Novel peptides derived from neuropeptide Y prevent chemotherapy-induced bone marrow damage by regulating hematopoietic stem cell microenvironment
Chemotherapy-induced bone marrow damage is accompanied by acute nerve injury in the bone marrow (BM), resulting in sensory and autonomic neuropathy. Cisplatin, a popular chemotherapy drugs, induces the impairment of hematopoietic stem cells (HSCs) and bone marrow regeneration, leading to chronic bon...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-09-01
|
| Series: | Animal Cells and Systems |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19768354.2018.1517826 |
| _version_ | 1828240021213151232 |
|---|---|
| author | Min Hee Park Bosung Baek Hee Kyung Jin Jae-sung Bae |
| author_facet | Min Hee Park Bosung Baek Hee Kyung Jin Jae-sung Bae |
| author_sort | Min Hee Park |
| collection | DOAJ |
| description | Chemotherapy-induced bone marrow damage is accompanied by acute nerve injury in the bone marrow (BM), resulting in sensory and autonomic neuropathy. Cisplatin, a popular chemotherapy drugs, induces the impairment of hematopoietic stem cells (HSCs) and bone marrow regeneration, leading to chronic bone marrow abnormalities. Previously, we reported the protective roles of neuropeptide Y (NPY) against cisplatin-induced bone marrow impairment. In this study, we identified novel peptides, generated from full-length NPY that rescued cisplatin-induced sensory neuropathy and HSC suppression by regulating cell survival in the BM microenvironment. One of these peptides, especially, showed a better protective property against these impairments compared to that seen in full-length NPY. Therefore, we suggest the NPY sequences most effective against the chemotherapy-induced bone marrow dysfunction that could be potentially useful as therapeutic agents for patients receiving chemotherapy. |
| first_indexed | 2024-04-12T21:34:02Z |
| format | Article |
| id | doaj.art-eb3d3f22ce0f4b6e9fda74f835a134a8 |
| institution | Directory Open Access Journal |
| issn | 1976-8354 2151-2485 |
| language | English |
| last_indexed | 2024-04-12T21:34:02Z |
| publishDate | 2018-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Animal Cells and Systems |
| spelling | doaj.art-eb3d3f22ce0f4b6e9fda74f835a134a82022-12-22T03:15:58ZengTaylor & Francis GroupAnimal Cells and Systems1976-83542151-24852018-09-0122528128810.1080/19768354.2018.15178261517826Novel peptides derived from neuropeptide Y prevent chemotherapy-induced bone marrow damage by regulating hematopoietic stem cell microenvironmentMin Hee Park0Bosung Baek1Hee Kyung Jin2Jae-sung Bae3Kyungpook National UniversityKyungpook National UniversityKyungpook National UniversityKyungpook National UniversityChemotherapy-induced bone marrow damage is accompanied by acute nerve injury in the bone marrow (BM), resulting in sensory and autonomic neuropathy. Cisplatin, a popular chemotherapy drugs, induces the impairment of hematopoietic stem cells (HSCs) and bone marrow regeneration, leading to chronic bone marrow abnormalities. Previously, we reported the protective roles of neuropeptide Y (NPY) against cisplatin-induced bone marrow impairment. In this study, we identified novel peptides, generated from full-length NPY that rescued cisplatin-induced sensory neuropathy and HSC suppression by regulating cell survival in the BM microenvironment. One of these peptides, especially, showed a better protective property against these impairments compared to that seen in full-length NPY. Therefore, we suggest the NPY sequences most effective against the chemotherapy-induced bone marrow dysfunction that could be potentially useful as therapeutic agents for patients receiving chemotherapy.http://dx.doi.org/10.1080/19768354.2018.1517826Bone marrow damagebone marrow microenvironment cellsChemotherapyhematopoietic stem cellneuropeptide Y-derived recombinant peptides |
| spellingShingle | Min Hee Park Bosung Baek Hee Kyung Jin Jae-sung Bae Novel peptides derived from neuropeptide Y prevent chemotherapy-induced bone marrow damage by regulating hematopoietic stem cell microenvironment Animal Cells and Systems Bone marrow damage bone marrow microenvironment cells Chemotherapy hematopoietic stem cell neuropeptide Y-derived recombinant peptides |
| title | Novel peptides derived from neuropeptide Y prevent chemotherapy-induced bone marrow damage by regulating hematopoietic stem cell microenvironment |
| title_full | Novel peptides derived from neuropeptide Y prevent chemotherapy-induced bone marrow damage by regulating hematopoietic stem cell microenvironment |
| title_fullStr | Novel peptides derived from neuropeptide Y prevent chemotherapy-induced bone marrow damage by regulating hematopoietic stem cell microenvironment |
| title_full_unstemmed | Novel peptides derived from neuropeptide Y prevent chemotherapy-induced bone marrow damage by regulating hematopoietic stem cell microenvironment |
| title_short | Novel peptides derived from neuropeptide Y prevent chemotherapy-induced bone marrow damage by regulating hematopoietic stem cell microenvironment |
| title_sort | novel peptides derived from neuropeptide y prevent chemotherapy induced bone marrow damage by regulating hematopoietic stem cell microenvironment |
| topic | Bone marrow damage bone marrow microenvironment cells Chemotherapy hematopoietic stem cell neuropeptide Y-derived recombinant peptides |
| url | http://dx.doi.org/10.1080/19768354.2018.1517826 |
| work_keys_str_mv | AT minheepark novelpeptidesderivedfromneuropeptideypreventchemotherapyinducedbonemarrowdamagebyregulatinghematopoieticstemcellmicroenvironment AT bosungbaek novelpeptidesderivedfromneuropeptideypreventchemotherapyinducedbonemarrowdamagebyregulatinghematopoieticstemcellmicroenvironment AT heekyungjin novelpeptidesderivedfromneuropeptideypreventchemotherapyinducedbonemarrowdamagebyregulatinghematopoieticstemcellmicroenvironment AT jaesungbae novelpeptidesderivedfromneuropeptideypreventchemotherapyinducedbonemarrowdamagebyregulatinghematopoieticstemcellmicroenvironment |