Potassium 6-Oxo-7,13,16,22-tetraazatetracyclo[12.6.2.1<sup>8,12</sup>.0<sup>17,21</sup>]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate

Potassium 6-Oxo-7,13,16,22-tetraazatetracyclo[12.6.2.1<sup>8,12</sup>.0<sup>17,21</sup>]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate

Potassium 6-oxo-7,13,16,22-tetraazatetracyclo[12.6.2.1<sup>8,12</sup>.0<sup>17,21</sup>]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate was synthesized through a multi-step pathway, starting from commercially available 3-iodo-1,2-phenylenediamine. Structure c...

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Bibliographic Details
Main Authors: Camille Blouet, Stéphanie Letast, Thomas Robert, Stéphane Bach, Noël Pinaud, Nicolas Joubert, Marie-Claude Viaud-Massuard, Jean Guillon, Cédric Logé, Caroline Denevault-Sabourin
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Molbank
Subjects:
macrocycle
quinoxaline
Pim kinases
kinase inhibitor
Online Access:https://www.mdpi.com/1422-8599/2023/4/M1735
Description
Summary:Potassium 6-oxo-7,13,16,22-tetraazatetracyclo[12.6.2.1<sup>8,12</sup>.0<sup>17,21</sup>]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate was synthesized through a multi-step pathway, starting from commercially available 3-iodo-1,2-phenylenediamine. Structure characterization of this new substituted macrocyclic quinoxaline compound was achieved using <sup>1</sup>H NMR, <sup>13</sup>C NMR, and HRMS spectral analysis. This new macrocyclic derivative demonstrated submicromolar potency on both Pim-1 and Pim-2 isoforms, with an interesting selectivity profile against a selected panel of human kinases.
ISSN:1422-8599

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