Immunodominant surface epitopes power immune evasion in the African trypanosome
Summary: The African trypanosome survives the immune response of its mammalian host by antigenic variation of its major surface antigen (the variant surface glycoprotein or VSG). Here we describe the antibody repertoires elicited by different VSGs. We show that the repertoires are highly restricted...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723002735 |
| _version_ | 1827985731336798208 |
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| author | Anastasia Gkeka Francisco Aresta-Branco Gianna Triller Evi P. Vlachou Monique van Straaten Mirjana Lilic Paul Dominic B. Olinares Kathryn Perez Brian T. Chait Renata Blatnik Thomas Ruppert Joseph P. Verdi C. Erec Stebbins F. Nina Papavasiliou |
| author_facet | Anastasia Gkeka Francisco Aresta-Branco Gianna Triller Evi P. Vlachou Monique van Straaten Mirjana Lilic Paul Dominic B. Olinares Kathryn Perez Brian T. Chait Renata Blatnik Thomas Ruppert Joseph P. Verdi C. Erec Stebbins F. Nina Papavasiliou |
| author_sort | Anastasia Gkeka |
| collection | DOAJ |
| description | Summary: The African trypanosome survives the immune response of its mammalian host by antigenic variation of its major surface antigen (the variant surface glycoprotein or VSG). Here we describe the antibody repertoires elicited by different VSGs. We show that the repertoires are highly restricted and are directed predominantly to distinct epitopes on the surface of the VSGs. They are also highly discriminatory; minor alterations within these exposed epitopes confer antigenically distinct properties to these VSGs and elicit different repertoires. We propose that the patterned and repetitive nature of the VSG coat focuses host immunity to a restricted set of immunodominant epitopes per VSG, eliciting a highly stereotyped response, minimizing cross-reactivity between different VSGs and facilitating prolonged immune evasion through epitope variation. |
| first_indexed | 2024-04-09T23:19:06Z |
| format | Article |
| id | doaj.art-eb43510b214a4df1a0e7c607d76c984e |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-09T23:19:06Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-eb43510b214a4df1a0e7c607d76c984e2023-03-22T04:36:47ZengElsevierCell Reports2211-12472023-03-01423112262Immunodominant surface epitopes power immune evasion in the African trypanosomeAnastasia Gkeka0Francisco Aresta-Branco1Gianna Triller2Evi P. Vlachou3Monique van Straaten4Mirjana Lilic5Paul Dominic B. Olinares6Kathryn Perez7Brian T. Chait8Renata Blatnik9Thomas Ruppert10Joseph P. Verdi11C. Erec Stebbins12F. Nina Papavasiliou13Division of Immune Diversity, German Cancer Research Center, 69120 Heidelberg, Germany; Faculty of Biosciences, University of Heidelberg, 69120 Heidelberg, Germany; Panosome GmbH, 69123 Heidelberg, GermanyDivision of Immune Diversity, German Cancer Research Center, 69120 Heidelberg, Germany; Division of Structural Biology of Infection and Immunity, German Cancer Research Center, 69120 Heidelberg, GermanyDivision of Immune Diversity, German Cancer Research Center, 69120 Heidelberg, GermanyDivision of Immune Diversity, German Cancer Research Center, 69120 Heidelberg, GermanyDivision of Structural Biology of Infection and Immunity, German Cancer Research Center, 69120 Heidelberg, GermanyLaboratory of Structural Microbiology, the Rockefeller University, New York, NY 10065, USALaboratory of Mass Spectrometry and Gaseous Ion Chemistry, the Rockefeller University, New York, NY 10065, USAProtein Expression and Purification Core Facility, EMBL Heidelberg, 69117 Heidelberg, GermanyLaboratory of Mass Spectrometry and Gaseous Ion Chemistry, the Rockefeller University, New York, NY 10065, USACenter for Molecular Biology of Heidelberg University, DKFZ-ZMBH Alliance, 69120 Heidelberg, GermanyCenter for Molecular Biology of Heidelberg University, DKFZ-ZMBH Alliance, 69120 Heidelberg, GermanyDivision of Immune Diversity, German Cancer Research Center, 69120 Heidelberg, Germany; Panosome GmbH, 69123 Heidelberg, GermanyDivision of Structural Biology of Infection and Immunity, German Cancer Research Center, 69120 Heidelberg, Germany; Corresponding authorDivision of Immune Diversity, German Cancer Research Center, 69120 Heidelberg, Germany; Corresponding authorSummary: The African trypanosome survives the immune response of its mammalian host by antigenic variation of its major surface antigen (the variant surface glycoprotein or VSG). Here we describe the antibody repertoires elicited by different VSGs. We show that the repertoires are highly restricted and are directed predominantly to distinct epitopes on the surface of the VSGs. They are also highly discriminatory; minor alterations within these exposed epitopes confer antigenically distinct properties to these VSGs and elicit different repertoires. We propose that the patterned and repetitive nature of the VSG coat focuses host immunity to a restricted set of immunodominant epitopes per VSG, eliciting a highly stereotyped response, minimizing cross-reactivity between different VSGs and facilitating prolonged immune evasion through epitope variation.http://www.sciencedirect.com/science/article/pii/S2211124723002735CP: Immunology |
| spellingShingle | Anastasia Gkeka Francisco Aresta-Branco Gianna Triller Evi P. Vlachou Monique van Straaten Mirjana Lilic Paul Dominic B. Olinares Kathryn Perez Brian T. Chait Renata Blatnik Thomas Ruppert Joseph P. Verdi C. Erec Stebbins F. Nina Papavasiliou Immunodominant surface epitopes power immune evasion in the African trypanosome Cell Reports CP: Immunology |
| title | Immunodominant surface epitopes power immune evasion in the African trypanosome |
| title_full | Immunodominant surface epitopes power immune evasion in the African trypanosome |
| title_fullStr | Immunodominant surface epitopes power immune evasion in the African trypanosome |
| title_full_unstemmed | Immunodominant surface epitopes power immune evasion in the African trypanosome |
| title_short | Immunodominant surface epitopes power immune evasion in the African trypanosome |
| title_sort | immunodominant surface epitopes power immune evasion in the african trypanosome |
| topic | CP: Immunology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723002735 |
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