A case of pituitary gland abscess associated with granulomatous hypophysitis
Abstract Background Granulomatous hypophysitis is a rare disease that presents with chronic inflammation of the pituitary gland. In this study, we reported a case of granulomatous hypophysitis associated with a pituitary abscess. Case presentation A 39-year-old woman presented with a 2-year history...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-023-03060-6 |
| _version_ | 1797952519841775616 |
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| author | Mohammad Mahdi Rabiei Kaveh Ebrahimzadeh Zahra Davoudi Farahnaz Bidari Zerehpoosh Farid Javandoust Gharehbagh Roghayeh Sedaghati Legha Lotfollahi Fatemeh Kalhor Ilad Alavi Darazam |
| author_facet | Mohammad Mahdi Rabiei Kaveh Ebrahimzadeh Zahra Davoudi Farahnaz Bidari Zerehpoosh Farid Javandoust Gharehbagh Roghayeh Sedaghati Legha Lotfollahi Fatemeh Kalhor Ilad Alavi Darazam |
| author_sort | Mohammad Mahdi Rabiei |
| collection | DOAJ |
| description | Abstract Background Granulomatous hypophysitis is a rare disease that presents with chronic inflammation of the pituitary gland. In this study, we reported a case of granulomatous hypophysitis associated with a pituitary abscess. Case presentation A 39-year-old woman presented with a 2-year history of infertility. For the past six months, she has suffered from amenorrhea, decreased libido, headaches, and vertigo. She was referred to our hospital with a suspected diagnosis of nonfunctioning pituitary adenoma based on her presentation and brain MRI findings. She underwent trans-sphenoidal surgery (TSS). Direct observation during surgery revealed drainage of malodor pus and pituitary gland abscess. The histopathological evaluation also showed granulomatous hypophysitis and neutrophilic microabscess formation. The patient was initially treated with high doses of ceftriaxone (2 g twice daily) and metronidazole (500 mg (mg) four times per day). Also, the patient received cortisol replacement therapy after the operation. After obtaining the antibiogram and culture results, the treatment regimen was continued for 4 weeks postoperatively, followed by amoxicillin-clavulanate (500/125 mg three times daily) for a total duration of 12 weeks. Conclusion The patient recovered uneventfully and the postoperative MRI was normal without any remnant lesions. |
| first_indexed | 2024-04-10T22:47:39Z |
| format | Article |
| id | doaj.art-eb487d0b5bcd434fa527afecb954331d |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-10T22:47:39Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-eb487d0b5bcd434fa527afecb954331d2023-01-15T12:14:59ZengBMCBMC Neurology1471-23772023-01-012311610.1186/s12883-023-03060-6A case of pituitary gland abscess associated with granulomatous hypophysitisMohammad Mahdi Rabiei0Kaveh Ebrahimzadeh1Zahra Davoudi2Farahnaz Bidari Zerehpoosh3Farid Javandoust Gharehbagh4Roghayeh Sedaghati5Legha Lotfollahi6Fatemeh Kalhor7Ilad Alavi Darazam8Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical SciencesSkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical SciencesDepartment of Endocrinology, Skull Base Research Center of Loghman Hakim Hospital, Shahid Beheshti University of Medical SciencesDepartment of Pathology, Loghman Hakim Hospital, Shahid Beheshti University of Medical SciencesInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical SciencesInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical SciencesDepartment of Nephrology, Loghman Hakim Hospital, Shahid Beheshti University of Medical SciencesShahid Beheshti University of Medical SciencesInfectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical SciencesAbstract Background Granulomatous hypophysitis is a rare disease that presents with chronic inflammation of the pituitary gland. In this study, we reported a case of granulomatous hypophysitis associated with a pituitary abscess. Case presentation A 39-year-old woman presented with a 2-year history of infertility. For the past six months, she has suffered from amenorrhea, decreased libido, headaches, and vertigo. She was referred to our hospital with a suspected diagnosis of nonfunctioning pituitary adenoma based on her presentation and brain MRI findings. She underwent trans-sphenoidal surgery (TSS). Direct observation during surgery revealed drainage of malodor pus and pituitary gland abscess. The histopathological evaluation also showed granulomatous hypophysitis and neutrophilic microabscess formation. The patient was initially treated with high doses of ceftriaxone (2 g twice daily) and metronidazole (500 mg (mg) four times per day). Also, the patient received cortisol replacement therapy after the operation. After obtaining the antibiogram and culture results, the treatment regimen was continued for 4 weeks postoperatively, followed by amoxicillin-clavulanate (500/125 mg three times daily) for a total duration of 12 weeks. Conclusion The patient recovered uneventfully and the postoperative MRI was normal without any remnant lesions.https://doi.org/10.1186/s12883-023-03060-6Granulomatous hypophysitisAbscessPituitary glandStreptococcus viridansCase report |
| spellingShingle | Mohammad Mahdi Rabiei Kaveh Ebrahimzadeh Zahra Davoudi Farahnaz Bidari Zerehpoosh Farid Javandoust Gharehbagh Roghayeh Sedaghati Legha Lotfollahi Fatemeh Kalhor Ilad Alavi Darazam A case of pituitary gland abscess associated with granulomatous hypophysitis BMC Neurology Granulomatous hypophysitis Abscess Pituitary gland Streptococcus viridans Case report |
| title | A case of pituitary gland abscess associated with granulomatous hypophysitis |
| title_full | A case of pituitary gland abscess associated with granulomatous hypophysitis |
| title_fullStr | A case of pituitary gland abscess associated with granulomatous hypophysitis |
| title_full_unstemmed | A case of pituitary gland abscess associated with granulomatous hypophysitis |
| title_short | A case of pituitary gland abscess associated with granulomatous hypophysitis |
| title_sort | case of pituitary gland abscess associated with granulomatous hypophysitis |
| topic | Granulomatous hypophysitis Abscess Pituitary gland Streptococcus viridans Case report |
| url | https://doi.org/10.1186/s12883-023-03060-6 |
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