Understanding Immune Cells in Tertiary Lymphoid Organ Development: It’s All Starting to Come Together
Tertiary lymphoid organs (TLOs) are frequently observed in tissues affected by non-resolving inflammation as a result of infection, autoimmunity, cancer and allograft rejection. These highly ordered structures resemble the cellular composition of lymphoid follicles typically associated with the sple...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00401/full |
| _version_ | 1818112573650763776 |
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| author | Gareth Wyn Jones David G Hill Simon Arnett Jones |
| author_facet | Gareth Wyn Jones David G Hill Simon Arnett Jones |
| author_sort | Gareth Wyn Jones |
| collection | DOAJ |
| description | Tertiary lymphoid organs (TLOs) are frequently observed in tissues affected by non-resolving inflammation as a result of infection, autoimmunity, cancer and allograft rejection. These highly ordered structures resemble the cellular composition of lymphoid follicles typically associated with the spleen and lymph node compartments. Although TLOs within tissues show varying degrees of organisation, they frequently display evidence of segregated T and B cell zones, follicular dendritic cell networks, a supporting stromal reticulum and high endothelial venules. In this respect, they mimic the activities of germinal centres and contribute to the local control of adaptive immune responses. Studies in various disease settings have described how these structures contribute to either beneficial or deleterious outcomes. While the development and architectural organisation of TLOs within inflamed tissues requires homeostatic chemokines, lymphoid and inflammatory cytokines and adhesion molecules, our understanding of the cells responsible for triggering these events is still evolving. Over the past 10-15 years novel immune cell subsets have been discovered that have more recently been implicated in the control of TLO development and function. In this review we will discuss the contribution of these cell types and consider the potential to develop new therapeutic strategies that target TLOs. |
| first_indexed | 2024-12-11T03:21:05Z |
| format | Article |
| id | doaj.art-eb45dbcacd4d44c799f359a7a68abc45 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T03:21:05Z |
| publishDate | 2016-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-eb45dbcacd4d44c799f359a7a68abc452022-12-22T01:22:38ZengFrontiers Media S.A.Frontiers in Immunology1664-32242016-10-01710.3389/fimmu.2016.00401220463Understanding Immune Cells in Tertiary Lymphoid Organ Development: It’s All Starting to Come TogetherGareth Wyn Jones0David G Hill1Simon Arnett Jones2School of Medicine, Cardiff UniversitySchool of Medicine, Cardiff UniversitySchool of Medicine, Cardiff UniversityTertiary lymphoid organs (TLOs) are frequently observed in tissues affected by non-resolving inflammation as a result of infection, autoimmunity, cancer and allograft rejection. These highly ordered structures resemble the cellular composition of lymphoid follicles typically associated with the spleen and lymph node compartments. Although TLOs within tissues show varying degrees of organisation, they frequently display evidence of segregated T and B cell zones, follicular dendritic cell networks, a supporting stromal reticulum and high endothelial venules. In this respect, they mimic the activities of germinal centres and contribute to the local control of adaptive immune responses. Studies in various disease settings have described how these structures contribute to either beneficial or deleterious outcomes. While the development and architectural organisation of TLOs within inflamed tissues requires homeostatic chemokines, lymphoid and inflammatory cytokines and adhesion molecules, our understanding of the cells responsible for triggering these events is still evolving. Over the past 10-15 years novel immune cell subsets have been discovered that have more recently been implicated in the control of TLO development and function. In this review we will discuss the contribution of these cell types and consider the potential to develop new therapeutic strategies that target TLOs.http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00401/fullAutoimmunityInfectionCancerRheumatoid arthritislymphoid neogenesisTertiary lymphoid organs |
| spellingShingle | Gareth Wyn Jones David G Hill Simon Arnett Jones Understanding Immune Cells in Tertiary Lymphoid Organ Development: It’s All Starting to Come Together Frontiers in Immunology Autoimmunity Infection Cancer Rheumatoid arthritis lymphoid neogenesis Tertiary lymphoid organs |
| title | Understanding Immune Cells in Tertiary Lymphoid Organ Development: It’s All Starting to Come Together |
| title_full | Understanding Immune Cells in Tertiary Lymphoid Organ Development: It’s All Starting to Come Together |
| title_fullStr | Understanding Immune Cells in Tertiary Lymphoid Organ Development: It’s All Starting to Come Together |
| title_full_unstemmed | Understanding Immune Cells in Tertiary Lymphoid Organ Development: It’s All Starting to Come Together |
| title_short | Understanding Immune Cells in Tertiary Lymphoid Organ Development: It’s All Starting to Come Together |
| title_sort | understanding immune cells in tertiary lymphoid organ development it s all starting to come together |
| topic | Autoimmunity Infection Cancer Rheumatoid arthritis lymphoid neogenesis Tertiary lymphoid organs |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00401/full |
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