Biominerallized Noble Metal‐Based RuO2 Nanozymes Against Myocardial Ischemic/Reperfusion Injury
Myocardial ischemia/reperfusion (IR) injury is the leading cause of morbidity and mortality among elderly worldwide. Oxidative burst, which involves the rapid release of reactive oxygen species (ROS), is the primary mechanism of IR‐mediated myocardial dysfunction and injury. Therefore, ROS eliminati...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-05-01
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| Series: | Advanced NanoBiomed Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/anbr.202200144 |
| _version_ | 1797831088955981824 |
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| author | Xi Li Xiangyi Ren Maodi Xie Mengli Zhu Yabing Zhang Tao Li Minfeng Huo Qian Li |
| author_facet | Xi Li Xiangyi Ren Maodi Xie Mengli Zhu Yabing Zhang Tao Li Minfeng Huo Qian Li |
| author_sort | Xi Li |
| collection | DOAJ |
| description | Myocardial ischemia/reperfusion (IR) injury is the leading cause of morbidity and mortality among elderly worldwide. Oxidative burst, which involves the rapid release of reactive oxygen species (ROS), is the primary mechanism of IR‐mediated myocardial dysfunction and injury. Therefore, ROS elimination shows great potential for modulating IR injury. Herein, BSA‐coated RuO2 nanoparticles (RuO2@BSA, RA NPs) as free radical scavengers are synthesized and their therapeutic effect against myocardial IR injury is explored. The in vitro antioxidant effect of RA NPs in cardiomyocytes is initially demonstrated. In ischemic myocardium, the RA NPs mimic multiple enzymes to remarkably reduce the infarcted area and restore cardiac function through a cascade of enzyme‐like reactions, including the transformation of superoxide anion into hydrogen peroxide (H2O2) and the subsequent decomposition of H2O2 to oxygen. The therapeutic mechanism of the RA NPs is based on ROS scavenging and the inhibition of apoptosis. These findings demonstrate the high clinical potential of RA NPs in IR injury treatment. |
| first_indexed | 2024-04-09T13:46:27Z |
| format | Article |
| id | doaj.art-eb42da0fad6b4c15ba91e20f01466c5f |
| institution | Directory Open Access Journal |
| issn | 2699-9307 |
| language | English |
| last_indexed | 2024-04-09T13:46:27Z |
| publishDate | 2023-05-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced NanoBiomed Research |
| spelling | doaj.art-eb42da0fad6b4c15ba91e20f01466c5f2023-05-09T03:31:31ZengWiley-VCHAdvanced NanoBiomed Research2699-93072023-05-0135n/an/a10.1002/anbr.202200144Biominerallized Noble Metal‐Based RuO2 Nanozymes Against Myocardial Ischemic/Reperfusion InjuryXi Li0Xiangyi Ren1Maodi Xie2Mengli Zhu3Yabing Zhang4Tao Li5Minfeng Huo6Qian Li7Department of Anesthesiology West China Hospital of Sichuan University Chengdu 610041 P.R. ChinaCore Facilities of West China Hospital Sichuan University Chengdu 610041 P.R. ChinaDepartment of Anesthesiology West China Hospital of Sichuan University Chengdu 610041 P.R. ChinaCore Facilities of West China Hospital Sichuan University Chengdu 610041 P.R. ChinaDepartment of Anesthesiology West China Hospital of Sichuan University Chengdu 610041 P.R. ChinaDepartment of Anesthesiology West China Hospital of Sichuan University Chengdu 610041 P.R. ChinaShanghai Tenth People's Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine School of Medicine Tongji University Shanghai 200072 P.R. ChinaDepartment of Anesthesiology West China Hospital of Sichuan University Chengdu 610041 P.R. ChinaMyocardial ischemia/reperfusion (IR) injury is the leading cause of morbidity and mortality among elderly worldwide. Oxidative burst, which involves the rapid release of reactive oxygen species (ROS), is the primary mechanism of IR‐mediated myocardial dysfunction and injury. Therefore, ROS elimination shows great potential for modulating IR injury. Herein, BSA‐coated RuO2 nanoparticles (RuO2@BSA, RA NPs) as free radical scavengers are synthesized and their therapeutic effect against myocardial IR injury is explored. The in vitro antioxidant effect of RA NPs in cardiomyocytes is initially demonstrated. In ischemic myocardium, the RA NPs mimic multiple enzymes to remarkably reduce the infarcted area and restore cardiac function through a cascade of enzyme‐like reactions, including the transformation of superoxide anion into hydrogen peroxide (H2O2) and the subsequent decomposition of H2O2 to oxygen. The therapeutic mechanism of the RA NPs is based on ROS scavenging and the inhibition of apoptosis. These findings demonstrate the high clinical potential of RA NPs in IR injury treatment.https://doi.org/10.1002/anbr.202200144apoptosisfree radical scavengersmyocardial ischemia/reperfusion injuriesoxidative stressesRuO2 |
| spellingShingle | Xi Li Xiangyi Ren Maodi Xie Mengli Zhu Yabing Zhang Tao Li Minfeng Huo Qian Li Biominerallized Noble Metal‐Based RuO2 Nanozymes Against Myocardial Ischemic/Reperfusion Injury Advanced NanoBiomed Research apoptosis free radical scavengers myocardial ischemia/reperfusion injuries oxidative stresses RuO2 |
| title | Biominerallized Noble Metal‐Based RuO2 Nanozymes Against Myocardial Ischemic/Reperfusion Injury |
| title_full | Biominerallized Noble Metal‐Based RuO2 Nanozymes Against Myocardial Ischemic/Reperfusion Injury |
| title_fullStr | Biominerallized Noble Metal‐Based RuO2 Nanozymes Against Myocardial Ischemic/Reperfusion Injury |
| title_full_unstemmed | Biominerallized Noble Metal‐Based RuO2 Nanozymes Against Myocardial Ischemic/Reperfusion Injury |
| title_short | Biominerallized Noble Metal‐Based RuO2 Nanozymes Against Myocardial Ischemic/Reperfusion Injury |
| title_sort | biominerallized noble metal based ruo2 nanozymes against myocardial ischemic reperfusion injury |
| topic | apoptosis free radical scavengers myocardial ischemia/reperfusion injuries oxidative stresses RuO2 |
| url | https://doi.org/10.1002/anbr.202200144 |
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