Association between white matter lesions and cerebral Aβ burden.
INTRODUCTION:White matter lesions (WMLs), detected as hyperintensities on T2-weighted MRI, represent small vessel disease in the brain and are considered a potential risk factor for memory and cognitive impairment in older adults. The purpose of this study was to evaluate the association between WML...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6152974?pdf=render |
| _version_ | 1818338406589005824 |
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| author | Hyon-Ah Yi Kyoung Sook Won Hyuk Won Chang Hae Won Kim |
| author_facet | Hyon-Ah Yi Kyoung Sook Won Hyuk Won Chang Hae Won Kim |
| author_sort | Hyon-Ah Yi |
| collection | DOAJ |
| description | INTRODUCTION:White matter lesions (WMLs), detected as hyperintensities on T2-weighted MRI, represent small vessel disease in the brain and are considered a potential risk factor for memory and cognitive impairment in older adults. The purpose of this study was to evaluate the association between WMLs and cerebral amyloid-β (Aβ) burden in patients with cognitive impairment. METHODS:A total of 83 patients with cognitive impairment, who underwent brain MRI and F-18 florbetaben PET, were included prospectively: 19 patients were cognitively unimpaired, 30 exhibited mild cognitive impairment (MCI), and 34 exhibited dementia. The Fazekas scale was used to quantify WMLs on T2-weighted brain MR images. Cerebral Aβ burden was quantitatively estimated using volume-of-interest analysis. Differences in cerebral Aβ burden were evaluated between low-WML (Fazekas scale ≤1) and high-WML (Fazekas scale ≥2) groups. The relationship between the Fazekas rating and cerebral Aβ burden was evaluated using linear regression analysis after adjusting for age and sex. RESULTS:In the overall cohort, the high-WML group exhibited significantly higher Aβ burden compared with the low-WML group (P = 0.011) and cerebral Aβ burden was positively correlated with Fazekas rating (β = 0.299, P = 0.006). In patients with MCI, the high-WML group exhibited significantly higher Aβ burden compared with the low-WML group (P = 0.019) and cerebral Aβ burden was positively correlated with Fazekas rating (β = 0.517, P = 0.003). CONCLUSION:The presence of WMLs was associated with cerebral Aβ burden in patients with MCI. Our findings suggest that small vessel disease in the brain is related to Alzheimer's disease pathology. |
| first_indexed | 2024-12-13T15:10:36Z |
| format | Article |
| id | doaj.art-eb48ad6319e3453db0d7d6113e7ae72c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T15:10:36Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-eb48ad6319e3453db0d7d6113e7ae72c2022-12-21T23:40:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01139e020431310.1371/journal.pone.0204313Association between white matter lesions and cerebral Aβ burden.Hyon-Ah YiKyoung Sook WonHyuk Won ChangHae Won KimINTRODUCTION:White matter lesions (WMLs), detected as hyperintensities on T2-weighted MRI, represent small vessel disease in the brain and are considered a potential risk factor for memory and cognitive impairment in older adults. The purpose of this study was to evaluate the association between WMLs and cerebral amyloid-β (Aβ) burden in patients with cognitive impairment. METHODS:A total of 83 patients with cognitive impairment, who underwent brain MRI and F-18 florbetaben PET, were included prospectively: 19 patients were cognitively unimpaired, 30 exhibited mild cognitive impairment (MCI), and 34 exhibited dementia. The Fazekas scale was used to quantify WMLs on T2-weighted brain MR images. Cerebral Aβ burden was quantitatively estimated using volume-of-interest analysis. Differences in cerebral Aβ burden were evaluated between low-WML (Fazekas scale ≤1) and high-WML (Fazekas scale ≥2) groups. The relationship between the Fazekas rating and cerebral Aβ burden was evaluated using linear regression analysis after adjusting for age and sex. RESULTS:In the overall cohort, the high-WML group exhibited significantly higher Aβ burden compared with the low-WML group (P = 0.011) and cerebral Aβ burden was positively correlated with Fazekas rating (β = 0.299, P = 0.006). In patients with MCI, the high-WML group exhibited significantly higher Aβ burden compared with the low-WML group (P = 0.019) and cerebral Aβ burden was positively correlated with Fazekas rating (β = 0.517, P = 0.003). CONCLUSION:The presence of WMLs was associated with cerebral Aβ burden in patients with MCI. Our findings suggest that small vessel disease in the brain is related to Alzheimer's disease pathology.http://europepmc.org/articles/PMC6152974?pdf=render |
| spellingShingle | Hyon-Ah Yi Kyoung Sook Won Hyuk Won Chang Hae Won Kim Association between white matter lesions and cerebral Aβ burden. PLoS ONE |
| title | Association between white matter lesions and cerebral Aβ burden. |
| title_full | Association between white matter lesions and cerebral Aβ burden. |
| title_fullStr | Association between white matter lesions and cerebral Aβ burden. |
| title_full_unstemmed | Association between white matter lesions and cerebral Aβ burden. |
| title_short | Association between white matter lesions and cerebral Aβ burden. |
| title_sort | association between white matter lesions and cerebral aβ burden |
| url | http://europepmc.org/articles/PMC6152974?pdf=render |
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