Does sex hormone-binding globulin cause insulin resistance during pubertal growth?
Background: The directional influences between serum sex hormone-binding globulin (SHBG), adiposity and insulin resistance during pubertal growth remain unclear. The aim of this study was to investigate bidirectional associations between SHBG and insulin resistance (HOMA-IR) and adiposity from child...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2019-04-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/8/5/EC-19-0044.xml |
| _version_ | 1818127779948920832 |
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| author | Shenglong Le Leiting Xu Moritz Schumann Na Wu Timo Törmäkangas Markku Alén Sulin Cheng Petri Wiklund |
| author_facet | Shenglong Le Leiting Xu Moritz Schumann Na Wu Timo Törmäkangas Markku Alén Sulin Cheng Petri Wiklund |
| author_sort | Shenglong Le |
| collection | DOAJ |
| description | Background: The directional influences between serum sex hormone-binding globulin (SHBG), adiposity and insulin resistance during pubertal growth remain unclear. The aim of this study was to investigate bidirectional associations between SHBG and insulin resistance (HOMA-IR) and adiposity from childhood to early adulthood.
Methods: Participants were 396 healthy girls measured at baseline (age 11.2 years) and at 1, 2, 4 and 7.5 years. Serum concentrations of estradiol, testosterone and SHBG were determined by ELISA, glucose and insulin by enzymatic photometry, insulin-like growth factor 1 (IGF-1) by time-resolved fluoroimmunoassays, whole-body fat mass by dual-energy X-ray absorptiometry and HOMA-IR were determined by homeostatic model assessment. The associations were examined using cross-lagged path models.
Results: In a cross-lagged path model, SHBG predicted HOMA-IR before menarche β = −0.320 (95% CI: −0.552 to −0.089), P = 0.007, independent of adiposity and IGF-1. After menarche, no directional effect was found between SHBG and insulin resistance or adiposity.
Conclusions: Our results suggest that in early puberty, decline in SHBG predicts development of insulin resistance, independent of adiposity. However, after menarche, no directional influences between SHBG, adiposity and insulin resistance were found, suggesting that observational associations between SHBG, adiposity and insulin resistance in pubertal children may be subject to confounding. Further research is needed to understand the underlying mechanisms of the associations between SHBG and cardiometabolic risk markers in peripubertal children. |
| first_indexed | 2024-12-11T07:22:47Z |
| format | Article |
| id | doaj.art-eb3e852a3743469bb7673e6420450ba5 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-11T07:22:47Z |
| publishDate | 2019-04-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-eb3e852a3743469bb7673e6420450ba52022-12-22T01:16:04ZengBioscientificaEndocrine Connections2049-36142049-36142019-04-0185510517https://doi.org/10.1530/EC-19-0044Does sex hormone-binding globulin cause insulin resistance during pubertal growth?Shenglong Le0Leiting Xu1Moritz Schumann2Na Wu3Timo Törmäkangas4Markku Alén5Sulin Cheng6Petri Wiklund7Exercise, Health and Technology Centre, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FinlandMedical School, Ningbo University, Ningbo, ChinaDepartment of Molecular and Cellular Sports Medicine, German Sport University Cologne, Cologne, Germany; The Key Laboratory of Systems Biomedicine, Ministry of Education, and Exercise Translational Medicine Center, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, ChinaExercise, Health and Technology Centre, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FinlandFaculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FinlandDepartment of Medical Rehabilitation, Oulu University Hospital, Oulu, FinlandExercise, Health and Technology Centre, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland; The Key Laboratory of Systems Biomedicine, Ministry of Education, and Exercise Translational Medicine Center, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, ChinaExercise, Health and Technology Centre, Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland; Department of Epidemiology and Biostatistics, Centre for Environment and Health, School of Public Health, Imperial College London, London, UK; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, FinlandBackground: The directional influences between serum sex hormone-binding globulin (SHBG), adiposity and insulin resistance during pubertal growth remain unclear. The aim of this study was to investigate bidirectional associations between SHBG and insulin resistance (HOMA-IR) and adiposity from childhood to early adulthood. Methods: Participants were 396 healthy girls measured at baseline (age 11.2 years) and at 1, 2, 4 and 7.5 years. Serum concentrations of estradiol, testosterone and SHBG were determined by ELISA, glucose and insulin by enzymatic photometry, insulin-like growth factor 1 (IGF-1) by time-resolved fluoroimmunoassays, whole-body fat mass by dual-energy X-ray absorptiometry and HOMA-IR were determined by homeostatic model assessment. The associations were examined using cross-lagged path models. Results: In a cross-lagged path model, SHBG predicted HOMA-IR before menarche β = −0.320 (95% CI: −0.552 to −0.089), P = 0.007, independent of adiposity and IGF-1. After menarche, no directional effect was found between SHBG and insulin resistance or adiposity. Conclusions: Our results suggest that in early puberty, decline in SHBG predicts development of insulin resistance, independent of adiposity. However, after menarche, no directional influences between SHBG, adiposity and insulin resistance were found, suggesting that observational associations between SHBG, adiposity and insulin resistance in pubertal children may be subject to confounding. Further research is needed to understand the underlying mechanisms of the associations between SHBG and cardiometabolic risk markers in peripubertal children.https://ec.bioscientifica.com/view/journals/ec/8/5/EC-19-0044.xmlsex hormone-binding globulininsulin resistanceadipositypubertymenarche |
| spellingShingle | Shenglong Le Leiting Xu Moritz Schumann Na Wu Timo Törmäkangas Markku Alén Sulin Cheng Petri Wiklund Does sex hormone-binding globulin cause insulin resistance during pubertal growth? Endocrine Connections sex hormone-binding globulin insulin resistance adiposity puberty menarche |
| title | Does sex hormone-binding globulin cause insulin resistance during pubertal growth? |
| title_full | Does sex hormone-binding globulin cause insulin resistance during pubertal growth? |
| title_fullStr | Does sex hormone-binding globulin cause insulin resistance during pubertal growth? |
| title_full_unstemmed | Does sex hormone-binding globulin cause insulin resistance during pubertal growth? |
| title_short | Does sex hormone-binding globulin cause insulin resistance during pubertal growth? |
| title_sort | does sex hormone binding globulin cause insulin resistance during pubertal growth |
| topic | sex hormone-binding globulin insulin resistance adiposity puberty menarche |
| url | https://ec.bioscientifica.com/view/journals/ec/8/5/EC-19-0044.xml |
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