Novel approach to mitigate radiation overexposure, α-, δ-Tocotrienol as radiation mitigator: A case report
Background: Usage of radioactive sources for various medical and industrial purposes is very popular globally. Despite various technical advances, radiation accidents do occur due to lack of adequate expertise and regulatory control. Vitamin E is known to have antioxidant properties capable of scave...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of Radiation and Cancer Research |
| Subjects: | |
| Online Access: | http://www.journalrcr.org/article.asp?issn=2588-9273;year=2020;volume=11;issue=1;spage=30;epage=33;aulast=Singh |
| Summary: | Background: Usage of radioactive sources for various medical and industrial purposes is very popular globally. Despite various technical advances, radiation accidents do occur due to lack of adequate expertise and regulatory control. Vitamin E is known to have antioxidant properties capable of scavenging free radicals, which has a critical role in the repair of radiation injuries. Tocopherols and tocotrienols belong to Vitamin E family and thus are used as radiation mitigators for the cases of accidental overexposure to radiation. Materials and Methods: In the present report, two such patients were treated using α-, δ-tocotrienol 400 mg twice daily for 6 months. Dose received by them was calculated and estimated to be 40 Gy. Results: Both the patients showed significant symptomatic improvement over 6 months.
Conclusion: As a result of the present case study, α-, δ-tocotrienol can be recommended as a cost-effective and well-tolerated treatment option. |
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| ISSN: | 2588-9273 2468-9203 |