| _version_ | 1818444102619889664 |
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| author | C. Petit V. Bernardes-Genisson P. Hoffmann J.-P. Souchard S. Labidalle |
| author_facet | C. Petit V. Bernardes-Genisson P. Hoffmann J.-P. Souchard S. Labidalle |
| author_sort | C. Petit |
| collection | DOAJ |
| description | Novel S-nitrosothiols possessing a phenolic function were investigated as nitric oxide (NO) donors. A study of NO release from these derivatives was carried out by electron spin resonance (ESR). All compounds gave rise to a characteristic three-line ESR signal in the presence of the complex [Fe(II)(MGD)2], revealing the formation of the complex [Fe(II)(MGD)2(NO)]. Furthermore, tests based on cytochrome c reduction were performed in order to study the ability of each phenolic disulfide, the final organic decomposition product of S-nitrosothiols, to trap superoxide radical anion (O2-). This study revealed a high reactivity of 1b and 3b towards O2-. For these two compounds, the respective inhibitory concentration (IC) 50 values were 92 µM and 43 µM. |
| first_indexed | 2024-12-14T19:10:36Z |
| format | Article |
| id | doaj.art-eb3a148de90a4d8db84cc025132fcc7a |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-14T19:10:36Z |
| publishDate | 1999-11-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-eb3a148de90a4d8db84cc025132fcc7a2022-12-21T22:50:44ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X1999-11-0132111407141210.1590/S0100-879X1999001100011Novel donors of nitric oxide derived of S-nitrosocysteine possessing antioxidant activitiesC. PetitV. Bernardes-GenissonP. HoffmannJ.-P. SouchardS. LabidalleNovel S-nitrosothiols possessing a phenolic function were investigated as nitric oxide (NO) donors. A study of NO release from these derivatives was carried out by electron spin resonance (ESR). All compounds gave rise to a characteristic three-line ESR signal in the presence of the complex [Fe(II)(MGD)2], revealing the formation of the complex [Fe(II)(MGD)2(NO)]. Furthermore, tests based on cytochrome c reduction were performed in order to study the ability of each phenolic disulfide, the final organic decomposition product of S-nitrosothiols, to trap superoxide radical anion (O2-). This study revealed a high reactivity of 1b and 3b towards O2-. For these two compounds, the respective inhibitory concentration (IC) 50 values were 92 µM and 43 µM.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100011nitric oxideS-nitrosothiols (thionitrites)antioxidantperoxynitrite |
| spellingShingle | C. Petit V. Bernardes-Genisson P. Hoffmann J.-P. Souchard S. Labidalle Novel donors of nitric oxide derived of S-nitrosocysteine possessing antioxidant activities Brazilian Journal of Medical and Biological Research nitric oxide S-nitrosothiols (thionitrites) antioxidant peroxynitrite |
| title | Novel donors of nitric oxide derived of S-nitrosocysteine possessing antioxidant activities |
| title_full | Novel donors of nitric oxide derived of S-nitrosocysteine possessing antioxidant activities |
| title_fullStr | Novel donors of nitric oxide derived of S-nitrosocysteine possessing antioxidant activities |
| title_full_unstemmed | Novel donors of nitric oxide derived of S-nitrosocysteine possessing antioxidant activities |
| title_short | Novel donors of nitric oxide derived of S-nitrosocysteine possessing antioxidant activities |
| title_sort | novel donors of nitric oxide derived of s nitrosocysteine possessing antioxidant activities |
| topic | nitric oxide S-nitrosothiols (thionitrites) antioxidant peroxynitrite |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100011 |
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