Intrinsic neuronal excitability: implications for health and disease
The output of a single neuron depends on both synaptic connectivity and intrinsic membrane properties. Changes in both synaptic and intrinsic membrane properties have been observed during homeostatic processes (e.g., vestibular compensation) as well as in several central nervous system (CNS) disorde...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2011-08-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc.2011.026 |
| _version_ | 1831749932331040768 |
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| author | Wijesinghe Rajiv Camp Aaron J. |
| author_facet | Wijesinghe Rajiv Camp Aaron J. |
| author_sort | Wijesinghe Rajiv |
| collection | DOAJ |
| description | The output of a single neuron depends on both synaptic connectivity and intrinsic membrane properties. Changes in both synaptic and intrinsic membrane properties have been observed during homeostatic processes (e.g., vestibular compensation) as well as in several central nervous system (CNS) disorders. Although changes in synaptic properties have been extensively studied, particularly with regard to learning and memory, the contribution of intrinsic membrane properties to either physiological or pathological processes is much less clear. Recent research, however, has shown that alterations in the number, location or properties of voltage- and ligand-gated ion channels can underlie both normal and abnormal physiology, and that these changes arise via a diverse suite of molecular substrates. The literature reviewed here shows that changes in intrinsic neuronal excitability (presumably in concert with synaptic plasticity) can fundamentally modify the output of neurons, and that these modifications can subserve both homeostatic mechanisms and the pathogenesis of CNS disorders including epilepsy, migraine, and chronic pain. |
| first_indexed | 2024-12-21T22:17:56Z |
| format | Article |
| id | doaj.art-eb412f0479de46daa0ed24423e07cfbb |
| institution | Directory Open Access Journal |
| issn | 1868-5021 1868-503X |
| language | English |
| last_indexed | 2024-12-21T22:17:56Z |
| publishDate | 2011-08-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-eb412f0479de46daa0ed24423e07cfbb2022-12-21T18:48:24ZengDe GruyterBiomolecular Concepts1868-50211868-503X2011-08-012424725910.1515/bmc.2011.026Intrinsic neuronal excitability: implications for health and diseaseWijesinghe Rajiv0Camp Aaron J.1Discipline of Biomedical Science, School of Medical Sciences, Sydney Medical School, University of Sydney, L226, Cumberland Campus C42, East St. Lidcombe, NSW 1825, AustraliaDiscipline of Biomedical Science, School of Medical Sciences, Sydney Medical School, University of Sydney, L226, Cumberland Campus C42, East St. Lidcombe, NSW 1825, AustraliaThe output of a single neuron depends on both synaptic connectivity and intrinsic membrane properties. Changes in both synaptic and intrinsic membrane properties have been observed during homeostatic processes (e.g., vestibular compensation) as well as in several central nervous system (CNS) disorders. Although changes in synaptic properties have been extensively studied, particularly with regard to learning and memory, the contribution of intrinsic membrane properties to either physiological or pathological processes is much less clear. Recent research, however, has shown that alterations in the number, location or properties of voltage- and ligand-gated ion channels can underlie both normal and abnormal physiology, and that these changes arise via a diverse suite of molecular substrates. The literature reviewed here shows that changes in intrinsic neuronal excitability (presumably in concert with synaptic plasticity) can fundamentally modify the output of neurons, and that these modifications can subserve both homeostatic mechanisms and the pathogenesis of CNS disorders including epilepsy, migraine, and chronic pain.https://doi.org/10.1515/bmc.2011.026excitabilityhomeostaticintrinsic plasticitylong-term potentiationsynaptic plasticity |
| spellingShingle | Wijesinghe Rajiv Camp Aaron J. Intrinsic neuronal excitability: implications for health and disease Biomolecular Concepts excitability homeostatic intrinsic plasticity long-term potentiation synaptic plasticity |
| title | Intrinsic neuronal excitability: implications for health and disease |
| title_full | Intrinsic neuronal excitability: implications for health and disease |
| title_fullStr | Intrinsic neuronal excitability: implications for health and disease |
| title_full_unstemmed | Intrinsic neuronal excitability: implications for health and disease |
| title_short | Intrinsic neuronal excitability: implications for health and disease |
| title_sort | intrinsic neuronal excitability implications for health and disease |
| topic | excitability homeostatic intrinsic plasticity long-term potentiation synaptic plasticity |
| url | https://doi.org/10.1515/bmc.2011.026 |
| work_keys_str_mv | AT wijesingherajiv intrinsicneuronalexcitabilityimplicationsforhealthanddisease AT campaaronj intrinsicneuronalexcitabilityimplicationsforhealthanddisease |