Francisella tularensis disrupts TLR2-MYD88-p38 signaling early during infection to delay apoptosis of macrophages and promote virulence in the host

Francisella tularensis disrupts TLR2-MYD88-p38 signaling early during infection to delay apoptosis of macrophages and promote virulence in the host

ABSTRACT Francisella tularensis is a zoonotic pathogen and the causative agent of tularemia. F. tularensis replicates to high levels within the cytosol of macrophages and other host cells while subverting the host response to infection. Critical to the success of F. tularensis is its ability to dela...

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Bibliographic Details
Main Authors: P. Todd Benziger, Erik J. Kopping, Patrick A. McLaughlin, David G. Thanassi
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
bacterial pathogenesis
Francisella tularensis
macrophages
apoptosis
Online Access:https://journals.asm.org/doi/10.1128/mbio.01136-23

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