Analgesic activity of new complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde
The physiological role of pain helps to avoid or limit the tissue damage and therefore it provides the vital protective function. It has been previously studied, that complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde as well as their components represent the prac...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nicolaus Copernicus University in Toruń, Poland - University Sports Center
2019-02-01
|
| Series: | Pedagogy and Psychology of Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/czasopisma/index.php/PPS/article/view/20809 |
| _version_ | 1818658595766534144 |
|---|---|
| author | Elena Prokopchuk Alexandra Aleksandrova Iryna Kravchenko |
| author_facet | Elena Prokopchuk Alexandra Aleksandrova Iryna Kravchenko |
| author_sort | Elena Prokopchuk |
| collection | DOAJ |
| description | The physiological role of pain helps to avoid or limit the tissue damage and therefore it provides the vital protective function. It has been previously studied, that complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde as well as their components represent the practical interest by the manifestation of anti-inflammatory and antidepressive action. In this case the analgesic properties of the complexes themselves, as well as compounds belonging to their structure were of interest of our study. The experiments were performed on white mice. Several chemical (allyl isothiocyanate or AITC, capsaicin, formalin) and thermal effects have been chosen in this investigation for studying the analgesic activity and establishing the possible mechanisms of antinociceptive effect.
The tested compounds showed a mixed type of receptor interaction using models with different types of stimulation, which allows to make conclusions about their perspective as highly effective analgesics with a complex mechanism of action. |
| first_indexed | 2024-12-17T03:59:53Z |
| format | Article |
| id | doaj.art-eb43a2d5f49a4ef2bf8d4e7fed75e868 |
| institution | Directory Open Access Journal |
| issn | 2450-6605 2450-6605 |
| language | English |
| last_indexed | 2024-12-17T03:59:53Z |
| publishDate | 2019-02-01 |
| publisher | Nicolaus Copernicus University in Toruń, Poland - University Sports Center |
| record_format | Article |
| series | Pedagogy and Psychology of Sport |
| spelling | doaj.art-eb43a2d5f49a4ef2bf8d4e7fed75e8682022-12-21T22:04:33ZengNicolaus Copernicus University in Toruń, Poland - University Sports CenterPedagogy and Psychology of Sport2450-66052450-66052019-02-015215616410.12775/PPS.2015.05.02.00917177Analgesic activity of new complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehydeElena Prokopchuk0Alexandra Aleksandrova1Iryna Kravchenko2Odessa National Polytechnic University, Shevchenko Avenue 1, OdessaOdessa National Polytechnic University, Shevchenko Avenue 1, OdessaOdessa National Polytechnic University, Shevchenko Avenue 1, OdessaThe physiological role of pain helps to avoid or limit the tissue damage and therefore it provides the vital protective function. It has been previously studied, that complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde as well as their components represent the practical interest by the manifestation of anti-inflammatory and antidepressive action. In this case the analgesic properties of the complexes themselves, as well as compounds belonging to their structure were of interest of our study. The experiments were performed on white mice. Several chemical (allyl isothiocyanate or AITC, capsaicin, formalin) and thermal effects have been chosen in this investigation for studying the analgesic activity and establishing the possible mechanisms of antinociceptive effect. The tested compounds showed a mixed type of receptor interaction using models with different types of stimulation, which allows to make conclusions about their perspective as highly effective analgesics with a complex mechanism of action.https://apcz.umk.pl/czasopisma/index.php/PPS/article/view/20809anti-inflammatoryaitcstannous chloridesalicyloylhydrazonesbrombenzaldehydebenzaldehyde |
| spellingShingle | Elena Prokopchuk Alexandra Aleksandrova Iryna Kravchenko Analgesic activity of new complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde Pedagogy and Psychology of Sport anti-inflammatory aitc stannous chloride salicyloylhydrazones brombenzaldehyde benzaldehyde |
| title | Analgesic activity of new complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde |
| title_full | Analgesic activity of new complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde |
| title_fullStr | Analgesic activity of new complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde |
| title_full_unstemmed | Analgesic activity of new complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde |
| title_short | Analgesic activity of new complex compounds SnCl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde |
| title_sort | analgesic activity of new complex compounds sncl4 with salicyloylhydrazones of benzaldehyde and brombenzaldehyde |
| topic | anti-inflammatory aitc stannous chloride salicyloylhydrazones brombenzaldehyde benzaldehyde |
| url | https://apcz.umk.pl/czasopisma/index.php/PPS/article/view/20809 |
| work_keys_str_mv | AT elenaprokopchuk analgesicactivityofnewcomplexcompoundssncl4withsalicyloylhydrazonesofbenzaldehydeandbrombenzaldehyde AT alexandraaleksandrova analgesicactivityofnewcomplexcompoundssncl4withsalicyloylhydrazonesofbenzaldehydeandbrombenzaldehyde AT irynakravchenko analgesicactivityofnewcomplexcompoundssncl4withsalicyloylhydrazonesofbenzaldehydeandbrombenzaldehyde |